KEGG   PATHWAY: rro04020
Entry
rro04020                    Pathway                                
Name
Calcium signaling pathway - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
rro04020  Calcium signaling pathway
rro04020

Other DBs
GO: 0019722
Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104653554  CALML6; calmodulin-like protein 6 isoform X2 [KO:K02183]
104653717  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
104653776  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
104653804  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
104653917  [KO:K06268]
104653928  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
104654172  PLN; cardiac phospholamban [KO:K05852]
104654225  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
104654292  P2RX3; P2X purinoceptor 3 [KO:K05217]
104654481  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
104654736  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
104654819  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
104655283  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
104655304  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
104655407  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
104655430  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
104655440  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
104655485  F2R; proteinase-activated receptor 1 [KO:K03914]
104655599  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
104655777  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
104656314  FGF9; fibroblast growth factor 9 [KO:K04358]
104656317  FGF10; fibroblast growth factor 10 [KO:K04358]
104656501  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
104656871  [KO:K02183]
104656917  FGF7; fibroblast growth factor 7 [KO:K04358]
104657433  GRM5; metabotropic glutamate receptor 5 isoform X2 [KO:K04604]
104657452  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
104657722  DRD5; D(1B) dopamine receptor [KO:K05840]
104658109  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
104658160  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
104658170  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
104658202  FGF20; fibroblast growth factor 20 [KO:K04358]
104658393  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
104658457  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
104658857  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
104658903  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
104658948  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104658982  FGF23; fibroblast growth factor 23 [KO:K22428]
104658983  FGF6; fibroblast growth factor 6 [KO:K04358]
104659017  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
104659193  ADRB1; beta-1 adrenergic receptor [KO:K04141]
104659649  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
104659669  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
104659812  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
104660025  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
104660101  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
104660209  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
104660230  EDNRB; endothelin receptor type B [KO:K04198]
104660404  CASQ1; calsequestrin-1 [KO:K23468]
104660489  SLN; sarcolipin [KO:K22642]
104661043  [KO:K04258]
104661051  [KO:K04345] [EC:2.7.11.11]
104661142  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
104661187  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
104661238  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
104661254  [KO:K05863]
104661322  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
104661391  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
104661547  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
104661558  ORAI3; protein orai-3 [KO:K16058]
104661599  NTRK3; NT-3 growth factor receptor isoform X3 [KO:K05101] [EC:2.7.10.1]
104661639  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
104661731  AVPR1B; vasopressin V1b receptor [KO:K04227]
104661758  FGF2; fibroblast growth factor 2 [KO:K18497]
104661816  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X5 [KO:K04853]
104661868  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
104661964  TACR2; substance-K receptor isoform X1 [KO:K04223]
104662002  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
104662055  [KO:K02183]
104662061  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
104662149  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
104662253  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
104662367  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
104662549  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
104662590  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
104662672  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
104662674  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
104662678  LTB4R2; leukotriene B4 receptor 2 isoform X2 [KO:K04297]
104662717  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
104662753  CYSLTR2; cysteinyl leukotriene receptor 2 isoform X1 [KO:K04323]
104663033  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
104663170  CALM2; calmodulin-2 [KO:K02183]
104663314  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
104663317  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
104663348  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
104663588  C2H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
104663623  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104663674  MRLN; myoregulin [KO:K22643]
104663703  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
104663797  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
104663799  [KO:K04632]
104663832  NTSR1; neurotensin receptor type 1 [KO:K04211]
104663951  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
104663969  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104664168  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
104664252  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
104664532  VEGFD; vascular endothelial growth factor D [KO:K05449]
104664696  [KO:K06856]
104664834  CALML5; calmodulin-like protein 5 [KO:K02183]
104664835  CALML3; calmodulin-like protein 3 [KO:K02183]
104664882  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
104664899  TACR3; neuromedin-K receptor [KO:K04224]
104664975  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
104665173  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
104665441  TBXA2R; thromboxane A2 receptor [KO:K04264]
104665455  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
104665456  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
104665760  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
104665907  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
104665941  CASQ2; calsequestrin-2 [KO:K23445]
104666018  CCKAR; cholecystokinin receptor type A [KO:K04194]
104666042  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
104666130  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2 [KO:K05860] [EC:3.1.4.11]
104666141  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
104666270  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
104666272  P2RX4; P2X purinoceptor 4 [KO:K05218]
104666279  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
104666549  FGF21; fibroblast growth factor 21 [KO:K22429]
104666560  SPHK2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
104666582  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
104666593  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3 [KO:K13755] [EC:3.1.4.17]
104666652  TPCN1; two pore calcium channel protein 1 isoform X3 [KO:K16896]
104666778  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
104666781  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
104666856  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
104666916  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
104667164  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
104667181  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X2 [KO:K23450]
104667185  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
104667301  TFEB; transcription factor EB [KO:K15590]
104667310  MST1; hepatocyte growth factor-like protein isoform X4 [KO:K23441]
