KEGG   PATHWAY: bfo04141
Entry
bfo04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Branchiostoma floridae (Florida lancelet)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
bfo04141  Protein processing in endoplasmic reticulum
bfo04141

Other DBs
GO: 0030433 0034976
Organism
Branchiostoma floridae (Florida lancelet) [GN:bfo]
Gene
118415685  protein transport protein Sec61 subunit alpha [KO:K10956]
118405828  protein transport protein Sec61 subunit beta-like [KO:K09481]
118403933  protein transport protein Sec61 subunit gamma [KO:K07342]
118430510  translocation protein SEC62-like isoform X1 [KO:K12275]
118423233  translocation protein SEC63 homolog [KO:K09540]
118415886  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
118404202  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like isoform X1 [KO:K12667]
118418410  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1-like [KO:K12668]
118430635  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
118403582  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like isoform X1 [KO:K07151] [EC:2.4.99.18]
118405159  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A-like [KO:K07151] [EC:2.4.99.18]
118419964  tumor suppressor candidate 3-like isoform X1 [KO:K19478]
118410988  oligosaccharyltransferase complex subunit ostc-B [KO:K26501]
118413255  mannosyl-oligosaccharide glucosidase-like [KO:K01228] [EC:3.2.1.106]
118428988  ribosome-binding protein 1-like isoform X1 [KO:K14000]
118414805  nucleotide exchange factor SIL1-like [KO:K14001]
118412065  hypoxia up-regulated protein 1-like isoform X1 [KO:K09486]
118420822  endoplasmic reticulum chaperone BiP-like [KO:K09490] [EC:3.6.4.10]
118405555  dnaJ homolog subfamily B member 11-like [KO:K09517]
118424436  dnaJ homolog subfamily C member 1-like [KO:K09521]
118427271  dnaJ homolog subfamily C member 3-like isoform X1 [KO:K09523]
118405379  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
118415131  endoplasmin-like isoform X1 [KO:K09487]
118409589  endoplasmin-like isoform X1 [KO:K09487]
118430029  neutral alpha-glucosidase AB-like isoform X1 [KO:K05546] [EC:3.2.1.207]
118431763  glucosidase 2 subunit beta-like isoform X1 [KO:K08288]
118419134  calnexin-like isoform X1 [KO:K08054]
118409985  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
118431787  calreticulin-like [KO:K08057]
118422544  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like isoform X1 [KO:K01230] [EC:3.2.1.113]
118420800  LOW QUALITY PROTEIN: endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
118413364  LOW QUALITY PROTEIN: vesicular integral-membrane protein VIP36-like [KO:K10082]
118412437  protein ERGIC-53-like [KO:K10080]
118409487  prolactin regulatory element-binding protein-like isoform X1 [KO:K14003]
118411874  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
118411883  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
118416036  protein SEC13 homolog [KO:K14004]
118411599  protein transport protein Sec31A-like isoform X1 [KO:K14005]
118411514  protein transport protein Sec23A-like [KO:K14006]
118411884  protein transport protein Sec24A-like [KO:K14007]
118411387  protein transport protein Sec24C-like [KO:K14007]
118428044  UDP-glucose:glycoprotein glucosyltransferase 1-like [KO:K11718] [EC:2.4.1.-]
118415987  ER degradation-enhancing alpha-mannosidase-like protein 1 isoform X1 [KO:K10084]
118417440  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
118431300  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
118407841  protein disulfide-isomerase 2-like isoform X1 [KO:K09580] [EC:5.3.4.1]
118424588  protein disulfide-isomerase A4-like isoform X1 [KO:K09582] [EC:5.3.4.1]
118404486  protein disulfide-isomerase A6 homolog isoform X1 [KO:K09584] [EC:5.3.4.1]
118405380  dnaJ homolog subfamily C member 10-like [KO:K09584] [EC:5.3.4.1]
118417938  protein disulfide-isomerase like 2-1-like [KO:K09584] [EC:5.3.4.1]
118425646  endoplasmic reticulum resident protein 29-like [KO:K09586]
118403860  dnaJ homolog subfamily C member 10-like [KO:K13984] [EC:5.3.4.1]
118405127  thioredoxin domain-containing protein 5-like isoform X1 [KO:K13984] [EC:5.3.4.1]
118405140  thioredoxin domain-containing protein 5-like [KO:K13984] [EC:5.3.4.1]
118429165  ERO1-like protein beta [KO:K10976] [EC:1.8.4.-]
118403348  protein OS-9-like [KO:K10088]
118429141  endoplasmic reticulum lectin 1-like isoform X1 [KO:K14008]
118408870  translocon-associated protein subunit alpha-like [KO:K13249]
118410283  translocon-associated protein subunit beta-like isoform X1 [KO:K13250]
118431003  translocon-associated protein subunit gamma-like [KO:K13251]
118416476  translocon-associated protein subunit delta-like [KO:K04571]
118416479  B-cell receptor-associated protein 31-like isoform X1 [KO:K14009]
118404847  translocating chain-associated membrane protein 1-like isoform X1 [KO:K14010]
118417298  derlin-1-like [KO:K11519]
118426671  derlin-2-like [KO:K13989]
118403273  UBX domain-containing protein 4-like isoform X1 [KO:K24348]
118424140  UBX domain-containing protein 1-like [KO:K24348]
