KEGG   PATHWAY: cmk00280
Entry
cmk00280                    Pathway                                
Name
Valine, leucine and isoleucine degradation - Callorhinchus milii (elephant shark)
Class
Metabolism; Amino acid metabolism
Pathway map
cmk00280  Valine, leucine and isoleucine degradation
cmk00280

Module
cmk_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:cmk00280]
cmk_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:cmk00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Callorhinchus milii (elephant shark) [GN:cmk]
Gene
103181086  bcat1; branched-chain-amino-acid aminotransferase, cytosolic isoform X1 [KO:K00826] [EC:2.6.1.42]
103190155  bcat2; branched-chain-amino-acid aminotransferase, mitochondrial [KO:K00826] [EC:2.6.1.42]
103172759  bckdha; 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial isoform X1 [KO:K00166] [EC:1.2.4.4]
103186186  bckdhb; 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform X1 [KO:K00167] [EC:1.2.4.4]
103184741  dbt; lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform X1 [KO:K09699] [EC:2.3.1.168]
103189342  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
103182182  acads; short-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00248] [EC:1.3.8.1]
103174736  acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
103176193  ivd; isovaleryl-CoA dehydrogenase, mitochondrial [KO:K00253] [EC:1.3.8.4]
103185437  acadsb; short/branched chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K09478] [EC:1.3.8.5]
103180256  acad8; isobutyryl-CoA dehydrogenase, mitochondrial [KO:K11538] [EC:1.3.99.-]
103183149  trifunctional enzyme subunit alpha, mitochondrial [KO:K07515] [EC:4.2.1.17 1.1.1.211]
103182105  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
103182114  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
103191285  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
103187341  acaa2; 3-ketoacyl-CoA thiolase, mitochondrial [KO:K07508] [EC:2.3.1.16]
103183148  hadhb; trifunctional enzyme subunit beta, mitochondrial [KO:K07509] [EC:2.3.1.16]
103186998  pcca; propionyl-CoA carboxylase alpha chain, mitochondrial [KO:K01965] [EC:6.4.1.3]
103174815  pccb; propionyl-CoA carboxylase beta chain, mitochondrial [KO:K01966] [EC:6.4.1.3 2.1.3.15]
103179162  mcee; methylmalonyl-CoA epimerase, mitochondrial [KO:K05606] [EC:5.1.99.1]
103184982  mmut; methylmalonyl-CoA mutase, mitochondrial isoform X1 [KO:K01847] [EC:5.4.99.2]
103176535  hibch; 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial [KO:K05605] [EC:3.1.2.4]
103183161  hibadhb; LOW QUALITY PROTEIN: 3-hydroxyisobutyrate dehydrogenase b [KO:K00020] [EC:1.1.1.31]
103186796  aldh6a1; methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial [KO:K00140] [EC:1.2.1.18 1.2.1.27]
103189441  aldh16a1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
103186924  aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00128] [EC:1.2.1.3]
103184053  aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
103182361  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
103180031  aldh9a1a.1; 4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
103188085  acsf3; malonate--CoA ligase ACSF3, mitochondrial [KO:K18660] [EC:6.2.1.76 6.2.1.-]
103178828  abat; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
103187990  mccc1; LOW QUALITY PROTEIN: methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial [KO:K01968] [EC:6.4.1.4]
103182695  mccc2; methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [KO:K01969] [EC:6.4.1.4]
103189135  si:ch211-198n5.11; methylcrotonoyl-coenzyme A carboxylase 2 [KO:K01969] [EC:6.4.1.4]
103182861  auh; methylglutaconyl-CoA hydratase, mitochondrial [KO:K05607] [EC:4.2.1.18]
103188695  hmgcl; hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X1 [KO:K01640] [EC:4.1.3.4]
103179011  hmgcll1; 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic [KO:K01640] [EC:4.1.3.4]
103184387  aacs; acetoacetyl-CoA synthetase isoform X1 [KO:K01907] [EC:6.2.1.16]
103178593  LOW QUALITY PROTEIN: acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
103186520  acat1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
103191217  acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
121848070  acetyl-CoA acetyltransferase, cytosolic-like [KO:K00626] [EC:2.3.1.9]
103173382  hmgcs1; LOW QUALITY PROTEIN: hydroxymethylglutaryl-CoA synthase, cytoplasmic [KO:K01641] [EC:2.3.3.10]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
cmk00020  Citrate cycle (TCA cycle)
cmk00240  Pyrimidine metabolism
cmk00290  Valine, leucine and isoleucine biosynthesis
cmk00640  Propanoate metabolism
cmk00900  Terpenoid backbone biosynthesis
KO pathway
ko00280   
LinkDB

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