KEGG   PATHWAY: cery04350
Entry
cery04350                   Pathway                                
Name
TGF-beta signaling pathway - Chanodichthys erythropterus (predatory carp)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
cery04350  TGF-beta signaling pathway
cery04350

Other DBs
GO: 0007179
Organism
Chanodichthys erythropterus (predatory carp) [GN:cery]
Gene
137002073  bmp8a; bone morphogenetic protein 8A [KO:K16622]
137002390  tgfbr1a; TGF-beta receptor type-1a isoform X1 [KO:K04674] [EC:2.7.11.30]
137002546  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
137002588  acvr1l; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
137002671  [KO:K14736]
137002741  cul1a; cullin-1a isoform X1 [KO:K03347]
137002917  mycb; transcriptional regulator Myc-B [KO:K04377]
137003052  [KO:K13596] [EC:2.7.11.30]
137003201  tmem53; transmembrane protein 53 [KO:K28359]
137003251  tfr1a; transferrin receptor 1a isoform X1 [KO:K06503]
137003269  inhbab; inhibin subunit beta Ab [KO:K04667]
137003425  bambib; BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b [KO:K10162]
137003625  skila; ski-like protein [KO:K18499]
137003663  admp; anti-dorsalizing morphogenic protein [KO:K21283]
137003685  e2f5; transcription factor E2F5 [KO:K04682]
137003861  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
137003918  tfa; transferrin-a [KO:K14736]
137004117  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
137004570  chrd; chordin [KO:K04657]
137004972  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
137004988  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
137006109  ltbp1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
137006346  bmp2a; bone morphogenetic protein 2 [KO:K21283]
137006350  grem1b; gremlin-1 [KO:K23318]
137006351  bmp4; bone morphogenetic protein 4 [KO:K04662]
137006360  id3; DNA-binding protein inhibitor ID-3 [KO:K17694]
137006444  id2a; DNA-binding protein inhibitor ID-2a [KO:K17693]
137006632  grem2a; gremlin-2 [KO:K23318]
137006885  gdf7; growth/differentiation factor 6-A [KO:K20013]
137007060  lft2; lefty2 [KO:K04668]
137007076  [KO:K16857]
137007180  tgfb3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
137007532  [KO:K21283]
137007819  bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a [KO:K10162]
137008043  grem2b; gremlin-2b [KO:K23318]
137008051  nog3; noggin-3 [KO:K04658]
137008167  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
137008185  ndr2; nodal-related 2 [KO:K04666]
137008297  bmpr1ab; bone morphogenetic protein receptor, type IAb isoform X1 [KO:K04673] [EC:2.7.11.30]
137008856  tfr2; transferrin receptor protein 2 isoform X1 [KO:K23910]
137008905  bmp7b; bone morphogenetic protein 7b isoform X1 [KO:K16621]
137009089  acvr1ba; activin A receptor type 1Ba [KO:K13567] [EC:2.7.11.30]
137009104  emp3b; epithelial membrane protein 3b (MAM blood group) [KO:K26257]
137009132  nog1; noggin-1 [KO:K04658]
137009798  rhoac; rho-related GTP-binding protein RhoA-C isoform X1 [KO:K04513]
137010318  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
137010683  [KO:K19553]
137010778  rbl1; retinoblastoma-like protein 1 [KO:K04681]
137010811  acvr2ab; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
137010998  [KO:K22687]
137011183  bmpr2a; bone morphogenetic protein receptor type-2a isoform X1 [KO:K04671] [EC:2.7.11.30]
137011306  gdf5; growth/differentiation factor 5 [KO:K04664]
137011321  rhoca; ras homolog family member Ca [KO:K04513]
137011621  acvr1bb; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
137012525  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
137013043  smad7; mothers against decapentaplegic homolog 7 [KO:K19631]
137013047  skp1; S-phase kinase-associated protein 1 [KO:K03094]
137013180  ndr1; nodal-related 1 [KO:K04666]
137013218  nog5; noggin 5 [KO:K04658]
137013247  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
137013406  cul1b; cullin-1b isoform X1 [KO:K03347]
137013477  bmp6; bone morphogenetic protein 6 [KO:K16620]
137013555  myca; transcriptional regulator Myc-A [KO:K04377]
137013578  inhbaa; inhibin subunit beta Aa [KO:K04667]
137013598  nrros; transforming growth factor beta activator LRRC33 [KO:K26317]
137013784  tfr1b; transferrin receptor 1b isoform X1 [KO:K06503]
137013900  tgif1; homeobox protein TGIF1 [KO:K19383]
137014005  acvr2ba; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
137014087  skilb; SKI-like proto-oncogene b [KO:K18499]
137014092  nog2; noggin-2 [KO:K04658]
137014441  tgfbr1b; TGF-beta receptor type-1b isoform X1 [KO:K04674] [EC:2.7.11.30]
137014517  neo1b; neogenin isoform X1 [KO:K06766]
137014710  sin3aa; SIN3 transcription regulator family member Aa [KO:K11644]
137014741  e2f4; transcription factor E2F4 [KO:K04682]
137015152  pitx2; pituitary homeobox 2 isoform X1 [KO:K04686]
137017252  [KO:K04498] [EC:2.3.1.48]
137017363  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
137017372  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
137017505  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
137017777  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
137018511  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
137018560  bmp2b; bone morphogenetic protein 2b [KO:K21283]
