KEGG   REACTION: R02736
Entry
R02736                      Reaction                               
Name
beta-D-glucose-6-phosphate:NADP+ 1-oxoreductase
Definition
beta-D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH + H+
Equation
C01172 + C00006 <=> C01236 + C00005 + C00080
Comment
irreversible
Reaction class
RC00001  C00005_C00006
RC00066  C01172_C01236
Enzyme
1.1.1.49        1.1.1.363
Pathway
rn00030  Pentose phosphate pathway
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00004  Pentose phosphate pathway (Pentose phosphate cycle)
M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P
M00008  Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.49
     R02736  beta-D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH + H+
    1.1.1.363
     R02736  beta-D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.49
   R00835  D-Glucose 6-phosphate
    R02736  beta-D-Glucose 6-phosphate
  1.1.1.363
   R00835  D-Glucose 6-phosphate
    R02736  beta-D-Glucose 6-phosphate
Orthology
K00036  glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
K13937  hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31]
Reference
1  [PMID:14275652]
  Authors
SALAS M, VINUELA E, SOLS A.
  Title
SPONTANEOUS AND ENZYMATICALLY CATALYZED ANOMERIZATION OF GLUCOSE 6-PHOSPHATE AND  ANOMERIC SPECIFICITY OF RELATED ENZYMES.
  Journal
J Biol Chem 240:561-8 (1965)
Reference
2  [PMID:11457850]
  Authors
Miclet E, Stoven V, Michels PA, Opperdoes FR, Lallemand JY, Duffieux F.
  Title
NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase.
  Journal
J Biol Chem 276:34840-6 (2001)
DOI:10.1074/jbc.M105174200
Reference
3  [PMID:9485426]
  Authors
Cosgrove MS, Naylor C, Paludan S, Adams MJ, Levy HR
  Title
On the mechanism of the reaction catalyzed by glucose 6-phosphate dehydrogenase.
  Journal
Biochemistry 37:2759-67 (1998)
DOI:10.1021/bi972069y
LinkDB

KEGG   RCLASS: RC00066
Entry
RC00066                     RClass                                 
Definition
C1y-C7x:*-*:C1y+O1a+O2x-C1y+O6a+O7x
Reactant pair
C00031_C00198    C00092_C01236    C00124_C02669
C00140_C22488    C00181_C02266    C00185_C01093
C00191_C20890    C00198_C00221    C00333_C20889
C00625_C03792    C01019_C18028    C01132_C22489
C01172_C01236    C01510_C02994    C01825_C21955
C02143_C16581    C02431_C02991    C09791_C09804
C20829_C21064    C21040_C22218    C22200_C22201
Related class
Reaction
R00300 R00305 R00835 R01096 R01429 R01430 R01442 R01443
R01520 R01521 R01522 R02365 R02651 R02736 R03586 R03942
R06620 R07147 R07148 R08544 R08926 R09550 R10411 R10520
R10841 R10842 R10907 R11036 R12156 R12483 R12484 R12502
R12973 R12976
Enzyme
1.1.1.47        1.1.1.48        1.1.1.49        1.1.1.113       
1.1.1.118       1.1.1.119       1.1.1.120       1.1.1.121       
1.1.1.122       1.1.1.173       1.1.1.175       1.1.1.179       
1.1.1.203       1.1.1.233       1.1.1.359       1.1.1.360       
1.1.1.363       1.1.1.388       1.1.1.390       1.1.1.419       
1.1.1.420       1.1.1.-         1.1.3.4         1.1.3.5         
1.1.3.29        1.1.5.2         1.1.5.9         1.1.98.2        
1.1.99.18       1.1.99.35
Pathway
rn00030  Pentose phosphate pathway
rn00040  Pentose and glucuronate interconversions
rn00051  Fructose and mannose metabolism
rn00052  Galactose metabolism
rn00053  Ascorbate and aldarate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
RModule
RM034  Sugar degradation to aldehyde and pyruvate
Orthology
K00034  glucose 1-dehydrogenase [EC:1.1.1.47]
K00036  glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
K00064  D-threo-aldose 1-dehydrogenase [EC:1.1.1.122]
K00078  dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP) [EC:1.3.1.20 1.1.1.179]
K00115  glucose 1-dehydrogenase (FAD, quinone) [EC:1.1.5.9]
K00117  quinoprotein glucose dehydrogenase [EC:1.1.5.2]
K13937  hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31]
K14273  D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) [EC:1.1.1.179]
K18124  glucose/galactose 1-dehydrogenase (NADP+) [EC:1.1.1.360]
K18125  aldose 1-dehydrogenase [NAD(P)+] [EC:1.1.1.359]
K18337  L-rhamnose 1-dehydrogenase [EC:1.1.1.378 1.1.1.377 1.1.1.173]
K18981  uronate dehydrogenase [EC:1.1.1.203]
K19243  NAD+ dependent glucose-6-phosphate dehydrogenase [EC:1.1.1.388]
K19813  glucose dehydrogenase [EC:1.1.5.9]
K21840  hexose oxidase [EC:1.1.3.5]
K22185  D-xylose 1-dehydrogenase [EC:1.1.1.175]
K23003  L-galactose dehydrogenase [EC:1.1.1.-]

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