KEGG   PATHWAY: cimi04972
Entry
cimi04972                   Pathway                                
Name
Pancreatic secretion - Cebus imitator (Panamanian white-faced capuchin)
Description
The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
Class
Organismal Systems; Digestive system
Pathway map
cimi04972  Pancreatic secretion
cimi04972

Other DBs
GO: 0030157
Organism
Cebus imitator (Panamanian white-faced capuchin) [GN:cimi]
Gene
108281387  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
108281637  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
108281995  RAB3D; ras-related protein Rab-3D [KO:K07884]
108282129  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
108282190  RAB27B; ras-related protein Rab-27B [KO:K07886]
108282733  BST1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X1 [KO:K18152] [EC:3.2.2.6 2.4.99.20]
108282737  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
108283295  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
108283495  CLCA2; calcium-activated chloride channel regulator 2 [KO:K05028]
108283498  CLCA1; calcium-activated chloride channel regulator 1 [KO:K05027]
108283499  CLCA4; calcium-activated chloride channel regulator 4 isoform X1 [KO:K05030]
108283500  [KO:K05030]
108283502  [KO:K05030]
108283721  SCTR; secretin receptor isoform X2 [KO:K04588]
108283815  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
108284306  SLC12A2; solute carrier family 12 member 2 isoform X1 [KO:K10951]
108284461  RAB8A; ras-related protein Rab-8A [KO:K07901]
108284655  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
108284740  SLC4A4; electrogenic sodium bicarbonate cotransporter 1 isoform X1 [KO:K13575]
108285730  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
108285822  CELA3B; chymotrypsin-like elastase family member 3B [KO:K01345] [EC:3.4.21.70]
108285878  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
108285919  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X5 [KO:K04632]
108285920  [KO:K04632]
108286038  [KO:K01539] [EC:7.2.2.13]
108286109  [KO:K01539] [EC:7.2.2.13]
108286553  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
108286852  [KO:K01346] [EC:3.4.21.71]
108286965  CCKAR; cholecystokinin receptor type A [KO:K04194]
108287700  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
108287708  PLA2G5; phospholipase A2 group V isoform X2 [KO:K01047] [EC:3.1.1.4]
108287729  PLA2G2D; group IID secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
108287739  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
108288162  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
108288737  KCNQ1; potassium voltage-gated channel subfamily KQT member 1 [KO:K04926]
108288783  SCT; secretin [KO:K05263]
108288965  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
108289906  PLA2G12A; group XIIA secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
108290403  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
108291136  PRSS2; trypsin-2 [KO:K01312] [EC:3.4.21.4]
108291165  [KO:K01312] [EC:3.4.21.4]
108291736  [KO:K05853] [EC:7.2.2.10]
108292033  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108292186  ATP2B1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
108292224  [KO:K01176] [EC:3.2.1.1]
108292226  [KO:K01176] [EC:3.2.1.1]
108292255  RAB11A; ras-related protein Rab-11A [KO:K07904]
108294141  TPCN2; LOW QUALITY PROTEIN: two pore calcium channel protein 2 [KO:K14077]
108294452  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
108294725  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
108295411  CEL; bile salt-activated lipase [KO:K12298] [EC:3.1.1.3 3.1.1.13]
108295412  [KO:K12298] [EC:3.1.1.3 3.1.1.13]
108296149  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
108296753  [KO:K04513]
108297662  SLC4A2; anion exchange protein 2 isoform X1 [KO:K13855]
108297937  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
108298696  [KO:K04632]
108299489  CA2; carbonic anhydrase 2 [KO:K18245] [EC:4.2.1.1]
108300031  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X3 [KO:K04960]
108300232  RAP1B; ras-related protein Rap-1b [KO:K07836]
108300580  [KO:K01538]
108300822  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
108300836  TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
108300863  CPB1; carboxypeptidase B [KO:K01291] [EC:3.4.17.2]
108300865  CPA3; mast cell carboxypeptidase A [KO:K08780] [EC:3.4.17.1]
108300913  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
108300966  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
108301141  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
108301226  RAP1A; ras-related protein Rap-1A [KO:K04353]
108301433  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
108302012  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
108302209  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
108302623  RYR2; ryanodine receptor 2 [KO:K04962]
108303190  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
108303482  [KO:K04392]
108305477  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
108305731  [KO:K01310] [EC:3.4.21.1]
108305801  [KO:K01310] [EC:3.4.21.1]
108306142  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
108306561  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X2 [KO:K01540]
108306963  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
108307247  CPA1; carboxypeptidase A1 isoform X1 [KO:K08779] [EC:3.4.17.1]
108307250  CPA2; carboxypeptidase A2 [KO:K01298] [EC:3.4.17.15]
108307873  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108308335  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
108308532  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108308813  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
108308994  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
108309486  CPB2; carboxypeptidase B2 [KO:K01300] [EC:3.4.17.20]
108310295  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
108311356  [KO:K01047] [EC:3.1.1.4]
108311827  CTRL; chymotrypsin-like protease CTRL-1 [KO:K09632] [EC:3.4.21.-]
108312214  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
108312815  CCK; cholecystokinin [KO:K05226]
108313503  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
108314366  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
108314770  [KO:K14075] [EC:3.1.1.3]
108314771  PNLIPRP1; inactive pancreatic lipase-related protein 1 [KO:K14074] [EC:3.1.1.3]
108314772  [KO:K14073] [EC:3.1.1.3]
108315772  [KO:K01540]
108316024  ADCY6; LOW QUALITY PROTEIN: adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
108316757  SLC26A3; chloride anion exchanger isoform X1 [KO:K14078]
Compound
C00001  H2O
C00011  CO2
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00288  HCO3-
C00575  3',5'-Cyclic AMP
C00698  Cl-
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01353  Carbonic acid
C01996  Acetylcholine
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:17850212
  Authors
Petersen OH, Tepikin AV
  Title
Polarized calcium signaling in exocrine gland cells.
