KEGG   PATHWAY: ecb04514
Entry
ecb04514                    Pathway                                
Name
Cell adhesion molecule (CAM) interaction - Equus caballus (horse)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ecb04514  Cell adhesion molecule (CAM) interaction
ecb04514

Other DBs
GO: 0050839
Organism
Equus caballus (horse) [GN:ecb]
Gene
100009695  SELP; P-selectin [KO:K06496]
100033910  SELE; E-selectin precursor [KO:K06494]
100034024  MPZ; myelin protein P0 precursor [KO:K06770]
100034025  SELPLG; P-selectin glycoprotein ligand 1 precursor [KO:K06544]
100034049  CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]
100034205  CD2; T-cell surface antigen CD2 precursor [KO:K06449]
100034210  EQMHCB2; MHC class I heavy chain precursor [KO:K06751]
100034211  EQMHCC1; MHC class I heavy chain precursor [KO:K06751]
100034212  MHCB3; MHC class I heavy chain precursor [KO:K06751]
100049798  [KO:K06751]
100049925  CNTN1; contactin-1 isoform X1 [KO:K06759]
100049944  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
100050179  CNTN2; contactin-2 isoform X1 [KO:K06760]
100050220  SLITRK1; SLIT and NTRK-like protein 1 precursor [KO:K25832]
100050252  VCAM1; vascular cell adhesion protein 1 precursor [KO:K06527]
100050289  SLITRK5; SLIT and NTRK-like protein 5 [KO:K25836]
100050473  [KO:K06751]
100050509  CLDN10; claudin-10 [KO:K06087]
100050550  EQMCE1; MHC class I antigen 3.7 precursor [KO:K06751]
100050706  [KO:K06751]
100050709  NLGN4X; neuroligin-4, X-linked isoform X2 [KO:K07378]
100050806  MAG; myelin-associated glycoprotein isoform X1 [KO:K06771]
100050997  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
100051657  [KO:K06751]
100051703  CD274; programmed cell death 1 ligand 1 [KO:K06745]
100051718  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
100051767  CLDN14; claudin-14 [KO:K06087]
100051771  CDH15; cadherin-15 [KO:K06809]
100051885  PTPRD; receptor-type tyrosine-protein phosphatase delta [KO:K06777] [EC:3.1.3.48]
100051944  DRA; MHC class II DR alpha chain precursor [KO:K06752]
100052006  DRB; MHC class II DR-beta chain precursor [KO:K06752]
100052046  CD276; CD276 antigen [KO:K06746]
100052063  DQA; MHC class II DQ-alpha chain [KO:K06752]
100052125  DQA; MHC class II DQ-alpha chain precursor [KO:K06752]
100052184  DQB; MHC class II DQ-beta chain precursor [KO:K06752]
100052249  DQA; MHC class II DQ-alpha precursor [KO:K06752]
100052310  DRB; MHC class II DR-beta chain precursor [KO:K06752]
100052364  DRB; MHC class II DR-beta chain precursor [KO:K06752]
100052467  CNTNAP1; contactin-associated protein 1 [KO:K07379]
100052502  CD4; T-cell surface glycoprotein CD4 isoform X2 [KO:K06454]
100052855  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
100052908  NRXN1; neurexin-1 isoform X1 [KO:K07377]
100053205  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
100053379  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
100053444  CLDN18; claudin-18 isoform X1 [KO:K06087]
100053462  ITGB8; integrin beta-8 [KO:K06591]
100053464  NEGR1; neuronal growth regulator 1 precursor [KO:K06775]
100053505  CLDN8; claudin-8 [KO:K06087]
100053552  CLDN17; claudin-17 [KO:K06087]
100053591  CLDN19; claudin-19 [KO:K06087]
100053905  JAM2; junctional adhesion molecule B [KO:K06735]
100053918  [KO:K06751]
100054114  [KO:K06751]
100054374  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
100054397  [KO:K06751]
100054448  [KO:K06751]
100054575  NFASC; neurofascin isoform X3 [KO:K06757]
100054624  CD40LG; CD40 ligand isoform X1 [KO:K03161]
100054776  CLDN2; claudin-2 isoform X1 [KO:K06087]
100055024  ITGB1; integrin beta-1 precursor [KO:K05719]
100055066  GLG1; Golgi apparatus protein 1 [KO:K06816]
100055684  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
100055730  SLITRK4; SLIT and NTRK-like protein 4 isoform X1 [KO:K25835]
100055823  NLGN3; neuroligin-3 isoform X2 [KO:K07378]
100055880  NRXN2; neurexin-2-beta isoform X1 [KO:K07377]
100056049  [KO:K06464]
100056062  [KO:K06751]
100056099  [KO:K06751]
100056128  ITGB2; integrin beta-2 [KO:K06464]
100056182  [KO:K06751]
100056217  ITGA8; integrin alpha-8 [KO:K06584]
100056231  [KO:K06751]
100056309  [KO:K06751]
100056391  MHCX1; MHC class I antigen 3.5 precursor [KO:K06751]
100056458  SLITRK6; SLIT and NTRK-like protein 6 precursor [KO:K25837]
100056742  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
100057048  ICOSLG; ICOS ligand isoform X1 [KO:K06710]
100057644  CLDN11; claudin-11 [KO:K06087]
100057648  CDH4; cadherin-4 [KO:K06797]
100057920  [KO:K06751]
100058013  NLGN1; neuroligin-1 isoform X3 [KO:K07378]
100058074  ICAM3; intercellular adhesion molecule 3 [KO:K06486]
100058207  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
100058663  SELL; L-selectin isoform X1 [KO:K06495]
100058890  [KO:K06087]
100058927  [KO:K06087]
100059024  L1CAM; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
100059542  PDCD1LG2; programmed cell death 1 ligand 2 [KO:K06708]
100059555  CLDN15; claudin-15 [KO:K06087]
100059645  NRXN3; neurexin 3 isoform X14 [KO:K07377]
