Entry Name Wnt signaling pathway - Danio rerio (zebrafish)
Description Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Danio rerio (zebrafish) [GN:
dre ]
Gene 100003877 lrp6; low-density lipoprotein receptor-related protein 6 precursor [KO:K03068 ]
100005471 lzts2b; leucine zipper putative tumor suppressor 2 homolog [KO:K26471 ]
100149082 dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
100151181 smad10b; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501 ]
100330212 lgr6; leucine-rich repeat-containing G-protein coupled receptor 6 precursor [KO:K08399 ]
100333254 nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
117510 sfrp5; secreted frizzled-related protein 5 precursor [KO:K02222 ]
30119 frzb; secreted frizzled-related protein 3 precursor [KO:K25481 ]
30197 dkk1b; dickkopf-related protein 1b precursor [KO:K02165 ]
30206 tle3a; transducin-like enhancer protein 3-A isoform 1 [KO:K04497 ]
30428 csnk2b; casein kinase II subunit beta [KO:K03115 ]
30476 wif1; wnt inhibitory factor 1 precursor [KO:K01691 ]
30510 tcf7l2; transcription factor 7-like 2 [KO:K04491 ]
30523 tcf7l1a; transcription factor 7-like 1-A [KO:K04490 ]
30556 tcf7l1b; transcription factor 7-like 1-B [KO:K04490 ]
30590 tp53; cellular tumor antigen p53 isoform 2 [KO:K04451 ]
30686 myca; transcriptional regulator Myc-A [KO:K04377 ]
30701 lef1; lymphoid enhancer-binding factor 1 [KO:K04492 ]
30719 gbp; glycogen synthase kinase binding protein [KO:K03096 ]
30750 pparda; peroxisome proliferator-activated receptor delta [KO:K04504 ]
30754 ppardb; peroxisome proliferator-activated receptor delta b [KO:K04504 ]
323630 dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
326283 smad3b; mothers against decapentaplegic homolog 3b [KO:K23605 ]
327204 rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
334373 fbxw11a; F-box and WD repeat domain-containing 11-A [KO:K03362 ]
359837 wnt2ba; wingless-type MMTV integration site family, member 2Ba [KO:K00182 ]
393581 tbl1xr1b; F-box-like/WD repeat-containing protein TBL1XR1b [KO:K04508 ]
393716 skp1; S-phase kinase-associated protein 1 [KO:K03094 ]
402843 sfrp1a; secreted frizzled-related protein 1a precursor [KO:K02166 ]
406411 rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513 ]
406659 rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513 ]
406825 fbxw11b; F-box and WD repeat domain-containing 11-B [KO:K03362 ]
407700 plcb4b; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858 ] [EC:3.1.4.11 ]
415151 rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
431736 bambib; BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b precursor [KO:K10162 ]
436718 rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513 ]
436815 camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain [KO:K04515 ] [EC:2.7.11.17 ]
436917 notum1b; inactive palmitoleoyl-protein carboxylesterase notum1b precursor [KO:K19882 ] [EC:3.1.1.98 ]
437027 rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861 ]
445208 camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform 1 [KO:K04515 ] [EC:2.7.11.17 ]
447800 serpinf1; pigment epithelium-derived factor precursor [KO:K19614 ]
550436 camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2 [KO:K04515 ] [EC:2.7.11.17 ]
550554 ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348 ] [EC:3.1.3.16 ]
553608 tbl1xr1a; F-box-like/WD repeat-containing protein TBL1XR1a [KO:K04508 ]
556087 wnt2bb; wingless-type MMTV integration site family, member 2Bb [KO:K00182 ]
557451 daam1a; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512 ]
557926 ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a [KO:K04348 ] [EC:3.1.3.16 ]
558825 lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 precursor [KO:K04309 ]
559111 smad4a; mothers against decapentaplegic homolog 4a [KO:K04501 ]
560032 dvl1b; segment polarity protein dishevelled homolog DVL-1b [KO:K02353 ]
560060 daam1b; disheveled-associated activator of morphogenesis 1b [KO:K04512 ]
560294 tbl1x; F-box-like/WD repeat-containing protein TBL1X [KO:K04508 ]
560317 smad10a; uncharacterized protein LOC560317 isoform 2 [KO:K04501 ]
560713 ccn4a; cellular communication network factor 4a precursor [KO:K22471 ]
561682 nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
561772 nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
