KEGG   PATHWAY: asao04010
Entry
asao04010                   Pathway                                
Name
MAPK signaling pathway - Anolis sagrei ordinatus (Brown anole)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
asao04010  MAPK signaling pathway
asao04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Anolis sagrei ordinatus (Brown anole) [GN:asao]
Gene
132760717  [KO:K03099]
132760722  FGF3; fibroblast growth factor 3 [KO:K04358]
132760802  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
132760994  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
132761043  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
132761109  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
132761123  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
132761186  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
132761223  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132761275  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
132761284  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
132761296  VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448]
132761397  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
132761412  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
132761483  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
132761509  SRF; serum response factor isoform X1 [KO:K04378]
132761544  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
132761545  SOS1; son of sevenless homolog 1 [KO:K03099]
132761597  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132761855  FGF4; fibroblast growth factor 4 [KO:K04358]
132761878  INS; insulin [KO:K04526]
132762384  FGF7; fibroblast growth factor 7 [KO:K04358]
132762408  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
132762417  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
132762445  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
132762556  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
132762994  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
132763093  [KO:K05096] [EC:2.7.10.1]
132763109  FGF16; fibroblast growth factor 16 [KO:K04358]
132763237  [KO:K04407] [EC:2.7.11.1]
132763302  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
132763326  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
132763461  CRK; adapter molecule crk [KO:K04438]
132763478  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
132763525  NF1; neurofibromin isoform X1 [KO:K08052]
132763641  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
132763864  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
132763887  HSPB1; heat shock protein beta-1 [KO:K04455]
132764117  [KO:K05462]
132764118  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
132764119  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
132764141  [KO:K03283]
132764247  TGFB3; LOW QUALITY PROTEIN: transforming growth factor beta-3 proprotein [KO:K13377]
132764274  RELA; transcription factor p65 [KO:K04735]
132764301  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
132764355  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
132764356  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
132764361  FOS; protein c-Fos [KO:K04379]
132764363  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
132764403  [KO:K13376]
132764404  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
132764415  VEGFB; vascular endothelial growth factor B [KO:K05448]
132764417  PGF; placenta growth factor isoform X1 [KO:K16859]
132764571  [KO:K03283]
132764609  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
132764663  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
132764781  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
132765730  RASGRP1; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 1 [KO:K04350]
132765850  [KO:K02308]
132765851  [KO:K02308]
132765949  [KO:K04453]
132766450  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
132766461  [KO:K16342] [EC:3.1.1.4]
132766485  [KO:K16342] [EC:3.1.1.4]
132766515  [KO:K16342] [EC:3.1.1.4]
132766526  [KO:K16342] [EC:3.1.1.4]
132766766  [KO:K03156]
132766767  [KO:K03156]
132766768  [KO:K03156]
132766934  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
132766969  FGF10; fibroblast growth factor 10 [KO:K04358]
132766999  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
132767087  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
132767109  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
132767131  RASA1; ras GTPase-activating protein 1 [KO:K04352]
132767138  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
132767187  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
132767277  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
132767314  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
132767449  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
132767586  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132767624  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
132767633  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
132767665  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
132767724  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
132767769  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
132767770  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
132767771  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
132767778  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
132767835  FLNA; filamin-A isoform X1 [KO:K04437]
132767845  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
132767858  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
132767870  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
132767942  [KO:K03158]
132768021  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
132768203  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
132768298  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
132768305  NR4A1; nuclear receptor subfamily 4immunitygroup A member 1 [KO:K04465]
132768344  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
132768395  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
132768541  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
132768609  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
132768620  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
132768665  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
132768694  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
132768719  [KO:K04345] [EC:2.7.11.11]
132768725  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
132768731  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
132768815  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
132768852  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
132768923  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
132768941  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
132768947  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
132768948  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
132768956  FGF19; fibroblast growth factor 19 [KO:K22603]
132769044  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
132769139  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
132769146  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
132769179  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132769229  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
132769268  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
132769269  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
132769275  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
132769661  [KO:K04729]
132769940  [KO:K04453]
132770298  [KO:K04439]
132770367  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
132770484  RRAS2; ras-related protein R-Ras2 [KO:K07830]
132770523  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
132770643  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
132770739  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
132770768  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
132770848  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
132770880  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
132770945  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132770994  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
132771014  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
132771115  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
132771118  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132771276  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
132771320  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
132771330  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
132771363  [KO:K16342] [EC:3.1.1.4]
132771374  [KO:K05094] [EC:2.7.10.1]
132771385  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
132771394  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
132771520  HRAS; GTPase HRas [KO:K02833]
132771568  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
132771569  [KO:K04386]
132771571  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
132771690  VEGFD; vascular endothelial growth factor D [KO:K05449]
132771723  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
132772117  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
132772119  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
132772143  FGF9; fibroblast growth factor 9 [KO:K04358]
132772192  PDGFD; LOW QUALITY PROTEIN: platelet-derived growth factor D [KO:K05450]
132772283  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
132772739  [KO:K04391]