118419619  UBX domain-containing protein 6-like [KO:K14011]
118411246  UBX domain-containing protein 8-like isoform X1 [KO:K24351]
118406416  NSFL1 cofactor p47-like [KO:K14012]
118412212  small VCP/p97-interacting protein-like [KO:K14014]
118431801  transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
118429092  nuclear protein localization protein 4 homolog [KO:K14015]
118426131  ubiquitin recognition factor in ER-associated degradation protein 1-like [KO:K14016]
118403095  heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
118418471  heat shock cognate 71 kDa protein-like [KO:K03283]
118411940  dnaJ homolog subfamily A member 1-like isoform X1 [KO:K09502]
118417748  dnaJ homolog subfamily A member 2-like [KO:K09503]
118410932  dnaJ homolog subfamily B member 14-like isoform X1 [KO:K09518]
118428772  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
118426180  heat shock protein HSP 90-alpha-like [KO:K04079]
118418451  heat shock protein HSP 90-alpha-like [KO:K04079]
118429853  BAG family molecular chaperone regulator 1-like [KO:K09555]
118407963  BAG family molecular chaperone regulator 2-like [KO:K09556]
118414335  hsp70-binding protein 1-like [KO:K09562]
118425532  alpha-crystallin B chain-like [KO:K09542]
118426417  alpha-crystallin B chain-like [KO:K09542]
118432017  alpha-crystallin B chain-like [KO:K09542]
118432094  alpha-crystallin B chain-like [KO:K09542]
118432189  alpha-crystallin B chain-like [KO:K09542]
118432290  alpha-crystallin B chain-like isoform X1 [KO:K09542]
118416508  ubiquitin thioesterase OTU1-like [KO:K13719] [EC:3.1.2.-]
118431732  phospholipase A-2-activating protein-like [KO:K14018]
118431500  UV excision repair protein RAD23 homolog A-like [KO:K10839]
118410643  ubiquilin-1-like isoform X1 [KO:K04523]
118406119  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase-like [KO:K01456] [EC:3.5.1.52]
118409770  ataxin-3-like isoform X1 [KO:K11863] [EC:3.4.22.-]
118430961  ubiquitin conjugation factor E4 B-like [KO:K10597] [EC:2.3.2.27]
118409008  eukaryotic translation initiation factor 2-alpha kinase 3-like [KO:K08860] [EC:2.7.11.1]
118410129  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
118428974  activating transcription factor of chaperone-like [KO:K04374]
118420980  cyclic AMP-dependent transcription factor ATF-6 beta-like isoform X1 [KO:K09049]
118417031  membrane-bound transcription factor site-1 protease-like isoform X1 [KO:K08653] [EC:3.4.21.112]
118422803  membrane-bound transcription factor site-2 protease-like [KO:K07765] [EC:3.4.24.85]
118425763  LOW QUALITY PROTEIN: X-box-binding protein 1-like [KO:K09027]
118418587  LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
118407805  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
118407806  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
118407809  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
118409012  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
118409013  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
118409015  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
118409016  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
118409017  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
118409019  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
118409027  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
118420702  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
118411418  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
118407532  bcl-2 homologous antagonist/killer-like [KO:K14021]
118417554  E3 ubiquitin-protein ligase MARCHF6-like isoform X1 [KO:K10661] [EC:2.3.2.27]
118426002  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
118430417  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
118425458  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
118405368  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
118430996  E3 ubiquitin-protein ligase synoviolin-like [KO:K10601] [EC:2.3.2.27]
118426208  E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
118423851  selenoprotein S-like [KO:K14025]
118409839  protein sel-1 homolog 1-like isoform X1 [KO:K14026]
118418408  E3 ubiquitin-protein ligase AMFR-like isoform X1 [KO:K10636] [EC:2.3.2.36]
118429370  STIP1 homology and U box-containing protein 1-like [KO:K09561] [EC:2.3.2.27]
118429582  E3 ubiquitin-protein ligase CHIP-like isoform X1 [KO:K09561] [EC:2.3.2.27]
118408472  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
118411439  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
118421822  E3 ubiquitin-protein ligase parkin-like [KO:K04556] [EC:2.3.2.31]
118422731  E3 ubiquitin-protein ligase parkin-like [KO:K04556] [EC:2.3.2.31]
118419573  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
118403913  cullin-1 [KO:K03347]
118411438  S-phase kinase-associated protein 1 isoform X1 [KO:K03094]
118408504  F-box only protein 44-like [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
bfo00510  N-Glycan biosynthesis
bfo03050  Proteasome
bfo03060  Protein export
KO pathway
ko04141   
LinkDB

DBGET integrated database retrieval system