562064 camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 [KO:K04515 ] [EC:2.7.11.17 ]
562838 rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392 ]
564019 tle2b; transducin-like enhancer protein 4 isoform X2 [KO:K04497 ]
564064 prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345 ] [EC:2.7.11.11 ]
564155 ccar2; cell cycle and apoptosis regulator protein 2 isoform X1 [KO:K25816 ]
565013 tle2a; transducin-like enhancer protein 2a [KO:K04497 ]
565241 ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b [KO:K04348 ] [EC:3.1.3.16 ]
565714 wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572 ]
565771 apc2; adenomatous polyposis coli protein 2 [KO:K02085 ]
566869 nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333 ]
566878 sfrp2; secreted frizzled-related protein 2 precursor [KO:K02176 ]
568214 chd8; chromodomain-helicase-DNA-binding protein 8 [KO:K04494 ] [EC:5.6.2.-]
568315 nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
568518 lrp5; low-density lipoprotein receptor-related protein 5 isoform 1 precursor [KO:K03068 ]
569376 plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
569863 dvl1a; segment polarity protein dishevelled homolog DVL-1 isoform X4 [KO:K02353 ]
570116 prickle3; prickle planar cell polarity protein 3 isoform X2 [KO:K04511 ]
570926 lzts2a; leucine zipper putative tumor suppressor 2a [KO:K26471 ]
58092 smad3a; mothers against decapentaplegic homolog 3a [KO:K23605 ]
58117 ctnnbip1; beta-catenin-interacting protein 1 [KO:K04493 ]
751630 zgc:153713; RhoA_like domain-containing protein [KO:K04513 ]
777736 prickle2a; uncharacterized protein LOC777736 [KO:K04511 ]
791454 dand5; DAN domain family member 5 precursor [KO:K01645 ]
791855 camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 [KO:K04515 ] [EC:2.7.11.17 ]
791993 wnt4b; wingless-type MMTV integration site family, member 4b precursor [KO:K00408 ]
792404 dkk2; dickkopf-related protein 2 precursor [KO:K02165 ]
792699 rac1l; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
792714 ccn4b; cellular communication network factor 4b precursor [KO:K22471 ]
793359 camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X25 [KO:K04515 ] [EC:2.7.11.17 ]
794221 nkd2b; protein naked cuticle homolog 2-like [KO:K03213 ]
794574 ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
794669 smad4b; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501 ]
795167 rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861 ]
798465 daam2; disheveled-associated activator of morphogenesis 2 [KO:K04512 ]
798564 sfrp1b; secreted frizzled-related protein 1b precursor [KO:K02166 ]
799377 dkk1a; dickkopf WNT signaling pathway inhibitor 1a precursor [KO:K02165 ]
80972 dvl3a; segment polarity protein dishevelled homolog DVL-3a [KO:K02353 ]
83496 bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a precursor [KO:K10162 ]
Compound Reference Authors Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title Beta-catenin and Tcfs in mammary development and cancer.
Journal Reference Authors Yang Y.
Title Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal Reference Authors Kalderon D.
Title Similarities between the Hedgehog and Wnt signaling pathways.
Journal Reference Authors Nusse R.
Title Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal Reference Authors Jope RS, Johnson GV.
Title The glamour and gloom of glycogen synthase kinase-3.
Journal Reference Authors Veeman MT, Axelrod JD, Moon RT.
Title A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal Reference Authors Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal Reference Authors Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title The way Wnt works: Components and mechanism.
Journal Reference Authors Carethers JM
Title Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal Reference Authors Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal Reference Authors Niehrs C
Title The complex world of WNT receptor signalling.
Journal Reference Authors Abou Ziki MD, Mani A
Title Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal Reference Authors He Y, Ki H, Kim H, Kim K
Title delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal Reference Authors Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal Reference Authors Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal Related KO pathway
