Entry Name Renin secretion - Rhinopithecus roxellana (golden snub-nosed monkey)
Description The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. Renin is synthesized, stored in, and released into circulation by the juxtaglomerular (JG) cells of the kidney. Secretion of renin from JG cells at the organ level is controlled by the four main mechanisms: the sympathetic nervous system, the local JG apparatus baroreflex, the macula densa mechanism, and several hormones acting locally within the JG apparatus. Renin secretion at the level of renal JG cells appears to be controlled mainly by classic second messengers, namely cAMP, cGMP, and free cytosolic calcium concentration. While cAMP generally stimulates renin release and the intracellular calcium concentration suppresses the exocytosis of renin, the effects of cGMP in the regulation of the renin system are more complex as it both may stimulate or inhibit renin release.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map Other DBs Organism Rhinopithecus roxellana (golden snub-nosed monkey) [GN:
rro ]
Gene 104654086 CLCA4; calcium-activated chloride channel regulator 4 isoform X1 [KO:K05030 ]
104654225 PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755 ] [EC:3.1.4.17 ]
104655475 ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262 ]
104655777 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
104655987 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630 ]
104659017 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
104659669 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
104661816 CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X5 [KO:K04853 ]
104661868 CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
104662238 KCNMA1; calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936 ]
104662590 CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183 ]
104663314 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
104663623 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
104663741 ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587 ]
104663797 GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632 ]
104663969 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
104664252 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
104666279 ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056 ]
104666593 PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3 [KO:K13755 ] [EC:3.1.4.17 ]
104667102 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630 ]
104668296 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
104669965 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
104670555 PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755 ] [EC:3.1.4.17 ]
104672388 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
104673307 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
104676931 PTGER4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261 ]
104679651 ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143 ]
104680220 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
104682225 CLCA1; calcium-activated chloride channel regulator 1 [KO:K05027 ]
104682226 CLCA2; calcium-activated chloride channel regulator 2 isoform X1 [KO:K05028 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Kurtz A
Title Renin release: sites, mechanisms, and control.
Journal Reference Authors Schweda F, Friis U, Wagner C, Skott O, Kurtz A
Title Renin release.
Journal Reference Authors Castrop H, Hocherl K, Kurtz A, Schweda F, Todorov V, Wagner C
Title Physiology of kidney renin.
Journal Reference Authors Friis UG, Madsen K, Stubbe J, Hansen PB, Svenningsen P, Bie P, Skott O, Jensen BL
Title Regulation of renin secretion by renal juxtaglomerular cells.
Journal Reference Authors Kim SM, Briggs JP, Schnermann J
Title Convergence of major physiological stimuli for renin release on the Gs-alpha/cyclic adenosine monophosphate signaling pathway.
Journal Reference Authors Kurtz A
Title Control of renin synthesis and secretion.
Journal Reference Authors Kurtz A, Wagner C
Title Cellular control of renin secretion.
Journal J Exp Biol 202:219-25 (1999)
Reference Authors Persson PB
Title Renin: origin, secretion and synthesis.
Journal Reference Authors Schweda F, Kurtz A
Title Cellular mechanism of renin release.
Journal Reference Authors Sparks MA, Crowley SD, Gurley SB, Mirotsou M, Coffman TM
Title Classical Renin-Angiotensin system in kidney physiology.
Journal Reference Authors Harrison-Bernard LM
Title The renal renin-angiotensin system.
Journal Reference Authors Schnermann J, Briggs JP
Title Synthesis and secretion of renin in mice with induced genetic mutations.
Journal Reference Authors Ryan MJ, Black TA, Millard SL, Gross KW, Hajduczok G
Title Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells.
Journal Reference Authors Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schutz G, Schweda F
Title Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors.
Journal Related KO pathway
