| Entry |
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| Name |
Renin secretion - Rhinopithecus roxellana (golden snub-nosed monkey)
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| Description |
The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. Renin is synthesized, stored in, and released into circulation by the juxtaglomerular (JG) cells of the kidney. Secretion of renin from JG cells at the organ level is controlled by the four main mechanisms: the sympathetic nervous system, the local JG apparatus baroreflex, the macula densa mechanism, and several hormones acting locally within the JG apparatus. Renin secretion at the level of renal JG cells appears to be controlled mainly by classic second messengers, namely cAMP, cGMP, and free cytosolic calcium concentration. While cAMP generally stimulates renin release and the intracellular calcium concentration suppresses the exocytosis of renin, the effects of cGMP in the regulation of the renin system are more complex as it both may stimulate or inhibit renin release.
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| Class |
Organismal Systems; Endocrine system
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| Pathway map |
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| Other DBs |
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| Organism |
Rhinopithecus roxellana (golden snub-nosed monkey) [GN: rro]
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| Gene |
| 104679651 | ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143] |
| 104655475 | ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262] |
| 104663741 | ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587] |
| 104676931 | PTGER4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261] |
| 104663797 | GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632] |
| 104680220 | CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870] |
| 104662238 | KCNMA1; calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936] |
| 104654225 | PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17] |
| 104666593 | PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3 [KO:K13755] [EC:3.1.4.17] |
| 104670555 | PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17] |
| 104655987 | GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630] |
| 104667102 | GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630] |
| 104673307 | GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630] |
| 104666279 | ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056] |
| 104682225 | CLCA1; calcium-activated chloride channel regulator 1 [KO:K05027] |
| 104682226 | CLCA2; calcium-activated chloride channel regulator 2 isoform X1 [KO:K05028] |
| 104654088 | calcium-activated chloride channel regulator 1-like isoform X1 [KO:K05030] |
| 104654086 | CLCA4; calcium-activated chloride channel regulator 4 isoform X1 [KO:K05030] |
| 104659017 | CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850] |
| 104672388 | CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851] |
| 104661816 | CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X5 [KO:K04853] |
| 104661868 | CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857] |
| 104663314 | GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634] |
| 104655777 | PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11] |
| 104668296 | PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11] |
| 104659669 | PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11] |
| 104664252 | ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958] |
| 104662590 | CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183] |
| 104663969 | PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16] |
| 104663623 | PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16] |
| 104669965 | PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16] |
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| Compound |
| C01245 | D-myo-Inositol 1,4,5-trisphosphate |
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| Reference |
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| Authors |
Kurtz A |
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| Title |
Renin release: sites, mechanisms, and control. |
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| Journal |
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| Reference |
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| Authors |
Schweda F, Friis U, Wagner C, Skott O, Kurtz A |
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| Title |
Renin release. |
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| Journal |
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| Reference |
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| Authors |
Castrop H, Hocherl K, Kurtz A, Schweda F, Todorov V, Wagner C |
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| Title |
Physiology of kidney renin. |
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| Journal |
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| Reference |
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| Authors |
Friis UG, Madsen K, Stubbe J, Hansen PB, Svenningsen P, Bie P, Skott O, Jensen BL |
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| Title |
Regulation of renin secretion by renal juxtaglomerular cells. |
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| Reference |
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| Authors |
Kim SM, Briggs JP, Schnermann J |
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| Title |
Convergence of major physiological stimuli for renin release on the Gs-alpha/cyclic adenosine monophosphate signaling pathway. |
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| Journal |
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| Reference |
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| Authors |
Kurtz A |
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| Title |
Control of renin synthesis and secretion. |
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| Journal |
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| Reference |
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| Authors |
Kurtz A, Wagner C |
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| Title |
Cellular control of renin secretion. |
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| Journal |
J Exp Biol 202:219-25 (1999) |
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| Reference |
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| Authors |
Persson PB |
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| Title |
Renin: origin, secretion and synthesis. |
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| Journal |
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| Reference |
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| Authors |
Schweda F, Kurtz A |
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| Title |
Cellular mechanism of renin release. |
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| Journal |
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| Reference |
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| Authors |
Sparks MA, Crowley SD, Gurley SB, Mirotsou M, Coffman TM |
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| Title |
Classical Renin-Angiotensin system in kidney physiology. |
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| Journal |
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| Reference |
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| Authors |
Harrison-Bernard LM |
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| Title |
The renal renin-angiotensin system. |
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| Journal |
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| Reference |
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| Authors |
Schnermann J, Briggs JP |
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| Title |
Synthesis and secretion of renin in mice with induced genetic mutations. |
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| Reference |
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| Authors |
Ryan MJ, Black TA, Millard SL, Gross KW, Hajduczok G |
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Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells. |
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| Reference |
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| Authors |
Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schutz G, Schweda F |
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| Title |
Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors. |
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Related
pathway |
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| KO pathway |
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| LinkDB |
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