KEGG   PATHWAY: dre04310
Entry
dre04310                    Pathway                                
Name
Wnt signaling pathway - Danio rerio (zebrafish)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
dre04310  Wnt signaling pathway
dre04310

Other DBs
GO: 0016055
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
333999  porcnl; porcupine O-acyltransferase like [KO:K00181] [EC:2.3.1.250]
100006275  porcn; protein-serine O-palmitoleoyltransferase porcupine [KO:K00181] [EC:2.3.1.250]
30128  wnt1; protein Wnt-1 precursor [KO:K03209]
359837  wnt2ba; wingless-type MMTV integration site family, member 2Ba [KO:K00182]
556087  wnt2bb; wingless-type MMTV integration site family, member 2Bb [KO:K00182]
30127  wnt2; protein Wnt-2 precursor [KO:K00182]
569420  wnt3; proto-oncogene Wnt-3 [KO:K00312]
60632  wnt3a; protein Wnt-3a precursor [KO:K00312]
30123  wnt4; protein Wnt-4a precursor [KO:K00408]
791993  wnt4b; wingless-type MMTV integration site family, member 4b precursor [KO:K00408]
30105  wnt5b; protein Wnt-5b precursor [KO:K00444]
568191  wnt5a; protein Wnt-5a [KO:K00444]
100332722  wnt6a; protein Wnt-6-like [KO:K00445]
561831  wnt6b; protein Wnt-6 [KO:K00445]
565714  wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572]
100148840  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
563427  wnt7ba; protein Wnt-7b [KO:K00572]
568110  protein Wnt-7a-like [KO:K00572]
30122  wnt8a; protein Wnt-8a ORF1 precursor [KO:K00714]
30144  wnt8b; protein Wnt-8b precursor [KO:K00714]
553976  wnt8-2; protein Wnt-8a ORF2 precursor [KO:K00714]
751644  wnt9a; protein Wnt-9a precursor [KO:K01064]
565677  wnt9b; protein Wnt-9b precursor [KO:K01064]
30308  wnt10b; protein Wnt-10b precursor [KO:K01357]
30171  wnt10a; protein Wnt-10a [KO:K01357]
30283  wnt11; protein Wnt-11 precursor [KO:K01384]
791595  wnt11f2; protein Wnt-11 precursor [KO:K01384]
791563  wnt16; protein Wnt-16 precursor [KO:K01558]
791454  dand5; DAN domain family member 5 precursor [KO:K01645]
570510  notum1a; palmitoleoyl-protein carboxylesterase notum1a precursor [KO:K19882] [EC:3.1.1.98]
566040  notum2; carboxylesterase notum2 precursor [KO:K19882] [EC:3.1.1.98]
436917  notum1b; inactive palmitoleoyl-protein carboxylesterase notum1b precursor [KO:K19882] [EC:3.1.1.98]
30476  wif1; wnt inhibitory factor 1 precursor [KO:K01691]
100000500  sost; sclerostin [KO:K16834]
30197  dkk1b; dickkopf-related protein 1b precursor [KO:K02165]
792404  dkk2; dickkopf-related protein 2 precursor [KO:K02165]
799377  dkk1a; dickkopf WNT signaling pathway inhibitor 1a precursor [KO:K02165]
447800  serpinf1; pigment epithelium-derived factor precursor [KO:K19614]
402843  sfrp1a; secreted frizzled-related protein 1a precursor [KO:K02166]
798564  sfrp1b; secreted frizzled-related protein 1b precursor [KO:K02166]
566878  sfrp2; secreted frizzled-related protein 2 precursor [KO:K02176]
100538205  sfrp2l; secreted frizzled-related protein 2-like [KO:K02176]
30119  frzb; secreted frizzled-related protein 3 precursor [KO:K25481]
117510  sfrp5; secreted frizzled-related protein 5 precursor [KO:K02222]
436625  rspo1; R-spondin-1 precursor [KO:K19471]
566054  rspo2; R-spondin-2 precursor [KO:K23097]
100007702  rspo3; R-spondin-3 precursor [KO:K23098]
558825  lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 precursor [KO:K04309]
100330212  lgr6; leucine-rich repeat-containing G-protein coupled receptor 6 precursor [KO:K08399]
103909653  leucine-rich repeat-containing G-protein coupled receptor 6-like [KO:K08399]
572332  rnf43; E3 ubiquitin-protein ligase RNF43 [KO:K15694] [EC:2.3.2.27]
556813  znrf3; E3 ubiquitin-protein ligase znrf3 precursor [KO:K16273] [EC:2.3.2.27]
30412  fzd7b; frizzled-7b precursor [KO:K02432]
30369  fzd7a; frizzled-7a precursor [KO:K02432]
557384  fzd1; frizzled-1 precursor [KO:K02432]
30370  fzd2; frizzled-2 precursor [KO:K02235]
565921  fzd3a; frizzled-3a precursor [KO:K02329]
567746  fzd3b; frizzled-3b precursor [KO:K02329]
30363  fzd4; frizzled-4 precursor [KO:K02354]
30364  fzd5; frizzled-5 precursor [KO:K02375]
58073  fzd8a; frizzled-8a precursor [KO:K02375]
58072  fzd8b; frizzled-8b precursor [KO:K02375]
393533  fzd6; frizzled-6 precursor [KO:K02376]
30366  fzd10; frizzled-10 precursor [KO:K02842]
58023  fzd9b; frizzled-9b precursor [KO:K02842]
557447  fzd9a; frizzled-9 [KO:K02842]
100003877  lrp6; low-density lipoprotein receptor-related protein 6 precursor [KO:K03068]
568518  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
83496  bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a precursor [KO:K10162]
431736  bambib; BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b precursor [KO:K10162]
100332639  protein APCDD1-like [KO:K25812]
100001408  apcdd1l; protein APCDD1-like [KO:K25812]
100006858  csnk1e; casein kinase I isoform epsilon [KO:K08960] [EC:2.7.11.1]
553231  ccdc88c; protein Daple [KO:K25811]
323630  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
560032  dvl1b; segment polarity protein dishevelled homolog DVL-1b [KO:K02353]
569863  dvl1a; segment polarity protein dishevelled homolog DVL-1 isoform X4 [KO:K02353]
80972  dvl3a; segment polarity protein dishevelled homolog DVL-3a [KO:K02353]