100059664  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
100059727  SDC2; syndecan-2 isoform X2 [KO:K16336]
100059811  CLDN1; claudin-1 [KO:K06087]
100059922  CLDN3; claudin-3 [KO:K06087]
100059948  CLDN4; claudin-4 [KO:K06087]
100059994  [KO:K06751]
100060036  CD226; CD226 antigen isoform X1 [KO:K06567]
100060096  [KO:K06751]
100060296  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
100060320  DQB; MHC class II DQ-beta chain precursor [KO:K06752]
100060361  CLDN12; claudin-12 [KO:K06087]
100060362  NTNG1; netrin-G1 isoform X1 [KO:K07522]
100060531  [KO:K06752]
100060697  [KO:K06752]
100060767  CD86; T-lymphocyte activation antigen CD86 isoform X5 [KO:K05413]
100060770  [KO:K06752]
100060996  [KO:K06752]
100061035  [KO:K06752]
100061127  [KO:K06752]
100061848  ALCAM; CD166 antigen isoform X1 [KO:K06547]
100061950  PTPRC; receptor-type tyrosine-protein phosphatase C precursor [KO:K06478] [EC:3.1.3.48]
100062081  CD6; T-cell differentiation antigen CD6 isoform X1 [KO:K06456]
100062164  NCAM1; neural cell adhesion molecule 1 isoform X9 [KO:K06491]
100062374  CADM1; cell adhesion molecule 1 isoform X4 [KO:K06781]
100062876  JAML; junctional adhesion molecule-like [KO:K28137]
100063194  NEO1; neogenin isoform X1 [KO:K06766]
100063273  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
100063403  CLDN23; claudin-23 [KO:K06087]
100063411  NECTIN1; nectin-1 [KO:K06081]
100063747  ITGB7; integrin beta-7 isoform X2 [KO:K06590]
100064056  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100064309  PECAM1; platelet endothelial cell adhesion molecule precursor [KO:K06471]
100064394  CD99; CD99 antigen isoform X1 [KO:K06520]
100064400  ICAM2; intercellular adhesion molecule 2 isoform X1 [KO:K06523]
100064803  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
100065078  CDH2; cadherin-2 [KO:K06736]
100065253  CDH5; cadherin-5 [KO:K06533]
100065275  VCAN; versican core protein isoform X1 [KO:K06793]
100065463  NECTIN2; nectin-2 isoform X2 [KO:K06531]
100065508  ITGAL; integrin alpha-L isoform X2 [KO:K05718]
100065743  SPN; leukosialin [KO:K06477]
100065810  CLDN9; claudin-9 [KO:K06087]
100065839  CLDN6; claudin-6 [KO:K06087]
100066062  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
100066328  VTCN1; V-set domain-containing T-cell activation inhibitor 1 isoform X2 [KO:K06747]
100066351  SIGLEC1; sialoadhesin isoform X1 [KO:K06548]
100066720  F11R; junctional adhesion molecule A [KO:K06089]
100066774  CD8A; T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458]
100066779  CDH3; cadherin-3 isoform X1 [KO:K06796]
100066844  CDH1; cadherin-1 [KO:K05689]
100067189  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
100067795  CXADR; coxsackievirus and adenovirus receptor isoform X1 [KO:K06788]
100067829  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
100067886  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
100067931  CTLA4; cytotoxic T-lymphocyte protein 4 isoform X1 [KO:K06538]
100067948  PDCD1; programmed cell death protein 1 isoform X1 [KO:K06744]
100067953  ICOS; inducible T-cell costimulator isoform X2 [KO:K06713]
100068635  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
100068706  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100069501  NTNG2; netrin-G2 isoform X1 [KO:K16359]
100069582  CD99L2; CD99 antigen-like protein 2 isoform X1 [KO:K06520]
100070525  SDC3; syndecan-3 [KO:K16337]
100070567  [KO:K06539]
100070727  CLDN25; putative claudin-25 [KO:K06087]
100070934  SDC4; syndecan-4 [KO:K16338]
100071012  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
100071118  IGSF11; immunoglobulin superfamily member 11 isoform X2 [KO:K06791]
100071301  TIGIT; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
100071640  NECTIN3; nectin-3 isoform X1 [KO:K06592]
100071892  SDC1; syndecan-1 isoform X1 [KO:K06257]
100072264  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
100072872  JAM3; junctional adhesion molecule C isoform X1 [KO:K06785]
100072960  CLDN7; claudin-7 [KO:K06087]
100072981  NLGN2; neuroligin-2 isoform X1 [KO:K07378]
100073306  OCLN; occludin isoform X1 [KO:K06088]
100146202  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
100146402  CD22; B-cell receptor CD22 isoform X2 [KO:K06467]
100630336  CLDN34; claudin-34 [KO:K06087]
100630753  CLDN20; LOW QUALITY PROTEIN: claudin-20 [KO:K06087]
102149057  CLDN5; claudin-5 [KO:K06087]
102149135  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
102149682  PTPRS; receptor-type tyrosine-protein phosphatase S isoform X1 [KO:K06778] [EC:3.1.3.48]
102149832  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
106783094  [KO:K10785]
111767408  [KO:K06087]
111767457  [KO:K06752]
111772100  [KO:K10784]
111772209  [KO:K06087]
111773318  [KO:K07380]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
ecb04520  Adherens junction
ecb04530  Tight junction
ecb04610  Complement and coagulation cascades
ecb04660  T cell receptor signaling pathway
ecb04670  Leukocyte transendothelial migration
KO pathway
ko04514   

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