KEGG   PATHWAY: cmao04530
Entry
cmao04530                   Pathway                                
Name
Tight junction - Colossoma macropomum (tambaqui)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
cmao04530  Tight junction
cmao04530

Other DBs
GO: 0005923
Organism
Colossoma macropomum (tambaqui) [GN:cmao]
Gene
118796697  pard3ab; par-3 family cell polarity regulator alpha, b isoform X1 [KO:K04237]
118796739  [KO:K05719]
118796740  dlg1l; discs large homolog 1-like protein isoform X1 [KO:K12076]
118796805  cldn15la; claudin 15-like a [KO:K06087]
118796811  [KO:K06087]
118796937  actn4; LOW QUALITY PROTEIN: alpha-actinin-4 [KO:K05699]
118796950  rab8a; ras-related protein Rab-8A [KO:K07901]
118796988  [KO:K06087]
118796994  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
118796996  arhgef2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
118797002  amotl1; angiomotin-like protein 1 isoform X1 [KO:K06104]
118797007  [KO:K05719]
118797069  cldnj; claudin j [KO:K06087]
118797122  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
118797156  [KO:K06087]
118797222  [KO:K06087]
118797281  [KO:K06087]
118797287  [KO:K06087]
118797288  [KO:K06087]
118797335  [KO:K06087]
118797386  cldnf; claudin f [KO:K06087]
118797667  micall2b; protein-methionine sulfoxide oxidase mical2b isoform X1 [KO:K21068]
118797821  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118797846  [KO:K05762]
118797872  tiam1b; LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
118797901  jam2a; junctional adhesion molecule 2A isoform X1 [KO:K06735]
118798013  actr2a; actin-related protein 2-A [KO:K17260]
118798054  cldn8; claudin-8 [KO:K06087]
118798144  runx1; runt-related transcription factor 1 isoform X1 [KO:K08367]
118798271  actb1; actin, cytoplasmic 1 [KO:K05692]
118798670  [KO:K07200]
118798702  cldn15lb; claudin 15-like b isoform X1 [KO:K06087]
118798710  epb41l4b; band 4.1-like protein 4B [KO:K21111]
118798856  cldn11b; claudin-11b [KO:K06087]
118799213  cldn12; claudin-12 [KO:K06087]
118799272  [KO:K05704] [EC:2.7.10.2]
118799305  [KO:K07374]
118799306  [KO:K07374]
118799307  [KO:K07374]
118799366  magi1b; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1b isoform X1 [KO:K05631]
118799410  [KO:K04513]
118799432  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
118799464  arpc4l; actin related protein 2/3 complex, subunit 4, like [KO:K05755]
118799483  rap1ab; ras-related protein rap1ab [KO:K04353]
118799526  [KO:K04851]
118799596  cldn19; claudin-19 isoform X1 [KO:K06087]
118799717  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
118800280  jam3a; junctional adhesion molecule 3B isoform X1 [KO:K06785]
118800503  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
118800999  [KO:K04426] [EC:2.7.11.25]
118801336  pard6a; LOW QUALITY PROTEIN: partitioning defective 6 homolog alpha [KO:K06093]
118801736  zgc:101810; actin-related protein 2-B [KO:K17260]
118801932  [KO:K06087]
118802034  [KO:K06087]
118802038  [KO:K06087]
118802040  cldn10b; claudin-10 isoform X1 [KO:K06087]
118802319  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
118802406  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
118802419  arpc5lb; actin related protein 2/3 complex, subunit 5-like, b isoform X1 [KO:K05754]
118802941  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118802950  [KO:K07374]
118803064  cldng; claudin-like protein ZF-A9 [KO:K06087]
118803206  [KO:K06087]
118803534  tuba8l2; tubulin, alpha 8 like 2 [KO:K07374]
118803995  [KO:K20479]
118804712  arpc5a; actin-related protein 2/3 complex subunit 5a [KO:K05754]
118804730  amotl2b; angiomotin-like protein 2b [KO:K06104]
118804739  cldn18; claudin-18 [KO:K06087]
118804772  cldn11a; claudin-11a [KO:K06087]
118805284  pard6gb; par-6 family cell polarity regulator gamma b [KO:K06093]
118805306  [KO:K10352]
118805680  [KO:K06087]
118805693  llgl1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
118805712  actb2; actin, cytoplasmic 2 [KO:K05692]
118805719  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
118805720  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
118805744  micall2a; MICAL-like protein 2a isoform X1 [KO:K21068]
118805943  [KO:K04393]
118805951  cgnb; cingulin isoform X1 [KO:K06102]
118806030  arhgef1a; rho guanine nucleotide exchange factor 1a isoform X1 [KO:K12791]
118806091  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
118806097  crb3a; protein crumbs homolog 3a [KO:K06090]
118806104  cldnk; claudin k [KO:K06087]
118806183  [KO:K07374]
118806630  actr3; actin-related protein 3 [KO:K18584]
118806829  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
118806898  [KO:K04354]
118806949  [KO:K07374]
118806958  [KO:K07374]
118806979  [KO:K07374]
118807008  rapgef2; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [KO:K08018]
118807055  ppp2r2cb; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
118807170  dlg3; disks large homolog 3 isoform X1 [KO:K21098]
118807215  rap2c; ras-related protein Rap-2c [KO:K07839]
118807253  msnb; moesin b [KO:K05763]
118807444  cldn34a; claudin-34 [KO:K06087]
