KEGG   PATHWAY: ajm04350
Entry
ajm04350                    Pathway                                
Name
TGF-beta signaling pathway - Artibeus jamaicensis (Jamaican fruit-eating bat)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
ajm04350  TGF-beta signaling pathway
ajm04350

Other DBs
GO: 0007179
Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119056456  CHRD; chordin isoform X1 [KO:K04657]
119062652  NOG; noggin [KO:K04658]
119045389  NBL1; neuroblastoma suppressor of tumorigenicity 1 isoform X1 [KO:K19558]
119040263  GREM1; gremlin-1 isoform X1 [KO:K23318]
119048510  GREM2; gremlin-2 isoform X1 [KO:K23318]
119048145  THBS1; thrombospondin-1 [KO:K16857]
119050955  DCN; decorin [KO:K04660]
119063419  FMOD; fibromodulin [KO:K08121]
119044444  left-right determination factor 2-like [KO:K04668]
119044447  left-right determination factor 2-like [KO:K04668]
119044469  left-right determination factor 1-like [KO:K04668]
119049167  FST; follistatin isoform X1 [KO:K04661]
119051190  BMP2; bone morphogenetic protein 2 [KO:K21283]
119057110  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
119046618  BMP6; bone morphogenetic protein 6 [KO:K16620]
119050047  INHBB; inhibin beta B chain [KO:K22687]
119048276  serotransferrin-like [KO:K14736]
119048279  inhibitor of carbonic anhydrase-like [KO:K14736]
119050880  serotransferrin-like [KO:K14736]
119054237  BMP5; bone morphogenetic protein 5 [KO:K04663]
119040640  BMP7; bone morphogenetic protein 7 [KO:K16621]
119052504  bone morphogenetic protein 8A-like [KO:K16622]
119063345  GDF5; growth/differentiation factor 5 [KO:K04664]
119038547  GDF6; growth/differentiation factor 6 [KO:K20012]
119054018  GDF7; growth/differentiation factor 7 [KO:K20013]
119043784  AMH; muellerian-inhibiting factor [KO:K04665]
119042309  IFNG; interferon gamma [KO:K04687]
119053704  TNF; tumor necrosis factor isoform X1 [KO:K03156]
119043315  THSD4; thrombospondin type-1 domain-containing protein 4 [KO:K23377]
119057608  FBN1; fibrillin-1 isoform X1 [KO:K06825]
119050337  LTBP1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
119058462  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
119045813  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
119049266  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
119058040  INHBA; inhibin beta A chain [KO:K04667]
119035679  INHBC; inhibin beta C chain [KO:K22688]
119035678  INHBE; inhibin beta E chain isoform X1 [KO:K22689]
119038090  NODAL; nodal homolog [KO:K04666]
119062395  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
119045406  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
119044109  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
119055277  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
119065590  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
119049408  HJV; hemojuvelin [KO:K23100]
119041313  NEO1; neogenin isoform X1 [KO:K06766]
119054914  HFE; hereditary hemochromatosis protein isoform X1 [KO:K26535]
119041595  TFR2; transferrin receptor protein 2 [KO:K23910]
119050872  TFRC; transferrin receptor protein 1 [KO:K06503]
119049127  RGMA; repulsive guidance molecule A [KO:K23096]
119055592  RGMB; RGM domain family member B [KO:K06847]
119043518  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
119045935  TGFBR1; LOW QUALITY PROTEIN: TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
119039725  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
119045649  EMP3; epithelial membrane protein 3 [KO:K26257]
119038946  LRRC32; transforming growth factor beta activator LRRC32 [KO:K26316]
119050904  NRROS; transforming growth factor beta activator LRRC33 [KO:K26317]
119043374  ACVR1B; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
119051549  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
119044110  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
119056218  IGSF1; LOW QUALITY PROTEIN: immunoglobulin superfamily member 1 [KO:K26168]
119063902  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
119061718  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
119044160  SMAD5; mothers against decapentaplegic homolog 5 [KO:K16790]
119044399  SMAD9; mothers against decapentaplegic homolog 9 isoform X1 [KO:K16791]
119063624  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
119057106  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
119063626  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
119057042  SMAD6; mothers against decapentaplegic homolog 6 [KO:K04677]
119063649  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
119036281  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
119062973  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
119058849  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
119059589  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
119060371  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
119051030  CUL1; cullin-1 [KO:K03347]
119037619  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
119040930  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119059157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119036699  RHOA; transforming protein RhoA [KO:K04513]
119059816  transforming protein RhoA-like [KO:K04513]
119047326  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
119058893  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
119038446  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
119042443  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
119061462  protein phosphatase PP2A regulatory subunit A-like [KO:K03456]
119049355  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
119036814  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
119053358  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
119041842  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
119062679  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
119037341  hepcidin [KO:K23106]
119047802  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
119054016  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
119042276  ID3; DNA-binding protein inhibitor ID-3 [KO:K17694]
119055416  ID4; DNA-binding protein inhibitor ID-4 [KO:K17695]
119063243  RBL1; retinoblastoma-like protein 1 [KO:K04681]
119043146  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
119061911  E2F4; transcription factor E2F4 isoform X1 [KO:K04682]
119034603  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
119060587  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
119056235  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
119043517  SP1; transcription factor Sp1 [KO:K04684]
119043447  SKIL; ski-like protein [KO:K18499]
119050547  SKI; ski oncogene [KO:K26503]
119055896  ski oncogene-like [KO:K26503]
119038476  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
119051413  transcriptional regulatory protein SIN3-like [KO:K11644]
119057513  transcriptional regulatory protein SIN3-like [KO:K11644]
119038662  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
119052290  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
119064403  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
119042376  TGIF1; homeobox protein TGIF1 isoform X1 [KO:K19383]
119063168  TGIF2; homeobox protein TGIF2 [KO:K19553]
119064823  MYC; myc proto-oncogene protein [KO:K04377]
119065838  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
119057471  PITX2; pituitary homeobox 2 isoform X1 [KO:K04686]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
ajm04010  MAPK signaling pathway
ajm04110  Cell cycle
ajm04120  Ubiquitin mediated proteolysis
ajm04210  Apoptosis
KO pathway
ko04350   
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