Entry Name B cell receptor signaling pathway - Enhydra lutris kenyoni (northern sea otter)
Description B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map elk04662 B cell receptor signaling pathway
Ortholog table Other DBs Organism Enhydra lutris kenyoni (northern sea otter) [GN:
elk ]
Gene 111139538 B-cell antigen receptor complex-associated protein alpha chain [KO:K06506 ]
111158187 B-cell antigen receptor complex-associated protein beta chain isoform X1 [KO:K06507 ]
111154926 dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [KO:K12229 ]
111145636 ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
111160304 ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
111154080 B-cell scaffold protein with ankyrin repeats isoform X1 [KO:K26239 ]
111144797 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
111154144 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
111154566 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
111154209 nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
111141582 LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332 ]
111152752 nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
111145457 caspase recruitment domain-containing protein 11 isoform X1 [KO:K07367 ]
111154234 mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369 ] [EC:3.4.22.-]
111143470 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
111155224 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
111143790 phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
111155003 LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
111154641 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
111139555 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X1 [KO:K06512 ]
111140050 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
111140043 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 1 [KO:K06512 ]
111140495 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
111139554 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
111144693 phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Niiro H, Clark EA.
Title Regulation of B-cell fate by antigen-receptor signals.
Journal Reference Authors Kurosaki T.
Title Genetic analysis of B cell antigen receptor signaling.
Journal Reference Authors Nitschke L.
Title The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal Reference Authors Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title Complement: central to innate immunity and bridging to adaptive responses.
Journal Reference Authors Kurosaki T.
Title Regulation of B-cell signal transduction by adaptor proteins.
Journal Reference Authors Nitschke L, Tsubata T.
Title Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal Reference Authors Jumaa H, Hendriks RW, Reth M.
Title B cell signaling and tumorigenesis.
Journal Reference Authors Rickert RC.
Title Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal Reference Authors Zouali M, Sarmay G
Title B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal Reference Authors Chiles TC.
Title Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal Reference Authors Allam A, Marshall AJ
Title Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal Reference Authors Gold MR
Title To make antibodies or not: signaling by the B-cell antigen receptor.
Journal Reference Authors Fu C, Turck CW, Kurosaki T, Chan AC
Title BLNK: a central linker protein in B cell activation.
Journal Reference Authors Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal Reference Authors Shinohara H, Maeda S, Watarai H, Kurosaki T
Title IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal Related elk04610 Complement and coagulation cascades
elk04810 Regulation of actin cytoskeleton
KO pathway LinkDB All DBs
