KEGG   PATHWAY: els04070
Entry
els04070                    Pathway                                
Name
Phosphatidylinositol signaling system - Esox lucius (northern pike)
Class
Environmental Information Processing; Signal transduction
Pathway map
els04070  Phosphatidylinositol signaling system
els04070

Organism
Esox lucius (northern pike) [GN:els]
Gene
105006191  ipmk; inositol polyphosphate multikinase isoform X1 [KO:K00915] [EC:2.7.1.140 2.7.1.151]
105006284  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105006454  mtmr8; myotubularin-related protein 8 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
105006615  ocrl; inositol polyphosphate 5-phosphatase OCRL-1 isoform X1 [KO:K01099] [EC:3.1.3.36]
105006704  pip4p2; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X2 [KO:K13084] [EC:3.1.3.78]
105006710  pi4ka; phosphatidylinositol 4-kinase alpha isoform X2 [KO:K00888] [EC:2.7.1.67]
105006788  impad1; inositol monophosphatase 3 isoform X1 [KO:K15759] [EC:3.1.3.7]
105006851  [KO:K13711] [EC:2.7.1.67]
105007096  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
105007252  [KO:K05857] [EC:3.1.4.11]
105008024  synj1; synaptojanin-1 isoform X1 [KO:K20279] [EC:3.1.3.36]
105008260  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
105008609  [KO:K00889] [EC:2.7.1.68]
105008910  ip6k1; inositol hexakisphosphate kinase 1 [KO:K07756] [EC:2.7.4.21]
105009402  [KO:K19662] [EC:2.7.11.13]
105009929  [KO:K00922] [EC:2.7.1.153]
105010329  plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
105010650  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105010721  inpp5a; type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [KO:K01106] [EC:3.1.3.56]
105011662  pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
105011838  [KO:K00911] [EC:2.7.1.127]
105011953  [KO:K01116] [EC:3.1.4.11]
105012083  calm3; calmodulin-3 [KO:K02183]
105012328  [KO:K21797] [EC:3.1.3.-]
105012700  [KO:K19801] [EC:2.7.1.67]
105013487  ippk; inositol-pentakisphosphate 2-kinase isoform X1 [KO:K10572] [EC:2.7.1.158]
105013615  pip4k2c; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
105013934  [KO:K02183]
105013964  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105014130  inpp5e; 72 kDa inositol polyphosphate 5-phosphatase [KO:K20278] [EC:3.1.3.36]
105014193  mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
105014248  [KO:K01106] [EC:3.1.3.56]
105014287  [KO:K00889] [EC:2.7.1.68]
105014360  [KO:K00981] [EC:2.7.7.41]
105014571  cds1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
105015023  [KO:K13024] [EC:2.7.4.24]
105015056  [KO:K00889] [EC:2.7.1.68]
105015144  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105015473  calm1; calmodulin [KO:K02183]
105015588  [KO:K00913] [EC:2.7.1.159 2.7.1.134]
105015712  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105015741  [KO:K00911] [EC:2.7.1.127]
105016179  plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
105016282  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
105016301  [KO:K00901] [EC:2.7.1.107]
105016798  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923] [EC:2.7.1.154]
105016973  [KO:K00920] [EC:2.7.1.149]
105017006  [KO:K04958]
105017082  inpp1; inositol polyphosphate 1-phosphatase [KO:K01107] [EC:3.1.3.57]
105017091  [KO:K00901] [EC:2.7.1.107]
105017178  ip6k2; inositol hexakisphosphate kinase 2 [KO:K07756] [EC:2.7.4.21]
105017428  [KO:K04958]
105017520  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
105017521  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105017670  [KO:K00913] [EC:2.7.1.159 2.7.1.134]
105017693  [KO:K02183]
105017751  itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
105018471  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
105018577  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105018659  [KO:K02183]
105018666  [KO:K00901] [EC:2.7.1.107]
105018870  [KO:K19801] [EC:2.7.1.67]
105019084  [KO:K19663] [EC:2.7.11.13]
105019184  sacm1l; phosphatidylinositide phosphatase SAC1 isoform X1 [KO:K21797] [EC:3.1.3.-]
