KEGG   PATHWAY: asao04350
Entry
asao04350                   Pathway                                
Name
TGF-beta signaling pathway - Anolis sagrei ordinatus (Brown anole)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
asao04350  TGF-beta signaling pathway
asao04350

Other DBs
GO: 0007179
Organism
Anolis sagrei ordinatus (Brown anole) [GN:asao]
Gene
132760882  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
132760954  BMP4; bone morphogenetic protein 4 [KO:K04662]
132761215  GREM2; gremlin-2 [KO:K23318]
132761274  LTBP1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
132761372  LEFTY1; left-right determination factor 1 isoform X1 [KO:K04668]
132761412  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
132762355  NEO1; neogenin isoform X1 [KO:K06766]
132762412  SMAD6; mothers against decapentaplegic homolog 6 [KO:K04677]
132762413  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
132762549  RGMA; repulsive guidance molecule A [KO:K23096]
132762608  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
132762721  FBN1; fibrillin-1 [KO:K06825]
132762768  THSD4; thrombospondin type-1 domain-containing protein 4 [KO:K23377]
132763369  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
132763407  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
132764247  TGFB3; LOW QUALITY PROTEIN: transforming growth factor beta-3 proprotein [KO:K13377]
132764403  [KO:K13376]
132764465  [KO:K23100]
132764768  NBL1; neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
132764949  SKI; ski oncogene [KO:K26503]
132765759  GREM1; gremlin-1 [KO:K23318]
132765864  THBS1; thrombospondin-1 [KO:K16857]
132766471  [KO:K04685]
132766766  [KO:K03156]
132766767  [KO:K03156]
132766768  [KO:K03156]
132766861  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
132766866  SMAD7; mothers against decapentaplegic homolog 7 [KO:K19631]
132766876  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
132766981  FST; follistatin isoform X1 [KO:K04661]
132767103  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
132767171  RGMB; repulsive guidance molecule B isoform X1 [KO:K06847]
132767620  [KO:K04513]
132767660  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
132767661  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
132767728  [KO:K22689]
132767783  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
132768146  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
132768261  NOG; noggin [KO:K04658]
132768303  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
132768882  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
132768883  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
132768905  SMAD5; mothers against decapentaplegic homolog 5 isoform X1 [KO:K16790]
132769106  RHOA; transforming protein RhoA [KO:K04513]
132769784  TFRC; LOW QUALITY PROTEIN: transferrin receptor protein 1 [KO:K06503]
132770175  NODAL; LOW QUALITY PROTEIN: nodal homolog [KO:K04666]
132770456  CHRD; chordin [KO:K04657]
132770512  SKIL; ski-like protein [KO:K18499]
132770736  NRROS; transforming growth factor beta activator LRRC33 [KO:K26317]
132770740  TF; serotransferrin [KO:K14736]
132771234  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
132771527  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
132772082  SMAD9; mothers against decapentaplegic homolog 9 isoform X1 [KO:K16791]
132772290  LRRC32; transforming growth factor beta activator LRRC32 [KO:K26316]
132772296  GDF7; growth/differentiation factor 7 [KO:K20013]
132772594  [KO:K23318]
132772806  [KO:K23318]
132772987  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
132773081  [KO:K17694]
132773106  BMP7; bone morphogenetic protein 7 isoform X1 [KO:K16621]
132773227  TGIF2; homeobox protein TGIF2 isoform X1 [KO:K19553]
132773257  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
132773258  [KO:K04681]
132773269  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
132773277  GDF5; growth/differentiation factor 5 [KO:K04664]
132773658  FMOD; fibromodulin [KO:K08121]
132773836  TMEM53; transmembrane protein 53 [KO:K28359]
132773922  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
132774305  INHBB; inhibin beta B chain [KO:K22687]
132774576  BMP6; bone morphogenetic protein 6 [KO:K16620]
132774627  ID4; DNA-binding protein inhibitor ID-4 [KO:K17695]
132774737  TGIF1; homeobox protein TGIF1 [KO:K19383]
132774754  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
132774781  [KO:K04388] [EC:2.7.11.30]
132774955  E2F5; transcription factor E2F5 [KO:K04682]
132775000  GDF6; growth/differentiation factor 6 [KO:K20012]
132775112  MYC; myc proto-oncogene protein [KO:K04377]
132775383  [KO:K04687]
132775577  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
132775977  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
132775978  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
132776061  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
132776067  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
132776105  DCN; decorin [KO:K04660]
132776189  LEMD3; inner nuclear membrane protein Man1 [KO:K19410]
132776822  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
132776914  PITX2; pituitary homeobox 2 isoform X1 [KO:K04686]
132776996  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
132777310  [KO:K28359]
132777498  TFR2; transferrin receptor protein 2 isoform X1 [KO:K23910]
132777818  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132777881  EMP3; epithelial membrane protein 3 isoform X1 [KO:K26257]
132778325  [KO:K23100]
132778483  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
132778519  CUL1; cullin-1 [KO:K03347]
132778540  INHBA; inhibin beta A chain [KO:K04667]
132778673  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
132778937  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
132778995  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
132779420  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
132780009  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
132780051  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
132780062  [KO:K04662]
132780254  HAMP; hepcidin [KO:K23106]
132780268  [KO:K21283]
132780269  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
132780394  [KO:K16622]
132780431  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
132780821  ID3; DNA-binding protein inhibitor ID-3 isoform X1 [KO:K17694]
132781138  AMH; muellerian-inhibiting factor [KO:K04665]
132781428  BMP2; bone morphogenetic protein 2 [KO:K21283]
132781464  [KO:K21283]
132781607  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132781756  [KO:K04658]
132782038  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
132782611  [KO:K23100]
132782700  [KO:K04686]
132782790  [KO:K04666]
132782958  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
132783019  E2F4; transcription factor E2F4 [KO:K04682]
132783046  BMP5; bone morphogenetic protein 5 [KO:K04663]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
asao04010  MAPK signaling pathway
asao04110  Cell cycle
asao04120  Ubiquitin mediated proteolysis
asao04210  Apoptosis
KO pathway
ko04350   

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