KEGG   PATHWAY: etf03015
Entry
etf03015                    Pathway                                
Name
mRNA surveillance pathway - Echinops telfairi (small Madagascar hedgehog)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
etf03015  mRNA surveillance pathway
etf03015

Other DBs
GO: 0071028
Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101638709  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101639377  [KO:K12877]
101639916  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
101640283  SMG6; telomerase-binding protein EST1A isoform X2 [KO:K11124] [EC:3.1.-.-]
101640523  CPSF3; cleavage and polyadenylation specificity factor subunit 3 isoform X1 [KO:K14403] [EC:3.1.27.-]
101640624  CPSF1; cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
101640723  GLE1; mRNA export factor GLE1 [KO:K18723]
101641573  CSTF1; cleavage stimulation factor subunit 1 [KO:K14406]
101641623  SMG1; serine/threonine-protein kinase SMG1 [KO:K08873] [EC:2.7.11.1]
101641638  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
101641890  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
101641970  [KO:K13126]
101642120  CPSF6; cleavage and polyadenylation specificity factor subunit 6 isoform X1 [KO:K14398]
101642174  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
101642432  CSTF2T; cleavage stimulation factor subunit 2 tau variant [KO:K14407]
101643138  PAPOLA; poly(A) polymerase alpha isoform X1 [KO:K14376] [EC:2.7.7.19]
101643619  CASC3; protein CASC3 [KO:K14323]
101644179  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101644319  [KO:K04382] [EC:3.1.3.16]
101645049  WDR82; WD repeat-containing protein 82 [KO:K14962]
101645306  [KO:K18655] [EC:5.6.2.7]
101645417  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
101645864  PAPOLG; poly(A) polymerase gamma isoform X1 [KO:K14376] [EC:2.7.7.19]
101646944  SMG5; protein SMG5 [KO:K11125]
101647042  ETF1; eukaryotic peptide chain release factor subunit 1 [KO:K03265]
101647311  RNMT; mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
101647410  HBS1L; HBS1-like protein isoform X1 [KO:K14416]
101647612  [KO:K14284]
101647744  [KO:K03456]
101648204  PABPC1; polyadenylate-binding protein 1 [KO:K13126]
101648473  PABPC4; polyadenylate-binding protein 4 [KO:K13126]
101648549  [KO:K14284]
101648942  DAZAP1; DAZ-associated protein 1 [KO:K14411]
101650054  PCF11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X2 [KO:K14400]
101650421  [KO:K14284]
101650450  CSTF3; cleavage stimulation factor subunit 3 [KO:K14408]
101650456  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
101650540  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
101651322  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X2 [KO:K11583]
101651361  GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
101651647  [KO:K12877]
101651662  PELO; protein pelota homolog [KO:K06965]
101651726  CLP1; polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
101652247  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
101652256  [KO:K14294]
101652315  CSTF2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407]
101652706  WDR33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
101652744  SYMPK; symplekin [KO:K06100]
101652766  NXF1; nuclear RNA export factor 1 [KO:K14284]
101652957  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
101652960  PABPC4L; polyadenylate-binding protein 4-like [KO:K13126]
101653156  [KO:K14324]
101653184  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101653885  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
101654182  NUDT21; cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
101654323  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
101654461  [KO:K12876]
101655106  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
101655698  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101655708  PABPC1L; polyadenylate-binding protein 1-like [KO:K13126]
101655909  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
101656406  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
101656573  [KO:K06269] [EC:3.1.3.16]
101656646  CPSF2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
101657070  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101657344  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101657408  SRRM1; serine/arginine repetitive matrix protein 1 [KO:K13171]
101657569  PNN; pinin [KO:K13114]
101657966  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101658147  [KO:K14285]
101658335  [KO:K03265]
101658403  GSPT2; eukaryotic peptide chain release factor GTP-binding subunit ERF3B [KO:K03267]
101659001  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
101659013  MSI1; RNA-binding protein Musashi homolog 1 isoform X1 [KO:K14411]
101659349  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
101659399  NXT1; NTF2-related export protein 1 [KO:K14285]
101659853  [KO:K13126]
101659885  CPSF7; cleavage and polyadenylation specificity factor subunit 7 isoform X2 [KO:K14398]
101660199  [KO:K14396]
101660246  SMG7; protein SMG7 isoform X2 [KO:K14409]
101660860  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
101660876  UPF1; regulator of nonsense transcripts 1 isoform X6 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
101661129  [KO:K15544] [EC:3.1.3.16]
101661190  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
101661877  [KO:K11125]
101661941  FIP1L1; pre-mRNA 3'-end-processing factor FIP1 [KO:K14405]
101662062  RNGTT; mRNA-capping enzyme isoform X2 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
101662513  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
101662642  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
101662798  PABPC5; polyadenylate-binding protein 5 isoform X1 [KO:K13126]
101662896  MSI2; RNA-binding protein Musashi homolog 2 isoform X3 [KO:K14411]
101663260  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X3 [KO:K12875]
101663474  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101663715  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
101663827  SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
101663845  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
101663948  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101664005  [KO:K14284]
101664419  PYM1; partner of Y14 and mago [KO:K14294]
101664446  [KO:K23600]
105978697  [KO:K14396]
105978698  [KO:K14396]
105978709  [KO:K14396]
105978911  PAPOLB; poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
123520875  [KO:K18655] [EC:5.6.2.7]
123521716  [KO:K14284]
123521723  [KO:K14284]
123521724  [KO:K14284]
123521725  [KO:K14284]
123521751  [KO:K14284]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
etf03013  Nucleocytoplasmic transport
etf03018  RNA degradation
etf03040  Spliceosome
KO pathway
ko03015   

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