105019513  impa2; inositol monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
105019823  [KO:K01109] [EC:3.1.3.66]
105020458  [KO:K13024] [EC:2.7.4.24]
105020543  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
105020814  pi4k2b; phosphatidylinositol 4-kinase type 2-beta [KO:K13711] [EC:2.7.1.67]
105020950  inpp4b; type II inositol 3,4-bisphosphate 4-phosphatase isoform X1 [KO:K01109] [EC:3.1.3.66]
105021026  [KO:K18083] [EC:3.1.3.64 3.1.3.95]
105021390  [KO:K13711] [EC:2.7.1.67]
105021417  [KO:K05860] [EC:3.1.4.11]
105021458  pip4k2b; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
105021553  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
105021568  [KO:K02677] [EC:2.7.11.13]
105021897  dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
105021916  dgkh; diacylglycerol kinase eta isoform X4 [KO:K00901] [EC:2.7.1.107]
105021974  [KO:K02649]
105022032  pip4k2a; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
105022141  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
105022262  [KO:K00889] [EC:2.7.1.68]
105022307  dgka; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
105022523  [KO:K05857] [EC:3.1.4.11]
105022998  [KO:K05857] [EC:3.1.4.11]
105024545  [KO:K02649]
105024555  pip4p1; type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase [KO:K13084] [EC:3.1.3.78]
105024794  mtmr14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
105025109  [KO:K01092] [EC:3.1.3.25]
105025138  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4 [KO:K05860] [EC:3.1.4.11]
105025378  [KO:K02649]
105025440  calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105025643  mtmr6; myotubularin-related protein 6 isoform X2 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
105025667  [KO:K00901] [EC:2.7.1.107]
105025897  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105025988  mtmr2; myotubularin-related protein 2 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
105026133  [KO:K02677] [EC:2.7.11.13]
105026229  [KO:K02649]
105026550  [KO:K18083] [EC:3.1.3.64 3.1.3.95]
105026737  [KO:K00911] [EC:2.7.1.127]
105026926  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105026977  [KO:K00911] [EC:2.7.1.127]
105027176  inpp5b; type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X2 [KO:K01099] [EC:3.1.3.36]
105027324  dgkz; diacylglycerol kinase zeta isoform X3 [KO:K00901] [EC:2.7.1.107]
105027659  mtmr1; myotubularin-related protein 1 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
105027660  mtm1; myotubularin [KO:K01108] [EC:3.1.3.64 3.1.3.95]
105027760  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
105028068  [KO:K02183]
105028228  [KO:K00901] [EC:2.7.1.107]
105028542  [KO:K13024] [EC:2.7.4.24]
105028642  inpp5f; phosphatidylinositide phosphatase SAC2 [KO:K21798] [EC:3.1.3.-]
105028898  pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [KO:K00923] [EC:2.7.1.154]
105028918  [KO:K00922] [EC:2.7.1.153]
105029118  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
105029228  [KO:K00889] [EC:2.7.1.68]
105029544  inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1 [KO:K03084] [EC:3.1.3.86]
105029605  inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1 [KO:K15909] [EC:3.1.3.86]
105029822  dgkd; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
105029903  dgkq; diacylglycerol kinase theta isoform X2 [KO:K00901] [EC:2.7.1.107]
105030417  [KO:K05857] [EC:3.1.4.11]
105030639  [KO:K13084] [EC:3.1.3.78]
105030718  prkcb; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
105030792  calm2; calmodulin [KO:K02183]
105031134  [KO:K00888] [EC:2.7.1.67]
105031582  [KO:K01092] [EC:3.1.3.25]
105031658  [KO:K05858] [EC:3.1.4.11]
106023667  mtmr4; myotubularin-related protein 4 isoform X6 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
109614581  [KO:K02649]
109614610  [KO:K07756] [EC:2.7.4.21]
114839877  [KO:K02183]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
els04020  Calcium signaling pathway
els04144  Endocytosis
els04510  Focal adhesion
KO pathway
ko04070   

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