104667362  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
104667476  OXTR; oxytocin receptor [KO:K04229]
104667499  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
104667722  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
104667797  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104668296  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
104668603  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
104668781  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104668823  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
104668890  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
104668941  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
104668945  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
104669070  NGF; beta-nerve growth factor [KO:K02582]
104669357  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
104669605  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
104669771  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
104669950  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
104669965  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104669984  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
104670122  FGF18; fibroblast growth factor 18 [KO:K04358]
104670245  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
104670408  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104670410  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
104670544  CALM1; calmodulin-1 [KO:K02183]
104670555  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
104670806  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
104670807  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
104671146  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
104671165  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
104671441  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
104671458  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
104671523  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
104671550  AGTR1; type-1 angiotensin II receptor [KO:K04166]
104671624  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
104671883  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
104672220  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
104672288  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
104672388  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
104672500  ADORA2A; adenosine receptor A2a [KO:K04266]
104672569  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
104672686  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
104673082  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
104673127  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
104673281  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
104673287  HRH1; histamine H1 receptor [KO:K04149]
104673384  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
104673406  CALM3; calmodulin-3 [KO:K02183]
104673694  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
104673801  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
104673881  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
104673903  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
104673947  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
104673950  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
104674083  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
104674211  [KO:K02183]
104674294  [KO:K06856]
104674327  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
104674586  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
104674686  FGF16; fibroblast growth factor 16 [KO:K04358]
104674813  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X3 [KO:K05853] [EC:7.2.2.10]
104674836  TACR1; substance-P receptor [KO:K04222]
104674848  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
104675082  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
104675331  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
104675393  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
104675428  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
104675533  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
104675683  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
104675709  PTAFR; platelet-activating factor receptor [KO:K04279]
104675805  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
104675847  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
104675874  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
104675886  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104675975  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
104675994  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
104676027  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
104676106  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
104676442  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
104676623  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
104677032  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
104677074  [KO:K06856]
104677136  FGF3; fibroblast growth factor 3 [KO:K04358]
104677137  FGF4; fibroblast growth factor 4 [KO:K04358]
104677138  FGF19; fibroblast growth factor 19 [KO:K22603]
104677227  P2RX1; P2X purinoceptor 1 [KO:K05215]
104677250  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
104677252  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
104677489  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104677502  MCOLN2; mucolipin-2 [KO:K04993]
104677503  MCOLN3; mucolipin-3 isoform X2 [KO:K04994]
104677657  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
104677781  AVPR1A; vasopressin V1a receptor [KO:K04226]
104678089  GRPR; gastrin-releasing peptide receptor [KO:K04169]
104678289  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
104678733  VEGFC; vascular endothelial growth factor C [KO:K05449]
104678828  TNNC2; troponin C, skeletal muscle [KO:K12042]
104678934  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
104679189  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
104679194  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
104679486  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
104679640  FGFR1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
104679651  ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
104679824  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
104679865  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
104679962  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
104680284  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
104680382  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
104680383  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
104680447  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
104680741  [KO:K02183]
104680758  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
104680760  ADRB2; beta-2 adrenergic receptor [KO:K04142]
104681199  ORAI2; protein orai-2 isoform X1 [KO:K16057]
104681274  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
104681303  [KO:K26468]
104681333  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
104681408  [KO:K10785]
104681410  [KO:K10785]
104681441  ADORA2B; adenosine receptor A2b [KO:K04267]
104681557  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
104681576  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
104681837  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104681927  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
104681930  DRD1; D(1A) dopamine receptor [KO:K04144]
104682143  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
104682421  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
104682558  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
104682582  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
104682633  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
104682771  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
115891968  [KO:K23449]
115892733  [KO:K04856]
115892739  [KO:K04856]
115894591  [KO:K05862]
115895711  [KO:K05862]
115899072  [KO:K04258]
115899258  [KO:K05863]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
rro04010  MAPK signaling pathway
rro04070  Phosphatidylinositol signaling system
rro04210  Apoptosis
rro04720  Long-term potentiation
rro04730  Long-term depression
KO pathway
ko04020   

DBGET integrated database retrieval system