KEGG   PATHWAY: dro04971
Entry
dro04971                    Pathway                                
Name
Gastric acid secretion - Desmodus rotundus (common vampire bat)
Description
Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetycholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+,K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H+ secretion into the stomach lumen.
Class
Organismal Systems; Digestive system
Pathway map
dro04971  Gastric acid secretion
dro04971

Other DBs
GO: 0001696
Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112296671  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
112296774  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
112296778  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
112297289  EZR; LOW QUALITY PROTEIN: ezrin [KO:K08007]
112297606  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
112297750  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
112297939  CALM2; calmodulin-2 [KO:K02183]
112298360  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
112298654  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
112298712  ACTG1; actin, cytoplasmic 2 [KO:K05692]
112298732  GAST; gastrin [KO:K13768]
112299258  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
112299615  CALML6; calmodulin-like protein 6 [KO:K02183]
112300359  [KO:K04634]
112300407  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
112300586  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
112301078  [KO:K02183]
112301115  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
112301523  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112301899  KCNJ1; ATP-sensitive inward rectifier potassium channel 1 isoform X1 [KO:K04995]
112302101  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
112303430  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
112303707  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
112303826  [KO:K04632]
112303827  [KO:K04632]
112304118  KCNJ15; ATP-sensitive inward rectifier potassium channel 15 [KO:K05008]
112304122  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
112304255  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
112304830  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
112305250  SST; somatostatin [KO:K05237]
112305463  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
112305954  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
112306844  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
112306861  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
112308281  SLC4A2; anion exchange protein 2 isoform X1 [KO:K13855]
112308526  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
112308768  KCNE2; potassium voltage-gated channel subfamily E member 2 [KO:K04896]
112309395  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
112309625  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
112309828  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
112310823  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
112311250  CALM1; calmodulin-1 [KO:K02183]
112311437  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
112311614  KCNK10; potassium channel subfamily K member 10 isoform X1 [KO:K04920]
112311702  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
112312435  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
112312797  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
112312926  CALM3; calmodulin-3 [KO:K02183]
112313520  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
112313776  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
112314761  KCNJ10; ATP-sensitive inward rectifier potassium channel 10 [KO:K05003]
112315217  SLC9A4; sodium/hydrogen exchanger 4 [KO:K13961]
112315487  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
112315545  SLC26A7; anion exchange transporter [KO:K13962]
112315807  [KO:K01539] [EC:7.2.2.13]
112316283  KCNJ2; inward rectifier potassium channel 2 [KO:K04996]
112316426  KCNJ16; inward rectifier potassium channel 16 [KO:K05009]
112316515  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112316572  SSTR2; somatostatin receptor type 2 [KO:K04218]
112317151  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
112317429  KCNQ1; potassium voltage-gated channel subfamily KQT member 1 [KO:K04926]
112317734  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
112318382  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
112318673  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
112319437  ACTB; actin, cytoplasmic 1 [KO:K05692]
112319441  HRH2; histamine H2 receptor [KO:K04150]
112319561  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
112320122  ATP4A; potassium-transporting ATPase alpha chain 1 [KO:K01542] [EC:7.2.2.19]
112320186  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
112320488  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
112320512  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
112320764  CA2; carbonic anhydrase 2 [KO:K18245] [EC:4.2.1.1]
112321008  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112321120  [KO:K02183]
112321262  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112321536  ATP4B; potassium-transporting ATPase subunit beta [KO:K01543] [EC:7.2.2.19]
112322988  CALML3; calmodulin-like protein 3 [KO:K02183]
Compound
C00001  H2O
C00011  CO2
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00288  HCO3-
C00388  Histamine
C00575  3',5'-Cyclic AMP
C00698  Cl-
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01353  Carbonic acid
C01996  Acetylcholine
Reference
PMID:18474247
  Authors
Schubert ML, Peura DA
  Title
Control of gastric acid secretion in health and disease.
  Journal
Gastroenterology 134:1842-60 (2008)
DOI:10.1053/j.gastro.2008.05.021
Reference
PMID:9307437
  Authors
Urushidani T, Forte JG
  Title
Signal transduction and activation of acid secretion in the parietal cell.
  Journal
J Membr Biol 159:99-111 (1997)
DOI:10.1007/s002329900274
Reference
PMID:12500969
  Authors
Yao X, Forte JG
  Title
Cell biology of acid secretion by the parietal cell.
  Journal
Annu Rev Physiol 65:103-31 (2003)
DOI:10.1146/annurev.physiol.65.072302.114200
Reference
PMID:17928547
  Authors
Heitzmann D, Warth R
  Title
No potassium, no acid: K+ channels and gastric acid secretion.
  Journal
Physiology (Bethesda) 22:335-41 (2007)
DOI:10.1152/physiol.00016.2007
Reference
PMID:19889964
  Authors
Kopic S, Murek M, Geibel JP
  Title
Revisiting the parietal cell.
  Journal
Am J Physiol Cell Physiol 298:C1-C10 (2010)
DOI:10.1152/ajpcell.00478.2009
Reference
PMID:15703676
  Authors
Schubert ML
  Title
Gastric secretion.
  Journal
Curr Opin Gastroenterol 20:519-25 (2004)
DOI:10.1097/00001574-200411000-00003
Reference
PMID:16391411
  Authors
Konturek SJ, Konturek PC, Brzozowski T, Konturek JW, Pawlik WW
  Title
From nerves and hormones to bacteria in the stomach; Nobel prize for achievements in gastrology during last century.
  Journal
J Physiol Pharmacol 56:507-30 (2005)
Reference
PMID:20148676
  Authors
Forte JG, Zhu L
  Title
Apical recycling of the gastric parietal cell H,K-ATPase.
  Journal
Annu Rev Physiol 72:273-96 (2010)
DOI:10.1146/annurev-physiol-021909-135744
Reference
PMID:18061403
  Authors
Szaszak M, Christian F, Rosenthal W, Klussmann E
  Title
Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
  Journal
Cell Signal 20:590-601 (2008)
DOI:10.1016/j.cellsig.2007.10.020
Reference
PMID:18626068
  Authors
Heitzmann D, Warth R
  Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
  Journal
Physiol Rev 88:1119-82 (2008)
DOI:10.1152/physrev.00020.2007
Reference
PMID:15579540
  Authors
Heitzmann D, Grahammer F, von Hahn T, Schmitt-Graff A, Romeo E, Nitschke R, Gerlach U, Lang HJ, Verrey F, Barhanin J, Warth R
  Title
Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells.
  Journal
J Physiol 561:547-57 (2004)
DOI:10.1113/jphysiol.2004.075168
Reference
PMID:20331540
  Authors
Seidler U, Song P, Xiao F, Riederer B, Bachmann O, Chen M
  Title
Recent advances in the molecular and functional characterization of acid/base and electrolyte transporters in the basolateral membranes of gastric and duodenal epithelial cells.
  Journal
Acta Physiol (Oxf) 201:3-20 (2011)
DOI:10.1111/j.1748-1716.2010.02107.x
Related
pathway
dro04020  Calcium signaling pathway
dro04530  Tight junction
dro04974  Protein digestion and absorption
KO pathway
ko04971   

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