100149082  dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
30719  gbp; glycogen synthase kinase binding protein [KO:K03096]
30488  csnk2a2a; casein kinase 2, alpha prime polypeptide a [KO:K03097] [EC:2.7.11.1]
30502  csnk2a1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
415254  zgc:86598; STKc_CK2_alpha domain-containing protein [KO:K03097] [EC:2.7.11.1]
556379  csnk2a2b; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
100535532  csnk2a4; casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
30428  csnk2b; casein kinase II subunit beta [KO:K03115]
751108  nkd1; protein naked cuticle homolog 1 [KO:K03213]
794221  nkd2b; protein naked cuticle homolog 2-like [KO:K03213]
100049175  nkd2a; protein naked cuticle homolog 2 [KO:K03213]
100006754  cxxc4; CXXC-type zinc finger protein 4 [KO:K03344]
100330136  CXXC-type zinc finger protein 4-like [KO:K03344]
556400  senp2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
30654  gsk3ba; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
557882  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b [KO:K03083] [EC:2.7.11.26]
30265  ctnnb1; catenin beta-1 [KO:K02105]
324004  ctnnb2; catenin, beta 2 [KO:K02105]
57931  axin1; axin-1 [KO:K02157]
58080  axin2; axin-2 [KO:K04385]
565771  apc2; adenomatous polyposis coli protein 2 [KO:K02085]
386762  apc; adenomatous polyposis coli protein [KO:K02085]
192307  csnk1a1; casein kinase I isoform alpha [KO:K08957] [EC:2.7.11.1]
497649  tcf7; transcription factor 7 [KO:K02620]
30523  tcf7l1a; transcription factor 7-like 1-A [KO:K04490]
30556  tcf7l1b; transcription factor 7-like 1-B [KO:K04490]
30510  tcf7l2; transcription factor 7-like 2 [KO:K04491]
30701  lef1; lymphoid enhancer-binding factor 1 [KO:K04492]
100005471  lzts2b; leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
570926  lzts2a; leucine zipper putative tumor suppressor 2a [KO:K26471]
58117  ctnnbip1; beta-catenin-interacting protein 1 [KO:K04493]
326875  cby1; protein chibby homolog 1 [KO:K23402]
568214  chd8; chromodomain-helicase-DNA-binding protein 8 [KO:K04494] [EC:5.6.2.-]
100537329  mcc; colorectal mutant cancer protein isoform X1 [KO:K26734]
564155  ccar2; cell cycle and apoptosis regulator protein 2 isoform X1 [KO:K25816]
797132  sirt1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
30544  sox17; transcription factor SOX-17 [KO:K04495]
65229  ctbp1; C-terminal-binding protein 1 [KO:K04496] [EC:1.1.1.428]
678649  zgc:136929; C-terminal-binding protein 1 [KO:K04496] [EC:1.1.1.428]
65230  ctbp2a; C-terminal-binding protein 2a isoform 1 [KO:K04496] [EC:1.1.1.428]
548605  ctbp2l; C-terminal binding protein 2, like [KO:K04496] [EC:1.1.1.428]
30206  tle3a; transducin-like enhancer protein 3-A isoform 1 [KO:K04497]
100007463  tle3b; transducin-like enhancer protein 3-B [KO:K04497]
565013  tle2a; transducin-like enhancer protein 2a [KO:K04497]
564019  si:dkey-42p8.3; transducin-like enhancer protein 4 isoform X2 [KO:K04497]
558069  ctnnd2b; catenin delta-2b isoform 2 [KO:K23491]
368485  ctnnd2a; catenin delta-2 isoform X1 [KO:K23491]
559273  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
565612  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
566841  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
567111  crebbpb; CREB binding protein b [KO:K04498] [EC:2.3.1.48]
317679  ruvbl1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
560317  smad10a; uncharacterized protein LOC560317 isoform 2 [KO:K04501]
559111  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
100151181  si:dkey-239n17.4; mothers against decapentaplegic homolog 4-like [KO:K04501]
794669  gb:cr929477; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
326283  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
58092  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
553788  map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
563460  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
405892  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
393141  mycb; transcriptional regulator Myc-B [KO:K04377]
30686  myca; transcriptional regulator Myc-A [KO:K04377]
335916  jun; transcription factor AP-1 [KO:K04448]
564241  fosl1a; fos-related antigen 1a [KO:K04502]
30222  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
799608  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
565038  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
449996  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
560713  ccn4a; cellular communication network factor 4a precursor [KO:K22471]
792714  ccn4b; cellular communication network factor 4b precursor [KO:K22471]
30754  ppardb; peroxisome proliferator-activated receptor delta b [KO:K04504]
30750  pparda; peroxisome proliferator-activated receptor delta [KO:K04504]
30221  psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
393998  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
445076  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
563147  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
564064  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
30590  tp53; cellular tumor antigen p53 isoform 2 [KO:K04451]
80955  siah1; E3 ubiquitin-protein ligase Siah1 [KO:K04506] [EC:2.3.2.27]
