KEGG   PATHWAY: dro04530
Entry
dro04530                    Pathway                                
Name
Tight junction - Desmodus rotundus (common vampire bat)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
dro04530  Tight junction
dro04530

Other DBs
GO: 0005923
Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112296369  ARHGEF18; rho guanine nucleotide exchange factor 18 [KO:K21066]
112296379  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112296885  CLDN2; claudin-2 [KO:K06087]
112297079  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
112297137  CLDN20; claudin-20 [KO:K06087]
112297167  AFDN; afadin isoform X1 [KO:K05702]
112297289  EZR; LOW QUALITY PROTEIN: ezrin [KO:K08007]
112297324  BVES; blood vessel epicardial substance [KO:K21108]
112297718  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
112297870  ACTR2; actin-related protein 2 [KO:K17260]
112297902  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
112297947  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
112298480  CLDN6; claudin-6 [KO:K06087]
112298481  CLDN9; claudin-9 [KO:K06087]
112298631  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
112298650  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
112298712  ACTG1; actin, cytoplasmic 2 [KO:K05692]
112299039  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
112299195  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
112299540  CLDN19; claudin-19 [KO:K06087]
112299985  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
112300009  [KO:K06099]
112300030  [KO:K06099]
112300117  DLG3; disks large homolog 3 [KO:K21098]
112300123  MSN; moesin [KO:K05763]
112300238  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
112300407  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
112300602  MARVELD3; MARVEL domain-containing protein 3 [KO:K21099]
112300669  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
112300910  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
112300966  CLDN1; claudin-1 [KO:K06087]
112301160  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
112301206  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
112301228  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
112301523  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112301608  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
112301743  [KO:K07374]
112301806  [KO:K07374]
112301928  CLDN5; claudin-5 [KO:K06087]
112301929  JAM3; junctional adhesion molecule C [KO:K06785]
112302238  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
112302860  MPDZ; multiple PDZ domain protein [KO:K06095]
112303160  [KO:K03456]
112303838  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
112303920  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
112304019  CLDN17; claudin-17 [KO:K06087]
112304029  CLDN8; claudin-8 [KO:K06087]
112304037  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
112304110  CLDN14; claudin-14 [KO:K06087]
112304120  PCNA; proliferating cell nuclear antigen [KO:K04802]
112304180  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
112304437  EPB41L4B; band 4.1-like protein 4B [KO:K21111]
112304482  JAM2; junctional adhesion molecule B [KO:K06735]
112304674  ARHGAP17; rho GTPase-activating protein 17 [KO:K20638]
112304835  CLDN11; claudin-11 [KO:K06087]
112305131  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
112305194  RAB8A; ras-related protein Rab-8A [KO:K07901]
112305238  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
112305558  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112305670  RUNX1; runt-related transcription factor 1 [KO:K08367]
112305974  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
112306071  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
112306137  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
112306229  [KO:K05754]
112306529  [KO:K05754]
112306681  CLDN23; LOW QUALITY PROTEIN: claudin-23 [KO:K06087]
112306709  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112306760  CLDN22; claudin-22 [KO:K06087]
112306761  [KO:K06087]
112307394  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
112307557  [KO:K04513]
112307737  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
112307747  [KO:K07374]
112307817  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
112307844  [KO:K06448]
112307926  [KO:K07374]
112307990  [KO:K06448]
112308059  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
112308245  AMOT; angiomotin [KO:K16819]
112308274  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
112308276  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
112308485  LLGL1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
112308639  CLDN7; claudin-7 [KO:K06087]
112308727  MYH10; myosin-10 isoform X1 [KO:K10352]
112309168  PATJ; inaD-like protein isoform X1 [KO:K06092]
112309395  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
112309492  RHOA; transforming protein RhoA [KO:K04513]
112309899  AMOTL2; angiomotin-like protein 2 [KO:K06104]
112309977  CLDN18; claudin-18 isoform X1 [KO:K06087]
112310058  MYH14; myosin-14 isoform X1 [KO:K10352]
112310383  NF2; merlin isoform X1 [KO:K16684]
112310679  [KO:K10351]
112310708  [KO:K10351]
112310730  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
112310764  RAP2C; ras-related protein Rap-2c [KO:K07839]
112310846  ARPC3; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 3 [KO:K05756]
112311182  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
112311239  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
112311505  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
112311593  RAB8B; ras-related protein Rab-8B [KO:K07902]
112311601  TUBA8; tubulin alpha-8 chain [KO:K07374]
112311893  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
112312307  GATA4; transcription factor GATA-4 [KO:K09183]
112312321  CLDN10; claudin-10 isoform X1 [KO:K06087]
112312369  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
112312378  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
112312573  CRB3; protein crumbs homolog 3 [KO:K06090]
112312596  TJP3; tight junction protein ZO-3 [KO:K06097]
112312818  SYMPK; symplekin isoform X1 [KO:K06100]
112312938  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
112313015  ACTR3; actin-related protein 3 [KO:K18584]
112313306  CLDN34; claudin-34 [KO:K06087]
112313714  RAP1A; ras-related protein Rap-1A [KO:K04353]
112314173  CLDN25; putative claudin-25 [KO:K06087]
112314186  RDX; radixin isoform X1 [KO:K05762]
112314247  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
112314287  RAB13; ras-related protein Rab-13 [KO:K06109]
112314641  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
112314642  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
112314669  [KO:K06448]
112314690  [KO:K06448]
112314877  CLDN3; claudin-3 [KO:K06087]
112314881  CLDN4; claudin-4 [KO:K06087]
112314905  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
112314915  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
112315043  MYH11; myosin-11 [KO:K10352]
112315055  CLDN15; claudin-15 [KO:K06087]
112315269  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
112315649  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
112316026  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
112316195  CGN; cingulin [KO:K06102]
112316215  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
112316681  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
112317066  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
112317199  CTTN; src substrate cortactin isoform X1 [KO:K06106]
112317273  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112317360  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
112317568  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
112317701  ITGB1; integrin beta-1 [KO:K05719]
112317737  PARD3; partitioning defective 3 homolog [KO:K04237]
112317841  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112318080  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
112318081  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
112318375  [KO:K07374]
112318467  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
112318528  YBX3; Y-box-binding protein 3 [KO:K06099]
112318638  [KO:K07374]
112318639  TUBA1B; tubulin alpha-1B chain [KO:K07374]
112318961  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
112318962  MYL6B; myosin light chain 6B [KO:K12751]
112319119  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
112319437  ACTB; actin, cytoplasmic 1 [KO:K05692]
112319536  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
112319549  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112319626  MICALL2; MICAL-like protein 2 [KO:K21068]
112319716  SYNPO; synaptopodin [KO:K21112]
112319875  CLDN12; claudin-12 [KO:K06087]
112320200  ACTN4; alpha-actinin-4 [KO:K05699]
112320513  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
112320555  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
112321073  OCLN; occludin isoform X1 [KO:K06088]
112321079  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
112321095  MARVELD2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
112321272  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
112321857  MYH9; myosin-9 [KO:K10352]
112322501  WAS; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein [KO:K05747]
112322715  [KO:K12757]
112322716  [KO:K12757]
112322904  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
112322916  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
112322961  F11R; junctional adhesion molecule A [KO:K06089]
112323008  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
dro04520  Adherens junction
dro04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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