KEGG   PATHWAY: dro04020
Entry
dro04020                    Pathway                                
Name
Calcium signaling pathway - Desmodus rotundus (common vampire bat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
dro04020  Calcium signaling pathway
dro04020

Other DBs
GO: 0019722
Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112296254  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112296275  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
112296376  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
112296393  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
112296400  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
112296690  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
112296774  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
112296778  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
112296834  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
112297038  PLN; cardiac phospholamban [KO:K05852]
112297238  TRDN; triadin [KO:K23449]
112297397  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
112297606  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
112297750  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
112297858  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
112297939  CALM2; calmodulin-2 [KO:K02183]
112297967  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
112298164  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
112298360  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
112298798  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
112298878  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
112298903  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
112298991  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
112299554  PTAFR; platelet-activating factor receptor [KO:K04279]
112299615  CALML6; calmodulin-like protein 6 [KO:K02183]
112299910  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
112300051  [KO:K05096] [EC:2.7.10.1]
112300102  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
112300171  ADRB1; beta-1 adrenergic receptor [KO:K04141]
112300272  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
112300351  [KO:K04636]
112300359  [KO:K04634]
112300421  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
112300468  [KO:K04358]
112300562  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
112300586  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
112300608  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
112300725  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
112300806  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
112301009  AGTR1; type-1 angiotensin II receptor [KO:K04166]
112301078  [KO:K02183]
112301133  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
112301160  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
112301212  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
112301248  HRH1; histamine H1 receptor [KO:K04149]
112301287  OXTR; oxytocin receptor [KO:K04229]
112301443  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
112301523  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112301849  P2RX6; LOW QUALITY PROTEIN: P2X purinoceptor 6 [KO:K05221]
112301943  [KO:K05863]
112301961  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112302101  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
112302143  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
112302164  TFEB; transcription factor EB [KO:K15590]
112302323  FGF6; fibroblast growth factor 6 [KO:K04358]
112303034  TGFA; protransforming growth factor alpha [KO:K08774]
112303041  [KO:K15040]
112303066  TACR1; substance-P receptor [KO:K04222]
112303707  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
112303826  [KO:K04632]
112303827  [KO:K04632]
112303845  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
112303889  NTSR1; neurotensin receptor type 1 [KO:K04211]
112303992  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
112304012  TNNC2; troponin C, skeletal muscle [KO:K12042]
112304122  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
112304147  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
112304255  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
112304477  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
112304506  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
112304508  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
112304763  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
112304780  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
112304795  ORAI3; protein orai-3 [KO:K16058]
112304830  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
112305089  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
112305225  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
112305248  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112305359  VDAC2; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2 [KO:K15040]
112305445  MRLN; myoregulin [KO:K22643]
112305449  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112305450  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
112305463  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
112305493  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
112305517  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
112305598  TACR2; substance-K receptor [KO:K04223]
112305800  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
112305916  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
112305954  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
112306096  RYR2; ryanodine receptor 2 [KO:K04962]
112306123  [KO:K04809]
112306277  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
112306604  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
112306665  VEGFC; vascular endothelial growth factor C [KO:K05449]
112306713  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
112306733  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112306765  ADRB3; beta-3 adrenergic receptor [KO:K04143]
112306790  FGF20; fibroblast growth factor 20 [KO:K04358]
112306844  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
112306861  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
112306912  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
112306914  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
112307030  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
112307128  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
112307173  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
112307367  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
112307376  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
112307510  F2R; proteinase-activated receptor 1 [KO:K03914]
112307665  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
112307700  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
112307779  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
112308251  HTR2C; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2C [KO:K04157]
112308288  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
112308350  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
112308396  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
112308600  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
112308785  ADORA2B; adenosine receptor A2b [KO:K04267]
112308939  P2RX1; P2X purinoceptor 1 [KO:K05215]
112308940  P2RX5; P2X purinoceptor 5 [KO:K05219]
112309247  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
112309255  MCOLN2; mucolipin-2 [KO:K04993]
112309317  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
112309331  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
112309395  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
112309412  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
112309625  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
112309785  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
