KEGG   PATHWAY: bfo04150
Entry
bfo04150                    Pathway                                
Name
mTOR signaling pathway - Branchiostoma floridae (Florida lancelet)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
bfo04150  mTOR signaling pathway
bfo04150

Organism
Branchiostoma floridae (Florida lancelet) [GN:bfo]
Gene
118406527  large neutral amino acids transporter small subunit 1-like [KO:K13780]
118417413  large neutral amino acids transporter small subunit 1-like [KO:K13780]
118418364  large neutral amino acids transporter small subunit 1-like isoform X1 [KO:K13780]
118418365  large neutral amino acids transporter small subunit 1-like [KO:K13780]
118431634  sodium-coupled neutral amino acid transporter 9-like [KO:K14995]
118413398  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
118412860  V-type proton ATPase subunit B isoform X1 [KO:K02147]
118404636  V-type proton ATPase subunit C 1-A-like isoform X1 [KO:K02148]
118420051  V-type proton ATPase subunit D-like [KO:K02149]
118406807  V-type proton ATPase subunit E-like [KO:K02150]
118403199  V-type proton ATPase subunit F-like [KO:K02151]
118421352  V-type proton ATPase subunit G-like [KO:K02152]
118404080  V-type proton ATPase subunit H-like [KO:K02144]
118418977  ragulator complex protein LAMTOR1-like [KO:K20397]
118428468  ragulator complex protein LAMTOR2-like [KO:K20398]
118411011  ragulator complex protein LAMTOR3-A-like isoform X1 [KO:K04370]
118428228  ragulator complex protein LAMTOR4-like [KO:K20399]
118416697  ragulator complex protein LAMTOR5 homolog [KO:K16344]
118428957  folliculin-like isoform X1 [KO:K09594]
118412405  folliculin-interacting protein 2-like isoform X1 [KO:K20401]
118427437  ras-related GTP-binding protein A [KO:K16185]
118404226  ras-related GTP-binding protein C-like isoform X1 [KO:K16186]
118427589  cytosolic arginine sensor for mTORC1 subunit 2-like [KO:K23081]
118424917  GATOR complex protein MIOS-A-like [KO:K20407]
118427239  nucleoporin SEH1-like [KO:K14299]
118429291  GATOR complex protein WDR24-like [KO:K20408]
118417274  GATOR complex protein WDR59-like isoform X1 [KO:K20409]
118416036  protein SEC13 homolog [KO:K14004]
118426624  GATOR complex protein DEPDC5-like isoform X1 [KO:K20404]
118417614  GATOR complex protein NPRL2-like [KO:K20405]
118428763  GATOR complex protein NPRL3-like isoform X1 [KO:K20406]
118432549  S-phase kinase-associated protein 2-like isoform X1 [KO:K03875]
118429076  regulatory-associated protein of mTOR-like [KO:K07204]
118412296  uncharacterized protein LOC118412296 [KO:K16184]
118430523  serine/threonine-protein kinase mTOR-like isoform X1 [KO:K07203] [EC:2.7.11.1]
118429203  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
118429712  target of rapamycin complex subunit lst8-like [KO:K08266]
118429344  telomere length regulation protein TEL2 homolog [KO:K11137]
118430514  TELO2-interacting protein 1 homolog [KO:K20403]
118425666  CAP-Gly domain-containing linker protein 1-like isoform X1 [KO:K10421]
118423877  growth factor receptor-bound protein 14-like isoform X1 [KO:K20064]
118421048  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
118411466  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
118427494  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
118425804  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
118403312  eukaryotic translation initiation factor 4B-like isoform X1 [KO:K03258]
118409387  40S ribosomal protein S6 [KO:K02991]
118403017  STE20-related kinase adapter protein alpha-like [KO:K08271]
118432534  serine/threonine-protein kinase stk11-like [KO:K07298] [EC:2.7.11.1]
118428262  calcium-binding protein 39-like isoform X1 [KO:K08272]
118431728  5'-AMP-activated protein kinase catalytic subunit alpha-2-like isoform X1 [KO:K07198] [EC:2.7.11.31]
118420790  hamartin-like [KO:K07206]
118428499  tuberin-like [KO:K07207]
118411713  TBC1 domain family member 7-like [KO:K20396]
118422947  GTP-binding protein Rheb-like [KO:K07208]
118405857  protein Wnt-1-like [KO:K03209]
118416575  protein Wnt-2b-A-like isoform X1 [KO:K00182]
118405399  LOW QUALITY PROTEIN: protein Wnt-3a-like [KO:K00312]
118430603  protein Wnt-4-like [KO:K00408]
118415326  protein Wnt-5b-like [KO:K00444]
118405738  protein Wnt-6-like isoform X1 [KO:K00445]
118408461  protein Wnt-7b-like [KO:K00572]
118416551  protein Wnt-7b-like isoform X1 [KO:K00572]
118411526  protein Wnt-8b-like isoform X1 [KO:K00714]
118405794  protein Wnt-9a-like isoform X1 [KO:K01064]
118405723  protein Wnt-10a-like [KO:K01357]
118427476  protein Wnt-11b-like [KO:K01384]
118415996  protein Wnt-16-like [KO:K01558]
118405674  frizzled-2-like [KO:K02432]
118430907  uncharacterized protein LOC118430907 [KO:K02432]
118423238  frizzled-4-like [KO:K02354]
118406142  frizzled-8-like [KO:K02375]
118422546  frizzled-9-like [KO:K02842]
118403062  uncharacterized protein LOC118403062 [KO:K03068]
118412841  low-density lipoprotein receptor-related protein 6-like [KO:K03068]
118409884  low-density lipoprotein receptor-related protein 5-like [KO:K03068]
118426980  low-density lipoprotein receptor-related protein 6-like [KO:K03068]
118427150  low-density lipoprotein receptor-related protein 4-like [KO:K03068]
118427485  hemicentin-2-like [KO:K03068]
118429980  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
118415612  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
118411310  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K07209] [EC:2.7.11.10]
118407319  bombyxin B-2 homolog [KO:K05459]
118410612  insulin-like peptide receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
118428890  growth factor receptor-bound protein 2-like [KO:K04364]
118424528  son of sevenless homolog 2-like isoform X1 [KO:K03099]
118413193  GTPase HRas-like [KO:K07827]
118430016  GTPase HRas [KO:K07828]
118416519  serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
118408739  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
118425949  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
118422481  ribosomal protein S6 kinase alpha-3-like isoform X1 [KO:K04373] [EC:2.7.11.1]
118404526  insulin receptor substrate 1-B-like isoform X1 [KO:K16172]
118432571  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
118430307  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
118430400  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
118411114  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118428892  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
118412491  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
118421622  target of rapamycin complex 2 subunit MAPKAP1-like isoform X1 [KO:K20410]
118431294  rapamycin-insensitive companion of mTOR-like [KO:K08267]
118417924  proline-rich protein 5-like isoform X1 [KO:K20411]
118411230  rho-related GTP-binding protein RhoA-C [KO:K04513]
118425455  ras-like GTP-binding protein Rho1 [KO:K04513]
118423227  ras-like GTP-binding protein RHO [KO:K04513]
118428737  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
118421866  regulator of G-protein signaling 3-like [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
bfo00561  Glycerolipid metabolism
bfo04140  Autophagy - animal
KO pathway
ko04150   
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