405823  cacybp; calcyclin-binding protein [KO:K04507]
393716  skp1; S-phase kinase-associated protein 1 [KO:K03094]
560294  tbl1x; F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
393581  tbl1xr1b; F-box-like/WD repeat-containing protein TBL1XR1b [KO:K04508]
553608  tbl1xr1a; F-box-like/WD repeat-containing protein TBL1XR1a [KO:K04508]
334373  fbxw11a; F-box and WD repeat domain-containing 11-A [KO:K03362]
406825  fbxw11b; F-box and WD repeat domain-containing 11-B [KO:K03362]
323883  cul1a; cullin-1a [KO:K03347]
406816  cul1b; cullin-1b [KO:K03347]
449846  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
118437  gpc4; glypican-4 precursor [KO:K08110]
568282  ror1; inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122] [EC:2.7.10.1]
561183  ror2; tyrosine-protein kinase transmembrane receptor ROR2 [KO:K05123] [EC:2.7.10.1]
558502  ryk; tyrosine-protein kinase RYK precursor [KO:K05128] [EC:2.7.10.1]
245949  vangl2; vang-like protein 2 [KO:K04510]
403076  vangl1; vang-like protein 1 [KO:K04510]
368249  prickle1a; prickle-like protein 1a [KO:K04511]
368250  prickle2b; prickle-like protein 2b [KO:K04511]
556148  prickle1b; prickle-like protein 1b [KO:K04511]
570116  prickle3; prickle-like protein 2 isoform X2 [KO:K04511]
777736  prickle2a; uncharacterized protein LOC777736 [KO:K04511]
245946  invs; inversin [KO:K19626]
557451  daam1a; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
560060  daam1b; disheveled-associated activator of morphogenesis 1b [KO:K04512]
798465  daam2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
406411  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
406659  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
436718  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
751630  zgc:153713; RhoA_like domain-containing protein [KO:K04513]
100006041  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
317747  rock2a; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
321070  rock2b; rho-associated protein kinase 2b [KO:K17388] [EC:2.7.11.1]
327204  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
792699  rac1l; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
562838  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
100537765  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
415151  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
437027  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
795167  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
569698  mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
562720  mapk8a; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
65236  mapk8b; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
100149273  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
100001532  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100537538  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
569376  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100149080  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
407700  plcb4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
436815  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain [KO:K04515] [EC:2.7.11.17]
445208  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform 1 [KO:K04515] [EC:2.7.11.17]
550436  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2 [KO:K04515] [EC:2.7.11.17]
562064  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 [KO:K04515] [EC:2.7.11.17]
793359  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X26 [KO:K04515] [EC:2.7.11.17]
798222  camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4 [KO:K04515] [EC:2.7.11.17]
791855  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 [KO:K04515] [EC:2.7.11.17]
794574  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
557926  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a [KO:K04348] [EC:3.1.3.16]
550554  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
565241  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b [KO:K04348] [EC:3.1.3.16]
447814  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
564337  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
497384  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
100333967  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100006675  prkcba; protein kinase C, beta a [KO:K19662] [EC:2.7.11.13]
393953  prkcbb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100003514  prkcg; protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
568315  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
100333254  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
571865  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
561772  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
566869  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3-like isoform X2 [KO:K17333]
561682  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
dre04010  MAPK signaling pathway
dre04110  Cell cycle
dre04115  p53 signaling pathway
dre04120  Ubiquitin mediated proteolysis
dre04350  TGF-beta signaling pathway
dre04510  Focal adhesion
dre04520  Adherens junction
KO pathway
ko04310   
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