132772740  [KO:K04391]
132772749  FASLG; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6 [KO:K04389]
132773006  ANGPT4; angiopoietin-4 [KO:K05467]
132773187  STK4; serine/threonine-protein kinase 4 [KO:K04411]
132773311  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
132773323  MAX; protein max isoform X1 [KO:K04453]
132773331  NGF; beta-nerve growth factor [KO:K02582]
132773340  NRAS; GTPase NRas [KO:K07828]
132773551  RAP1A; ras-related protein Rap-1A [KO:K04353]
132773604  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
132773624  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
132773738  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
132773739  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
132773753  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
132773787  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
132773822  ARTN; artemin isoform X1 [KO:K25415]
132773883  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
132773982  JUN; transcription factor Jun [KO:K04448]
132774030  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
132774031  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
132774078  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
132774169  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
132774263  MRAS; ras-related protein M-Ras [KO:K07831]
132774390  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
132774420  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
132774662  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
132774781  [KO:K04388] [EC:2.7.11.30]
132775015  STK3; serine/threonine-protein kinase 3 [KO:K04412]
132775053  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
132775112  MYC; myc proto-oncogene protein [KO:K04377]
132775415  FGF6; fibroblast growth factor 6 [KO:K04358]
132775416  FGF23; fibroblast growth factor 23 [KO:K22428]
132775450  FGF20; fibroblast growth factor 20 [KO:K04358]
132775597  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
132775705  KRAS; GTPase KRas isoform X1 [KO:K07827]
132775750  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
132775772  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
132775774  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
132775824  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
132775850  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
132775902  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
132775913  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
132775954  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
132775956  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
132775963  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
132775967  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
132776112  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
132776113  KITLG; kit ligand isoform X1 [KO:K05461]
132776159  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
132776179  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
132776222  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
132776257  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
132776292  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
132776293  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
132776430  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
132776439  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132776532  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
132776534  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
132776647  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
132776650  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
132776653  [KO:K05098] [EC:2.7.10.1]
132776702  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
132776719  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
132776766  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
132776776  PDGFC; platelet-derived growth factor C [KO:K05450]
132776870  FGF2; fibroblast growth factor 2 [KO:K18497]
132776917  EGF; pro-epidermal growth factor [KO:K04357]
132776959  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
132776964  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
132776969  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
132776995  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
132777024  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
132777087  [KO:K04453]
132777089  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
132777234  [KO:K05098] [EC:2.7.10.1]
132777273  FGF5; fibroblast growth factor 5 [KO:K04358]
132777305  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
132777453  ARRB2; beta-arrestin-2 [KO:K04439]
132777525  [KO:K04451]
132777527  [KO:K04451]
132777528  [KO:K04451]
132777726  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
132777801  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
132777807  [KO:K04468] [EC:2.7.11.24]
132777812  [KO:K04438]
132777818  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132777885  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
132777887  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
132777888  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
132777935  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
132777938  [KO:K07827]
132778046  [KO:K16342] [EC:3.1.1.4]
132778047  [KO:K16342] [EC:3.1.1.4]
132778048  [KO:K16342] [EC:3.1.1.4]
132778098  NTF4; neurotrophin-4 [KO:K12457]
132778112  RRAS; ras-related protein R-Ras isoform X1 [KO:K07830]
132778130  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
132778158  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
132778279  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
132778293  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
132778298  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
132778327  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
132778358  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
132778403  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
132778483  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
132778525  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
132778673  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
132778896  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
132778938  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
132779005  MYD88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729]
132779008  [KO:K04421] [EC:2.7.11.25]
132779046  [KO:K02583]
132779375  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
132779384  FGF21; fibroblast growth factor 21 [KO:K22429]
132779474  AREG; amphiregulin [KO:K09782]
132779475  EREG; proepiregulin [KO:K09784]
132779477  [KO:K07830]
132779609  [KO:K16342] [EC:3.1.1.4]
132780018  [KO:K04432] [EC:2.7.12.2]
132780030  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
132780051  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
132780057  RELB; transcription factor RelB [KO:K09253]
132780126  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
132780129  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132780170  [KO:K03283]
132780183  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
132780472  FGF22; fibroblast growth factor 22 [KO:K04358]
132780504  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
132780528  [KO:K05448]
132780558  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
132780674  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
132780714  STMN1; stathmin [KO:K04381]
132780744  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
132780789  [KO:K04457] [EC:3.1.3.16]
132780794  [KO:K04457] [EC:3.1.3.16]
132780958  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
132780992  JUND; transcription factor JunD [KO:K04449]
132781073  EFNA2; ephrin-A2 [KO:K05462]
132781102  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
132781292  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
132781453  [KO:K05466]
132781607  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132781682  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
132781741  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
132781753  NRTN; neurturin [KO:K25414]
132781815  FGF18; fibroblast growth factor 18 [KO:K04358]
132781860  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
132781880  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
132781912  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
132781913  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
132782023  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
132782099  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
132782165  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
132782299  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
132782482  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
132782524  TGFA; protransforming growth factor alpha [KO:K08774]
132782531  IL1B; interleukin-1 beta [KO:K04519]
132782619  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132782714  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
132782814  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
132783354  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
132783381  ANGPT2; angiopoietin-2 [KO:K05466]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
asao04070  Phosphatidylinositol signaling system
asao04110  Cell cycle
asao04115  p53 signaling pathway
asao04210  Apoptosis
asao04310  Wnt signaling pathway
KO pathway
ko04010   

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