118807446  si:ch211-181l5.2; claudin-10 [KO:K06087]
118807484  mpp4b; MAGUK p55 subfamily member 4 [KO:K21109]
118807519  [KO:K06087]
118807524  si:busm1-52i16.2; claudin-10 [KO:K06087]
118807994  dlg1; disks large homolog 1 isoform X1 [KO:K12076]
118808035  amotl2a; angiomotin-like 2a [KO:K06104]
118808075  [KO:K07374]
118808077  [KO:K07374]
118808087  cldn10a; claudin-10a [KO:K06087]
118808111  [KO:K05758]
118808147  [KO:K10352]
118808153  myh9a; myosin-9a [KO:K10352]
118808274  myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
118808310  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
118808383  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
118808407  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
118808426  rhoca; ras homolog family member Ca [KO:K04513]
118808660  myh11a; myosin-11a isoform X1 [KO:K10352]
118809091  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
118809209  [KO:K04392]
118809266  prkcea; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
118809293  slc9a3r1a; Na(+)/H(+) exchange regulatory cofactor NHE-RF1a [KO:K13365]
118809386  llgl2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
118809607  arhgap17a; rho GTPase-activating protein 17a isoform X1 [KO:K20638]
118809704  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118809785  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118810174  actr2b; actin-related protein 2-B isoform X1 [KO:K17260]
118810192  tjap1; tight junction-associated protein 1 [KO:K06105]
118810223  prkceb; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
118810288  [KO:K21109]
118810413  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118811008  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
118811048  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
118811424  hspa4b; heat shock 70 kDa protein 4b [KO:K09489]
118811679  [KO:K07902]
118811706  tjp1b; tight junction protein ZO-1 [KO:K05701]
118811818  [KO:K21110]
118812146  ppp2caa; protein phosphatase 2 catalytic subunit alpha a [KO:K04382] [EC:3.1.3.16]
118812155  [KO:K21112]
118812246  [KO:K05758]
118812315  hcls1; hematopoietic lineage cell-specific protein isoform X1 [KO:K06106]
118812921  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
118813077  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b isoform X1 [KO:K07199]
118813096  arpc5la; actin related protein 2/3 complex, subunit 5-like, a [KO:K05754]
118813206  wasb; LOW QUALITY PROTEIN: WASP actin nucleation promoting factor b [KO:K05747]
118813381  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
118813393  [KO:K05631]
118813406  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
118813414  tuba5; tubulin alpha 5 [KO:K07374]
118813459  ppp2r2aa; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
118813472  cldn5a; claudin 5a [KO:K06087]
118813650  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
118813692  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
118813763  wasa; neural Wiskott-Aldrich syndrome protein [KO:K05747]
118813840  [KO:K06098]
118813978  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
118813994  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
118814002  si:ch73-61d6.3; occludin [KO:K06088]
118814097  pard6ga; par-6 family cell polarity regulator gamma a [KO:K06093]
118814291  ppp2r1ba; protein phosphatase 2, regulatory subunit A, beta a [KO:K03456]
118814322  sympk; symplekin [KO:K06100]
118814526  msna; moesin a [KO:K05763]
118814743  f11r.1; F11 receptor, tandem duplicate 1 [KO:K06089]
118814800  myl2a; myosin regulatory light chain 2a [KO:K10351]
118814879  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
118814938  [KO:K06087]
118814939  [KO:K06087]
118815433  jun; transcription factor AP-1 [KO:K04448]
118815456  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
118815474  si:ch211-191a24.4; MARVEL domain-containing protein 3 [KO:K21099]
118815562  actr3b; actin-related protein 3B [KO:K18584]
118815731  afdna; afadin isoform X1 [KO:K05702]
118815821  mpp5b; MAGUK p55 subfamily member 5b [KO:K06091]
118815882  gata4; transcription factor GATA-4 [KO:K09183]
118815917  rock2b; LOW QUALITY PROTEIN: rho-associated protein kinase 2b [KO:K17388] [EC:2.7.11.39]
118815919  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
118816191  [KO:K06087]
118816236  pard3aa; partitioning defective 3 homolog isoform X1 [KO:K04237]
118816289  itgb1a; LOW QUALITY PROTEIN: integrin beta-1a [KO:K05719]
118816528  si:dkey-253i9.4; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
118816662  [KO:K06095]
118816823  si:dkey-92j12.5; multiple PDZ domain protein [KO:K06095]
118817043  ppp2r2ca; protein phosphatase 2, regulatory subunit B, gamma a [KO:K04354]
118817421  tjp1a; tight junction protein ZO-1 isoform X1 [KO:K05701]
118817568  cgnl1; cingulin-like protein 1 isoform X1 [KO:K21110]
118817736  cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
118817877  nedd4a; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NEDD4a [KO:K10591] [EC:2.3.2.26]
118817981  [KO:K06106]
118818018  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
118818607  patj; inaD-like protein isoform X1 [KO:K06092]
