Entry Name B cell receptor signaling pathway
Description B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map ko04662 B cell receptor signaling pathway
Other DBs Orthology K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K02581 NFKBIB; NF-kappa-B inhibitor beta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K03084 SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86 ]
K04012 CR2, CD21; complement receptor type 2
K04348 PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16 ]
K04364 GRB2; growth factor receptor-bound protein 2
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2 ]
K04369 MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2 ]
K04379 FOS; proto-oncogene protein c-fos
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K04446 NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
K04448 JUN; transcription factor AP-1
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10 ]
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K04735 RELA; transcription factor p65
K05697 PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48 ]
K05730 VAV; guanine nucleotide exchange factor VAV
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11 ]
K05872 NFKBIE; NF-kappa-B inhibitor epsilon
K06268 PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
K06465 CD19; B-lymphocyte antigen CD19
K06467 CD22, SIGLEC2; CD22 antigen
K06506 CD79A, IGA; CD79A antigen
K06507 CD79B, IGB; CD79B antigen
K06508 CD81, TAPA1, TSPAN28; CD81 antigen
K06512 LILR, CD85; leukocyte immunoglobulin-like receptor
K06856 IGH; immunoglobulin heavy chain
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10 ]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07367 CARD11; caspase recruitment domain-containing protein 11
K07368 BCL10; B-cell CLL/lymphoma 10
K07369 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
K07371 BLNK; B-cell linker protein
K07827 KRAS, KRAS2; GTPase KRas
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K12229 DAPP1, BAM32; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
K12230 PIK3AP1, BCAP; phosphoinositide 3-kinase adapter protein 1
K12362 RASGRP3; RAS guanyl-releasing protein 3
K12560 FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b
K15909 SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86 ]
K17332 NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2
K17333 NFATC3, NFAT4; nuclear factor of activated T-cells, cytoplasmic 3
K19831 IFITM1, CD225; interferon induced transmembrane protein 1
K26239 BANK1; B-cell scaffold protein with ankyrin repeats
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Niiro H, Clark EA.
Title Regulation of B-cell fate by antigen-receptor signals.
Journal Reference Authors Kurosaki T.
Title Genetic analysis of B cell antigen receptor signaling.
Journal Reference Authors Nitschke L.
Title The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal Reference Authors Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title Complement: central to innate immunity and bridging to adaptive responses.
Journal Reference Authors Kurosaki T.
Title Regulation of B-cell signal transduction by adaptor proteins.
Journal Reference Authors Nitschke L, Tsubata T.
Title Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal Reference Authors Jumaa H, Hendriks RW, Reth M.
Title B cell signaling and tumorigenesis.
Journal Reference Authors Rickert RC.
Title Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal Reference Authors Zouali M, Sarmay G
Title B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal Reference Authors Chiles TC.
Title Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal Reference Authors Allam A, Marshall AJ
Title Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal Reference Authors Gold MR
Title To make antibodies or not: signaling by the B-cell antigen receptor.
Journal Reference Authors Fu C, Turck CW, Kurosaki T, Chan AC
Title BLNK: a central linker protein in B cell activation.
Journal Reference Authors Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal Reference Authors Shinohara H, Maeda S, Watarai H, Kurosaki T
Title IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal Related ko04064 NF-kappa B signaling pathway
ko04120 Ubiquitin mediated proteolysis
ko04610 Complement and coagulation cascades
ko04810 Regulation of actin cytoskeleton