112309793  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
112309809  MST1; LOW QUALITY PROTEIN: hepatocyte growth factor-like protein [KO:K23441]
112310055  FGF21; fibroblast growth factor 21 [KO:K22429]
112310060  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
112310074  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
112310185  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
112310326  P2RX7; P2X purinoceptor 7 [KO:K05220]
112310430  P2RX2; P2X purinoceptor 2 [KO:K05216]
112310459  P2RX4; P2X purinoceptor 4 [KO:K05218]
112310580  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
112310607  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
112310614  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
112310624  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
112310718  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
112310821  EDNRB; endothelin receptor type B [KO:K04198]
112310837  ADORA2A; adenosine receptor A2a [KO:K04266]
112310964  BDKRB1; B1 bradykinin receptor [KO:K03915]
112311063  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
112311203  BDKRB2; B2 bradykinin receptor [KO:K03916]
112311250  CALM1; calmodulin-1 [KO:K02183]
112311289  CYSLTR2; LOW QUALITY PROTEIN: cysteinyl leukotriene receptor 2 [KO:K04323]
112311437  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
112311468  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
112311484  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
112311702  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
112311746  FGF7; fibroblast growth factor 7 [KO:K04358]
112311842  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
112312202  TBXA2R; thromboxane A2 receptor [KO:K04264]
112312217  FGF2; fibroblast growth factor 2 [KO:K18497]
112312285  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
112312291  FGF22; fibroblast growth factor 22 [KO:K04358]
112312413  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
112312418  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
112312435  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
112312459  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
112312642  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
112312671  PDGFC; platelet-derived growth factor C [KO:K05450]
112312673  EDNRA; endothelin-1 receptor [KO:K04197]
112312797  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
112312910  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
112312926  CALM3; calmodulin-3 [KO:K02183]
112313052  [KO:K04161]
112313099  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
112313233  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
112313387  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
112313406  GRPR; gastrin-releasing peptide receptor [KO:K04169]
112313412  VEGFD; vascular endothelial growth factor D [KO:K05449]
112313639  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
112313781  NGF; beta-nerve growth factor [KO:K02582]
112313812  CASQ2; calsequestrin-2 [KO:K23445]
112314275  SLN; sarcolipin [KO:K22642]
112314347  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
112314689  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
112314772  CASQ1; calsequestrin-1 [KO:K23468]
112314866  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
112314932  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
112314985  AVPR1B; vasopressin V1b receptor [KO:K04227]
112315044  ORAI2; protein orai-2 [KO:K16057]
112315295  FGF10; LOW QUALITY PROTEIN: fibroblast growth factor 10 [KO:K04358]
112315321  [KO:K00476] [EC:1.14.11.16]
112315487  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
112315577  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
112315668  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
112315975  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
112316028  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
112316206  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
112316215  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
112316515  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112316692  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
112316721  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
112316796  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
112316868  CCKAR; cholecystokinin receptor type A [KO:K04194]
112316912  DRD5; D(1B) dopamine receptor [KO:K05840]
112316918  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
112317151  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
112317249  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
112317329  TPCN2; two pore calcium channel protein 2 [KO:K14077]
112317384  VEGFB; vascular endothelial growth factor B [KO:K16858]
112317418  FGF19; fibroblast growth factor 19 [KO:K22603]
112317419  FGF4; fibroblast growth factor 4 [KO:K04358]
112317420  FGF3; fibroblast growth factor 3 [KO:K04358]
112317689  TACR3; neuromedin-K receptor [KO:K04224]
112317852  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
112317863  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
112317949  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
112317958  FGF16; LOW QUALITY PROTEIN: fibroblast growth factor 16 [KO:K04358]
112318067  FGF1; fibroblast growth factor 1 [KO:K18496]
112318103  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
112318376  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
112318382  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
112318404  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
112318678  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
112318756  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
112318787  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
112319025  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
112319115  AVPR1A; vasopressin V1a receptor [KO:K04226]
112319441  HRH2; histamine H2 receptor [KO:K04150]
112319490  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
112319561  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
112319577  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
112319603  ADRB2; beta-2 adrenergic receptor [KO:K04142]
112319624  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
112319688  DRD1; D(1A) dopamine receptor [KO:K04144]
112319696  FGF18; fibroblast growth factor 18 [KO:K04358]
112319711  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
112319719  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
112319987  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
112320012  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
112320299  P2RX3; P2X purinoceptor 3 [KO:K05217]
112320339  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
112320512  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
112321008  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112321120  [KO:K02183]
112321122  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
112321262  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112321447  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
112321825  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
112322024  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
112322357  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
112322569  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
112322654  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
112322693  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
112322988  CALML3; calmodulin-like protein 3 [KO:K02183]
112323117  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
112323185  FGF9; fibroblast growth factor 9 [KO:K04358]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
dro04010  MAPK signaling pathway
dro04070  Phosphatidylinositol signaling system
dro04210  Apoptosis
dro04720  Long-term potentiation
dro04730  Long-term depression
KO pathway
ko04020   

DBGET integrated database retrieval system