118818739  [KO:K06087]
118818861  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
118818888  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
118818890  arhgef18b; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
118818891  bves; blood vessel epicardial substance [KO:K21108]
118819183  [KO:K06087]
118819190  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
118819426  tjp3; tight junction protein ZO-3 isoform X1 [KO:K06097]
118819428  [KO:K06087]
118819524  marveld3; MARVEL domain-containing protein 3 [KO:K21099]
118819644  nf2b; neurofibromin 2b (merlin) [KO:K16684]
118819645  zgc:136892; claudin-4 [KO:K06087]
118819647  [KO:K06087]
118819714  nedd4l; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
118819720  ppp2r2bb; protein phosphatase 2, regulatory subunit B, beta b isoform X1 [KO:K04354]
118819890  cldnc; claudin c [KO:K06087]
118819891  cldnh; claudin h [KO:K06087]
118819897  amot; angiomotin isoform X1 [KO:K16819]
118819951  [KO:K08020]
118819973  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
118819992  hspa4a; heat shock 70 kDa protein 4a [KO:K09489]
118819999  cldn2; claudin-2 [KO:K06087]
118820022  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118820172  [KO:K06087]
118820173  [KO:K06087]
118820198  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
118820320  cldnb; claudin b [KO:K06087]
118820350  jam3b; junctional adhesion molecule 3B [KO:K06785]
118820354  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118820454  [KO:K06087]
118820543  cdc42l; cell division cycle 42, like [KO:K04393]
118820883  [KO:K05692]
118820928  zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
118820963  jam2b; junctional adhesion molecule 2b [KO:K06735]
118821068  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
118821152  cldni; claudin i [KO:K06087]
118821493  slc9a3r1b; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
118821648  arhgap17b; rho GTPase-activating protein 17b isoform X1 [KO:K20638]
118822038  tuba1c; tubulin alpha-1C chain [KO:K07374]
118822042  pard6b; partitioning defective 6 homolog beta [KO:K06093]
118822050  zgc:153867; myosin light polypeptide 6 isoform X1 [KO:K12751]
118822088  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
118822125  tuba1a; tubulin alpha-1A chain [KO:K07374]
118822126  [KO:K07374]
118822154  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
118822281  [KO:K06087]
118822292  [KO:K06087]
118822297  myl9a; myosin regulatory light polypeptide 9 [KO:K12755]
118822446  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
118822750  [KO:K06087]
118822751  [KO:K06087]
118822895  [KO:K06087]
118822896  [KO:K06087]
118822897  [KO:K06087]
118823244  [KO:K06087]
118823248  [KO:K06102]
118823424  ezra; ezrin a isoform X1 [KO:K08007]
118823440  rab13; ras-related protein Rab-13 [KO:K06109]
118824187  mpp5a; MAGUK p55 subfamily member 5-A [KO:K06091]
118824270  marveld2a; MARVEL domain-containing protein 2 [KO:K17291]
118824271  oclna; occludin [KO:K06088]
118824319  vaspa; vasodilator stimulated phosphoprotein a [KO:K06274]
118824390  tjp2a; tight junction protein ZO-2a isoform X1 [KO:K06098]
118824432  tuba7l; tubulin, alpha 7 like [KO:K07374]
118824466  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
118824487  tiam1a; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
118824728  ppp2r2ab; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
118824909  cldn7b; claudin-7-B [KO:K06087]
118824925  pcna; proliferating cell nuclear antigen [KO:K04802]
118824946  cldn5b; claudin-5b [KO:K06087]
118824972  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
118825037  igsf5a; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
118825293  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
118825561  prkag2b; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
118825617  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
118825629  cldn1; claudin-1 [KO:K06087]
118825662  cldn15a; claudin-15a [KO:K06087]
118825671  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
118825675  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
118825783  arhgef18a; rho guanine nucleotide exchange factor 18a [KO:K21066]
118826029  cldn7a; claudin-7-A [KO:K06087]
118826033  scrib; protein scribble homolog isoform X1 [KO:K16175]
118826508  [KO:K12757]
118826637  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
118827101  zgc:110333; claudin-8 [KO:K06087]
118827106  [KO:K06087]
118827210  nf2a; neurofibromin 2a (merlin) [KO:K16684]
118827333  oclnb; occludin b [KO:K06088]
118827522  marveld2b; MARVEL domain-containing protein 2b [KO:K17291]
118827585  si:dkey-98f17.3; putative claudin-24 [KO:K06087]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
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Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
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Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
cmao04520  Adherens junction
cmao04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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