Entry Name Gastric acid secretion - Felis catus (domestic cat)
Description Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetycholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+,K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H+ secretion into the stomach lumen.
Class Organismal Systems; Digestive systemBRITE hierarchy
Pathway map Other DBs Organism Felis catus (domestic cat) [GN:
fca ]
Gene 101081858 ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
101084342 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
101086335 KCNE2; potassium voltage-gated channel subfamily E member 2 isoform X3 [KO:K04896 ]
101087993 ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960 ]
101089679 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
101090005 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
101090942 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
101091140 KCNJ1; ATP-sensitive inward rectifier potassium channel 1 isoform X2 [KO:K04995 ]
101091456 KCNK10; potassium channel subfamily K member 10 isoform X1 [KO:K04920 ]
101092262 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
101092644 KCNQ1; potassium voltage-gated channel subfamily KQT member 1 isoform X1 [KO:K04926 ]
101092837 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
101092961 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
101094708 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634 ]
101096695 KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913 ]
101097297 KCNJ10; ATP-sensitive inward rectifier potassium channel 10 isoform X4 [KO:K05003 ]
101097586 ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540 ]
101098090 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
101098221 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4 [KO:K04515 ] [EC:2.7.11.17 ]
101098615 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515 ] [EC:2.7.11.17 ]
101098743 CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195 ]
101100214 CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183 ]
101100258 ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X3 [KO:K01540 ]
101100320 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
101100322 KCNJ15; ATP-sensitive inward rectifier potassium channel 15 [KO:K05008 ]
101100546 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958 ]
101101230 ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Schubert ML, Peura DA
Title Control of gastric acid secretion in health and disease.
Journal Reference Authors Urushidani T, Forte JG
Title Signal transduction and activation of acid secretion in the parietal cell.
Journal Reference Authors Yao X, Forte JG
Title Cell biology of acid secretion by the parietal cell.
Journal Reference Authors Heitzmann D, Warth R
Title No potassium, no acid: K+ channels and gastric acid secretion.
Journal Reference Authors Kopic S, Murek M, Geibel JP
Title Revisiting the parietal cell.
Journal Reference Authors Schubert ML
Title Gastric secretion.
Journal Reference Authors Konturek SJ, Konturek PC, Brzozowski T, Konturek JW, Pawlik WW
Title From nerves and hormones to bacteria in the stomach; Nobel prize for achievements in gastrology during last century.
Journal J Physiol Pharmacol 56:507-30 (2005)
Reference Authors Forte JG, Zhu L
Title Apical recycling of the gastric parietal cell H,K-ATPase.
Journal Reference Authors Szaszak M, Christian F, Rosenthal W, Klussmann E
Title Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
Journal Reference Authors Heitzmann D, Warth R
Title Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
Journal Reference Authors Heitzmann D, Grahammer F, von Hahn T, Schmitt-Graff A, Romeo E, Nitschke R, Gerlach U, Lang HJ, Verrey F, Barhanin J, Warth R
Title Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells.
Journal Reference Authors Seidler U, Song P, Xiao F, Riederer B, Bachmann O, Chen M
Title Recent advances in the molecular and functional characterization of acid/base and electrolyte transporters in the basolateral membranes of gastric and duodenal epithelial cells.
Journal Related fca04974 Protein digestion and absorption
KO pathway
