KEGG   PATHWAY: dre04330
Entry
dre04330                    Pathway                                
Name
Notch signaling pathway - Danio rerio (zebrafish)
Description
The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.
Class
Environmental Information Processing; Signal transduction
Pathway map
dre04330  Notch signaling pathway
dre04330

Other DBs
GO: 0007219
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
100007463  tle3b; transducin-like enhancer protein 3-B [KO:K04497]
100037355  dtx4b; E3 ubiquitin-protein ligase DTX4 [KO:K06058] [EC:2.3.2.27]
100144568  si:dkey-3h3.3; uncharacterized protein LOC100144568 [KO:K06058] [EC:2.3.2.27]
100148329  her4.2; hairy-related 4, tandem duplicate 2 [KO:K06055]
100149066  her4.4; hairy-related 4, tandem duplicate 4 [KO:K06055]
100149082  dvl3b; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100149863  her4.1; hairy-related 4, tandem duplicate 1 [KO:K06055]
100329328  maml2; mastermind-like protein 2 [KO:K06061]
100330031  itchb; itchy E3 ubiquitin protein ligase B [KO:K05632] [EC:2.3.2.26]
100331274  itcha; itchy E3 ubiquitin protein ligase A [KO:K05632] [EC:2.3.2.26]
100534909  her15.1; hairy and enhancer of split-related 15, tandem duplicate 1 [KO:K06055]
101885597  dtx1; E3 ubiquitin-protein ligase DTX1 [KO:K06058] [EC:2.3.2.27]
101886283  maml3; mastermind-like protein 3 [KO:K06061]
140421  jag1a; protein jagged-1a precursor [KO:K06052]
140422  jag2b; protein jagged-2b precursor [KO:K21635]
140423  jag1b; protein jagged-1b precursor [KO:K06052]
140613  her9; hairy-related 9 [KO:K06054]
192302  hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
30120  dlc; delta-like protein C precursor [KO:K06051]
30131  dla; delta-like protein A precursor [KO:K06051]
30138  dldH; delta-like protein D precursor [KO:K06051]
30141  dlb; delta-like protein B precursor [KO:K06051]
30158  lfnG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe precursor [KO:K05948] [EC:2.4.1.222]
30206  tle3a; transducin-like enhancer protein 3-A isoform 2 [KO:K04497]
30221  psen1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
30288  her6; hairy-related 6 [KO:K06054]
30300  her2; hairy-related 2 [KO:K06055]
30301  her4.5; hairy-related 4, tandem duplicate 5 [KO:K06055]
30718  notch1a; neurogenic locus notch homolog protein 1 precursor [KO:K02599]
321852  snw1; SNW domain-containing protein 1 [KO:K06063]
322667  [KO:K25100]
323630  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
324142  adam17a; disintegrin and metalloproteinase domain-containing protein 17a precursor [KO:K06059] [EC:3.4.24.86]
335134  heyL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
353224  nrarpa; notch-regulated ankyrin repeat-containing protein A [KO:K26480]
353225  nrarpb; notch-regulated ankyrin repeat-containing protein B [KO:K26480]
359836  her15.2; hairy and enhancer of split-related 15, tandem duplicate 2 [KO:K06055]
386772  rbpja; recombination signal binding protein for immunoglobulin kappa J region A [KO:K06053]
386808  aph1b; gamma-secretase subunit Aph-1b [KO:K06172]
393500  dtx3; probable E3 ubiquitin-protein ligase DTX3 [KO:K06058] [EC:2.3.2.27]
402810  psenen; gamma-secretase subunit PEN-2 [KO:K06170]
402914  her12; hairy-related 12 [KO:K06055]
414848  rfnG; beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
493633  mfnG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
494449  ncstn; nicastrin precursor [KO:K06171]
497616  numbl; numb-like protein [KO:K06057]
503870  rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
503940  speN; msx2-interacting protein isoform X1 [KO:K25100]
548605  ctbp2l; C-terminal binding protein 2, like isoform X1 [KO:K04496] [EC:1.1.1.428]
553421  cirsr; corepressor interacting with RBPJ 1 [KO:K06066]
555517  kat2a; histone acetyltransferase KAT2A [KO:K06062] [EC:2.3.1.48]
557340  atxn1a; ataxin-1a [KO:K23616]
559273  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
559336  zgc:114200; Gamma-secretase subunit Aph-1b-like [KO:K06172]
560032  dvl1b; segment polarity protein dishevelled homolog DVL-1b [KO:K02353]
560657  adam17b; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
561503  ncor2; nuclear receptor corepressor 2 isoform X2 [KO:K06065]
563306  rbpjb; recombination signal binding protein for immunoglobulin kappa J region B [KO:K06053]
563920  dll4; delta-like protein 4 precursor [KO:K06051]