137019006  thbs1b; thrombospondin-1 isoform X1 [KO:K16857]
137019010  grem1a; gremlin-1a [KO:K23318]
137019017  id2b; DNA-binding protein inhibitor ID-2b [KO:K17693]
137019091  lft1; lefty1 [KO:K04668]
137020200  bmp5; bone morphogenetic protein 5 [KO:K04663]
137020236  smad5; mothers against decapentaplegic homolog 5 [KO:K16790]
137020504  bmpr1aa; bone morphogenetic protein receptor, type IAa isoform X1 [KO:K04673] [EC:2.7.11.30]
137020917  [KO:K22687]
137020961  emp3a; epithelial membrane protein 3 [KO:K26257]
137021065  skib; v-ski avian sarcoma viral oncogene homolog b [KO:K26503]
137021123  id1; DNA-binding protein inhibitor ID-1 [KO:K04680]
137021149  zfyve9b; zinc finger FYVE domain-containing protein 9 [KO:K04679]
137021183  bmp7a; bone morphogenetic protein 7a isoform X1 [KO:K16621]
137021584  fmoda; fibromodulin a [KO:K08121]
137021797  sp1; transcription factor Sp1 isoform X1 [KO:K04684]
137022535  bmp16; bone morphogenetic protein 16 [KO:K21283]
137022548  ppp2caa; protein phosphatase 2 catalytic subunit alpha a [KO:K04382] [EC:3.1.3.16]
137022859  rgma; repulsive guidance molecule A [KO:K23096]
137022996  [KO:K23377]
137023240  si:dkey-5i3.5; transmembrane protein 53 isoform X1 [KO:K28359]
137023355  smad6b; mothers against decapentaplegic homolog 6b [KO:K04677]
137023356  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
137023500  fbn1; fibrillin-1 isoform X1 [KO:K06825]
137023882  ifng1; interferon gamma 1 [KO:K04687]
137024375  lemd3; inner nuclear membrane protein Man1 [KO:K19410]
137024419  dcn; decorin [KO:K04660]
137024853  id4; DNA-binding protein inhibitor ID-4 [KO:K17695]
137026477  gdf6a; growth/differentiation factor 6-A [KO:K20012]
137026582  fmodb; fibromodulin [KO:K08121]
137026918  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
137026952  skia; v-ski avian sarcoma viral oncogene homolog a [KO:K26503]
137027114  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
137027153  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
137027491  fstb; follistatin b [KO:K04661]
137027750  amh; muellerian-inhibiting factor [KO:K04665]
137027824  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
137027896  hjv; hemojuvelin [KO:K23100]
137028439  [KO:K04513]
137028465  lrrc32; transforming growth factor beta activator LRRC32 [KO:K26316]
137028476  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
137028480  bmpr1bb; bone morphogenetic protein receptor, type IBb [KO:K13578] [EC:2.7.11.30]
137028503  zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
137028666  smad9; mothers against decapentaplegic homolog 9 isoform X1 [KO:K16791]
137028719  rps6kb1a; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
137028917  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
137028965  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
137029148  rgmd; RGM domain family, member D [KO:K23096]
137029324  nbl1; neuroblastoma suppressor of tumorigenicity 1 isoform X1 [KO:K19558]
137029998  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
137030074  neo1a; neogenin 1a isoform X1 [KO:K06766]
137030428  smad6a; mothers against decapentaplegic homolog 6a [KO:K04677]
137031228  sin3ab; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
137031379  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
137031819  smad1; mothers against decapentaplegic homolog 1 isoform X1 [KO:K04676]
137032771  tgfbr2b; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
137032789  adamtsl7; thrombospondin type-1 domain-containing protein 4 [KO:K23377]
137032869  tfdp1b; transcription factor Dp-1b [KO:K04683]
137033586  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
137033605  bmpr1ba; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
137033938  smad4b; mothers against decapentaplegic homolog 4 [KO:K04501]
137034238  ppp2r1ba; protein phosphatase 2, regulatory subunit A, beta a [KO:K03456]
137034275  fsta; follistatin-A [KO:K04661]
137034447  ncor1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
137034627  rgmb; RGM domain family member B [KO:K06847]
137034677  smad10b; mothers against decapentaplegic homolog 4 [KO:K04501]
137034932  spaw; southpaw [KO:K04666]
137035371  [KO:K04675] [EC:2.7.11.30]
137035754  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
137035779  [KO:K13568] [EC:2.7.11.30]
137035793  inhbb; inhibin beta B chain isoform X1 [KO:K22687]
137036064  bmpr2b; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
137036471  tfdp1a; transcription factor Dp-1a isoform X1 [KO:K04683]
137036515  acvr2aa; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
137037220  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
137037242  hdac1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
137037247  smad10a; mothers against decapentaplegic homolog 4 [KO:K04501]
137037714  hamp; hepcidin-1 isoform X1 [KO:K23106]
137037746  gdf6b; growth/differentiation factor 6-B isoform X1 [KO:K20012]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
cery04010  MAPK signaling pathway
cery04110  Cell cycle
cery04120  Ubiquitin mediated proteolysis
cery04210  Apoptosis
KO pathway
ko04350   

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