KEGG   REACTION: R02736
Entry
R02736                      Reaction                               
Name
beta-D-glucose-6-phosphate:NADP+ 1-oxoreductase
Definition
beta-D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH + H+
Equation
Comment
irreversible
Reaction class
RC00001  C00005_C00006
RC00066  C01172_C01236
Enzyme
1.1.1.49        1.1.1.363
Pathway
rn00030  Pentose phosphate pathway
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00004  Pentose phosphate pathway (Pentose phosphate cycle)
M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P
M00008  Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate
Orthology
K00036  glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
K13937  hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31]
Reference
1  [PMID:14275652]
  Authors
SALAS M, VINUELA E, SOLS A.
  Title
SPONTANEOUS AND ENZYMATICALLY CATALYZED ANOMERIZATION OF GLUCOSE 6-PHOSPHATE AND  ANOMERIC SPECIFICITY OF RELATED ENZYMES.
  Journal
J Biol Chem 240:561-8 (1965)
Reference
2  [PMID:11457850]
  Authors
Miclet E, Stoven V, Michels PA, Opperdoes FR, Lallemand JY, Duffieux F.
  Title
NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase.
  Journal
J Biol Chem 276:34840-6 (2001)
DOI:10.1074/jbc.M105174200
Reference
3  [PMID:9485426]
  Authors
Cosgrove MS, Naylor C, Paludan S, Adams MJ, Levy HR
  Title
On the mechanism of the reaction catalyzed by glucose 6-phosphate dehydrogenase.
  Journal
Biochemistry 37:2759-67 (1998)
DOI:10.1021/bi972069y
LinkDB

KEGG   RCLASS: RC00066
Entry
RC00066                     RClass                                 
Definition
C1y-C7x:*-*:C1y+O1a+O2x-C1y+O6a+O7x
Reactant pair
Related class
Reaction
Enzyme
1.1.1.47        1.1.1.48        1.1.1.49        1.1.1.113       
1.1.1.118       1.1.1.119       1.1.1.120       1.1.1.121       
1.1.1.122       1.1.1.173       1.1.1.175       1.1.1.179       
1.1.1.203       1.1.1.233       1.1.1.359       1.1.1.360       
1.1.1.363       1.1.1.388       1.1.1.390       1.1.1.419       
1.1.1.420       1.1.1.-         1.1.3.4         1.1.3.5         
1.1.3.29        1.1.5.2         1.1.5.9         1.1.98.2        
1.1.99.18       1.1.99.35
Pathway
rn00030  Pentose phosphate pathway
rn00040  Pentose and glucuronate interconversions
rn00051  Fructose and mannose metabolism
rn00052  Galactose metabolism
rn00053  Ascorbate and aldarate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
RModule
RM034  Sugar degradation to aldehyde and pyruvate
Orthology
K00034  glucose 1-dehydrogenase [EC:1.1.1.47]
K00036  glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
K00064  D-threo-aldose 1-dehydrogenase [EC:1.1.1.122]
K00078  dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP) [EC:1.3.1.20 1.1.1.179]
K00115  glucose 1-dehydrogenase (FAD, quinone) [EC:1.1.5.9]
K00117  quinoprotein glucose dehydrogenase [EC:1.1.5.2]
K13937  hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31]
K14273  D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) [EC:1.1.1.179]
K18124  glucose/galactose 1-dehydrogenase (NADP+) [EC:1.1.1.360]
K18125  aldose 1-dehydrogenase [NAD(P)+] [EC:1.1.1.359]
K18333  L-fucose dehydrogenase
K18337  L-rhamnose 1-dehydrogenase [EC:1.1.1.378 1.1.1.377 1.1.1.173]
K18981  uronate dehydrogenase [EC:1.1.1.203]
K19243  NAD+ dependent glucose-6-phosphate dehydrogenase [EC:1.1.1.388]
K19813  glucose dehydrogenase [EC:1.1.5.9]
K21840  hexose oxidase [EC:1.1.3.5]
K22185  D-xylose 1-dehydrogenase [EC:1.1.1.175]
K23003  L-galactose dehydrogenase [EC:1.1.1.-]

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