KEGG   REACTION: R10633
Entry
R10633                      Reaction                               
Definition
NAD+ + Histone N6-acetyl-L-lysine + H2O <=> Nicotinamide + Histone-L-lysine + O-Acetyl-ADP-ribose + H+
Equation
C00003 + C01997 + C00001 <=> C00153 + C02415 + C20658 + C00080
Reaction class
RC00033  C00003_C00153
RC00096  C01997_C02415
Enzyme
2.3.1.286
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286
     R10633  NAD+ + Histone N6-acetyl-L-lysine + H2O <=> Nicotinamide + Histone-L-lysine + O-Acetyl-ADP-ribose + H+
IUBMB reaction hierarchy [BR:br08202]
 2. Transferase reactions
  2.3.1.286
   R10634  Protein N6-acetyl-L-lysine <=> Protein lysine
    R10633  Histone N6-acetyl-L-lysine <=> Histone-L-lysine
Orthology
K11121  NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
K11411  NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
K11412  NAD-dependent protein deacetylase sirtuin 2 [EC:2.3.1.286]
K11413  NAD-dependent protein deacetylase sirtuin 3 [EC:2.3.1.286]
K11414  NAD-dependent protein deacetylase/lipoamidase sirtuin 4 [EC:2.3.1.286 2.3.1.313]
K11415  NAD-dependent protein deacetylase sirtuin 5 [EC:2.3.1.286]
K11416  NAD-dependent protein deacetylase sirtuin 6 [EC:2.3.1.286]
K11417  NAD-dependent protein deacetylase sirtuin 7 [EC:2.3.1.286]
K12410  NAD-dependent protein deacetylase/lipoamidase [EC:2.3.1.286 2.3.1.313]
LinkDB

KEGG   REACTION: R10634
Entry
R10634                      Reaction                               
Definition
NAD+ + Protein N6-acetyl-L-lysine + H2O <=> Nicotinamide + Protein lysine + O-Acetyl-ADP-ribose + H+
Equation
C00003 + C20743 + C00001 <=> C00153 + C02188 + C20658 + C00080
Comment
Sirtuin
Reaction class
RC00033  C00003_C00153
RC00096  C02188_C20743
Enzyme
2.3.1.286
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286
     R10634  NAD+ + Protein N6-acetyl-L-lysine + H2O <=> Nicotinamide + Protein lysine + O-Acetyl-ADP-ribose + H+
IUBMB reaction hierarchy [BR:br08202]
 2. Transferase reactions
  2.3.1.286
   R10634  Protein N6-acetyl-L-lysine <=> Protein lysine
Orthology
K11121  NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
K11411  NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
K11412  NAD-dependent protein deacetylase sirtuin 2 [EC:2.3.1.286]
K11413  NAD-dependent protein deacetylase sirtuin 3 [EC:2.3.1.286]
K11414  NAD-dependent protein deacetylase/lipoamidase sirtuin 4 [EC:2.3.1.286 2.3.1.313]
K11415  NAD-dependent protein deacetylase sirtuin 5 [EC:2.3.1.286]
K11416  NAD-dependent protein deacetylase sirtuin 6 [EC:2.3.1.286]
K11417  NAD-dependent protein deacetylase sirtuin 7 [EC:2.3.1.286]
K12410  NAD-dependent protein deacetylase/lipoamidase [EC:2.3.1.286 2.3.1.313]
Other DBs
RHEA: 43639
LinkDB

KEGG   RCLASS: RC00033
Entry
RC00033                     RClass                                 
Definition
N5x-N5y:*-C1y:C8x+C8x-C8x+C8x
Reactant pair
C00003_C00153    C00006_C00153    C00153_C00455
C00153_C03150    C00253_C01185    C00253_C03003
C00253_C05841    C00253_C13051    C00396_C03169
C00396_C03536    C19574_C19606
Related class
Reaction
R00102 R00119 R00555 R01270 R01271 R01273 R01722 R01724
R02171 R02172 R02294 R02295 R02298 R03447 R04074 R04148
R04176 R09427 R10046 R10608 R10629 R10631 R10632 R10633
R10634 R10685 R12026
Enzyme
2.3.1.286       2.4.1.17        2.4.1.196       2.4.2.1         
2.4.2.2         2.4.2.12        2.4.2.21        2.4.2.30        
2.4.2.31        2.4.2.36        2.4.2.37        2.4.2.55        
2.4.2.59        2.4.2.60        2.4.99.20       3.2.2.3         
3.2.2.5         3.2.2.6         3.2.2.8         3.2.2.10        
3.2.2.14        3.5.1.-         6.3.4.21
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Orthology
K00699  glucuronosyltransferase [EC:2.4.1.17]
K00763  nicotinate phosphoribosyltransferase [EC:6.3.4.21]
K00768  nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21]
K01240  uridine nucleosidase [EC:3.2.2.3]
K01242  ADP-ribosyl cyclase 1 [EC:3.2.2.6 2.4.99.20]
K03146  cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60]
K03462  nicotinamide phosphoribosyltransferase [EC:2.4.2.12]
K03783  purine-nucleoside phosphorylase [EC:2.4.2.1]
K03784  purine-nucleoside phosphorylase [EC:2.4.2.1]
K11121  NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
K11411  NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
K11412  NAD-dependent protein deacetylase sirtuin 2 [EC:2.3.1.286]
K11413  NAD-dependent protein deacetylase sirtuin 3 [EC:2.3.1.286]
K11414  NAD-dependent protein deacetylase/lipoamidase sirtuin 4 [EC:2.3.1.286 2.3.1.313]
K11415  NAD-dependent protein deacetylase sirtuin 5 [EC:2.3.1.286]
K11416  NAD-dependent protein deacetylase sirtuin 6 [EC:2.3.1.286]
K11417  NAD-dependent protein deacetylase sirtuin 7 [EC:2.3.1.286]
K12410  NAD-dependent protein deacetylase/lipoamidase [EC:2.3.1.286 2.3.1.313]
K18152  ADP-ribosyl cyclase 2 [EC:3.2.2.6 2.4.99.20]
K18153  NAD+ glycohydrolase [EC:3.2.2.5]
K19980  ADP-ribosyltransferase 2 / NAD+ glycohydrolase [EC:2.4.2.31 3.2.2.5]
K22699  sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59]
K27536  NAD(+) hydrolase SARM1 [EC:3.2.2.6]

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