  Journal
Annu Rev Physiol 70:273-99 (2008)
DOI:10.1146/annurev.physiol.70.113006.100618
Reference
PMID:20625287
  Authors
Williams JA
  Title
Regulation of acinar cell function in the pancreas.
  Journal
Curr Opin Gastroenterol 26:478-83 (2010)
DOI:10.1097/MOG.0b013e32833d11c6
Reference
PMID:16891880
  Authors
Williams JA
  Title
Regulation of pancreatic acinar cell function.
  Journal
Curr Opin Gastroenterol 22:498-504 (2006)
DOI:10.1097/01.mog.0000239863.96833.c0
Reference
PMID:15689674
  Authors
Bi Y, Williams JA
  Title
Receptor biology and signal transduction in pancreatic acinar cells.
  Journal
Curr Opin Gastroenterol 20:427-34 (2004)
DOI:10.1097/00001574-200409000-00002
Reference
PMID:14660554
  Authors
Yamasaki M, Masgrau R, Morgan AJ, Churchill GC, Patel S, Ashcroft SJ, Galione A
  Title
Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
  Journal
J Biol Chem 279:7234-40 (2004)
DOI:10.1074/jbc.M311088200
Reference
PMID:9548666
  Authors
Kanno T
  Title
Ca2+ signaling in the pancreatic acinus.
  Journal
Pancreas 16:273-6 (1998)
Reference
PMID:18626068
  Authors
Heitzmann D, Warth R
  Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
  Journal
Physiol Rev 88:1119-82 (2008)
DOI:10.1152/physrev.00020.2007
Reference
PMID:14637169
  Authors
Konturek SJ, Zabielski R, Konturek JW, Czarnecki J
  Title
Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion.
  Journal
Eur J Pharmacol 481:1-14 (2003)
DOI:10.1016/j.ejphar.2003.08.042
Reference
PMID:16888148
  Authors
Chu JY, Yung WH, Chow BK
  Title
Secretin: a pleiotrophic hormone.
  Journal
Ann N Y Acad Sci 1070:27-50 (2006)
DOI:10.1196/annals.1317.013
Reference
PMID:16930743
  Authors
Siu FK, Lam IP, Chu JY, Chow BK
  Title
Signaling mechanisms of secretin receptor.
  Journal
Regul Pept 137:95-104 (2006)
DOI:10.1016/j.regpep.2006.02.011
Reference
PMID:15709963
  Authors
Steward MC, Ishiguro H, Case RM
  Title
Mechanisms of bicarbonate secretion in the pancreatic duct.
  Journal
Annu Rev Physiol 67:377-409 (2005)
DOI:10.1146/annurev.physiol.67.031103.153247
Reference
PMID:20224219
  Authors
Kim D, Steward MC
  Title
The role of CFTR in bicarbonate secretion by pancreatic duct and airway epithelia.
  Journal
J Med Invest 56 Suppl:336-42 (2009)
DOI:10.2152/jmi.56.336
Reference
PMID:17205399
  Authors
Whitcomb DC, Lowe ME
  Title
Human pancreatic digestive enzymes.
  Journal
Dig Dis Sci 52:1-17 (2007)
DOI:10.1007/s10620-006-9589-z
Reference
PMID:10835353
  Authors
Cancela JM, Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH
  Title
Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
  Journal
EMBO J 19:2549-57 (2000)
DOI:10.1093/emboj/19.11.2549
Reference
PMID:10078532
  Authors
Cancela JM, Churchill GC, Galione A
  Title
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
  Journal
Nature 398:74-6 (1999)
DOI:10.1038/18032
Reference
PMID:11087843
  Authors
Parekh AB
  Title
Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger.
  Journal
Proc Natl Acad Sci U S A 97:12933-4 (2000)
DOI:10.1073/pnas.97.24.12933
Reference
PMID:19088252
  Authors
Williams JA, Chen X, Sabbatini ME
  Title
Small G proteins as key regulators of pancreatic digestive enzyme secretion.
  Journal
Am J Physiol Endocrinol Metab 296:E405-14 (2009)
DOI:10.1152/ajpendo.90874.2008
Related
pathway
cimi04020  Calcium signaling pathway
cimi04530  Tight junction
cimi04973  Carbohydrate digestion and absorption
cimi04974  Protein digestion and absorption
cimi04975  Fat digestion and absorption
cimi04977  Vitamin digestion and absorption
KO pathway
ko04972   

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