563942  kat2b; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
564019  tle2b; transducin-like enhancer protein 4 isoform X2 [KO:K04497]
565013  tle2a; transducin-like enhancer protein 2A [KO:K04497]
565612  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
565841  atxn1b; ataxin-1 [KO:K23616]
566455  jag2a; protein jagged-2 isoform X2 [KO:K21635]
566841  [KO:K04498] [EC:2.3.1.48]
567111  [KO:K04498] [EC:2.3.1.48]
567335  maml1; mastermind-like protein 1 isoform X1 [KO:K06061]
568626  dtx2; probable E3 ubiquitin-protein ligase DTX2 [KO:K06058] [EC:2.3.2.27]
569863  dvl1a; segment polarity protein dishevelled homolog DVL-1 isoform X5 [KO:K02353]
570481  dtx4a; E3 ubiquitin-protein ligase DTX4a [KO:K06058] [EC:2.3.2.27]
571706  [KO:K23616]
58008  hey1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
58026  psen2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
58065  notch2; neurogenic locus notch homolog protein 2 precursor [KO:K20994]
58066  notch3; neurogenic locus notch homolog protein 3 precursor [KO:K20995]
58146  hey2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
65229  ctbp1l; C-terminal-binding protein 1 [KO:K04496] [EC:1.1.1.428]
65230  ctbp2a; C-terminal-binding protein 2a isoform 1 [KO:K04496] [EC:1.1.1.428]
678649  ctbp1; C-terminal-binding protein 1 isoform X2 [KO:K04496] [EC:1.1.1.428]
692064  numB; protein numb homolog [KO:K06057]
792198  her4.3; hairy-related 4, tandem duplicate 3 [KO:K06055]
793927  atxn1l; ataxin-1-like [KO:K23616]
794892  notch1b; neurogenic locus notch homolog protein 1b precursor [KO:K02599]
80972  dvl3a; segment polarity protein dishevelled homolog DVL-3a [KO:K02353]
Compound
C22528  Notch intracellular domain
Reference
PMID:15288257
  Authors
Hansson EM, Lendahl U, Chapman G.
  Title
Notch signaling in development and disease.
  Journal
Semin Cancer Biol 14:320-8 (2004)
DOI:10.1016/j.semcancer.2004.04.011
Reference
PMID:15300010
  Authors
Callahan R, Egan SE.
  Title
Notch signaling in mammary development and oncogenesis.
  Journal
J Mammary Gland Biol Neoplasia 9:145-63 (2004)
DOI:10.1023/B:JOMG.0000037159.63644.81
Reference
PMID:15288258
  Authors
Zweidler-McKay PA, Pear WS.
  Title
Notch and T cell malignancy.
  Journal
Semin Cancer Biol 14:329-40 (2004)
DOI:10.1016/j.semcancer.2004.04.012
Reference
PMID:15288260
  Authors
Wu L, Griffin JD.
  Title
Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis.
  Journal
Semin Cancer Biol 14:348-56 (2004)
DOI:10.1016/j.semcancer.2004.04.014
Reference
PMID:15585829
  Authors
Tsukumo S, Yasutomo K.
  Title
Notch governing mature T cell differentiation.
  Journal
J Immunol 173:7109-13 (2004)
DOI:10.4049/jimmunol.173.12.7109
Reference
PMID:12464310
  Authors
Haltiwanger RS.
  Title
Regulation of signal transduction pathways in development by glycosylation.
  Journal
Curr Opin Struct Biol 12:593-8 (2002)
DOI:10.1016/S0959-440X(02)00371-8
Reference
PMID:15272268
  Authors
Koo EH, Kopan R.
  Title
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.
  Journal
Nat Med 10 Suppl:S26-33 (2004)
DOI:10.1038/nm1065
Reference
PMID:11896183
  Authors
Okano H, Imai T, Okabe M.
  Title
Musashi: a translational regulator of cell fate.
  Journal
J Cell Sci 115:1355-9 (2002)
Reference
PMID:12417415
  Authors
Haltiwanger RS, Stanley P.
  Title
Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferase.
  Journal
Biochim Biophys Acta 1573:328-35 (2002)
DOI:10.1016/S0304-4165(02)00400-2
Reference
PMID:12015972
  Authors
Das G, Reynolds-Kenneally J, Mlodzik M.
  Title
The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye.
  Journal
Dev Cell 2:655-66 (2002)
DOI:10.1016/S1534-5807(02)00147-8
Reference
PMID:10028969
  Authors
Cooper MT, Bray SJ.
  Title
Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye.
  Journal
Nature 397:526-30 (1999)
DOI:10.1038/17395
Reference
PMID:12681948
  Authors
Tanigaki K, Kuroda K, Han H, Honjo T.
  Title
Regulation of B cell development by Notch/RBP-J signaling.
  Journal
Semin Immunol 15:113-9 (2003)
DOI:10.1016/S1044-5323(03)00008-3
Reference
PMID:28487372
  Authors
Tabaja N, Yuan Z, Oswald F, Kovall RA
  Title
Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes.
  Journal
J Biol Chem 292:10549-10563 (2017)
DOI:10.1074/jbc.M117.791707
Related
pathway
dre04010  MAPK signaling pathway
KO pathway
ko04330   

DBGET integrated database retrieval system