KEGG   PATHWAY: fca04530
Entry
fca04530                    Pathway                                
Name
Tight junction - Felis catus (domestic cat)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
fca04530  Tight junction
fca04530

Other DBs
GO: 0005923
Organism
Felis catus (domestic cat) [GN:fca]
Gene
100037407  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100144392  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101080691  CLDN2; claudin-2 [KO:K06087]
101080704  PCNA; proliferating cell nuclear antigen [KO:K04802]
101080762  [KO:K06448]
101080871  MSN; moesin [KO:K05763]
101080975  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
101081005  CLDN5; claudin-5 [KO:K06087]
101081026  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X2 [KO:K21066]
101081032  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
101081075  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
101081208  CLDN12; claudin-12 [KO:K06087]
101081274  [KO:K06448]
101081386  AFDN; afadin isoform X1 [KO:K05702]
101081681  TJP2; tight junction protein ZO-2 isoform X3 [KO:K06098]
101081691  CLDN15; claudin-15 [KO:K06087]
101081992  [KO:K07374]
101082020  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101082083  CLDN14; claudin-14 isoform X2 [KO:K06087]
101082238  TJP1; tight junction protein ZO-1 isoform X6 [KO:K05701]
101082454  [KO:K04393]
101082861  MYH10; myosin-10 isoform X1 [KO:K10352]
101082912  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101083144  SYNPO; synaptopodin isoform X1 [KO:K21112]
101083594  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
101083726  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101084011  RHOA; transforming protein RhoA [KO:K04513]
101084048  CLDN17; claudin-17 [KO:K06087]
101084051  DLG1; disks large homolog 1 isoform X4 [KO:K12076]
101084083  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101084410  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101084469  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
101084672  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
101084688  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
101084765  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101084898  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
101084954  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X5 [KO:K08018]
101085024  STK11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
101085134  [KO:K07839]
101085167  MARVELD3; MARVEL domain-containing protein 3 isoform X2 [KO:K21099]
101085214  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X3 [KO:K10591] [EC:2.3.2.26]
101085247  [KO:K12757]
101085547  CLDN20; claudin-20 [KO:K06087]
101085611  RAP2C; ras-related protein Rap-2c isoform X2 [KO:K07839]
101085658  AMOTL1; angiomotin-like protein 1 isoform X2 [KO:K06104]
101085837  [KO:K12757]
101085911  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
101086093  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X3 [KO:K04354]
101086140  GATA4; transcription factor GATA-4 isoform X2 [KO:K09183]
101086593  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
101086744  CLDN11; claudin-11 [KO:K06087]
101086763  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
101086887  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
101086891  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
101087000  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
101087196  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X2 [KO:K12791]
101087419  ACTR3; actin-related protein 3 [KO:K18584]
101087482  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
101087556  CLDN34; claudin-34 [KO:K06087]
101087729  ACTR2; actin-related protein 2 isoform X2 [KO:K17260]
101087787  NF2; merlin isoform X3 [KO:K16684]
101087851  PRKCZ; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
101087918  [KO:K06087]
101088194  [KO:K05756]
101088205  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
101088207  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
101088369  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X15 [KO:K13305] [EC:2.3.2.26]
101088394  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X8 [KO:K04851]
101088615  CTTN; src substrate cortactin isoform X1 [KO:K06106]
101088910  DLG3; disks large homolog 3 isoform X5 [KO:K21098]
101089314  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
101089577  OCLN; occludin [KO:K06088]
101089905  EPB41L4B; band 4.1-like protein 4B isoform X7 [KO:K21111]
101090328  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
101090494  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
101090556  [KO:K07374]
101090715  RDX; radixin isoform X2 [KO:K05762]
101090774  RAB8B; ras-related protein Rab-8B isoform X3 [KO:K07902]
101090946  PALS1; protein PALS1 [KO:K06091]
101091197  BVES; blood vessel epicardial substance isoform X1 [KO:K21108]
101091236  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
101091310  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101091784  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354]
101092000  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
101092204  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X3 [KO:K07200]
101092284  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X3 [KO:K07199]
101092519  EZR; ezrin isoform X1 [KO:K08007]
101092552  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
101092668  RAB8A; ras-related protein Rab-8A [KO:K07901]
101092974  SYMPK; symplekin isoform X1 [KO:K06100]
101093077  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
101093412  CLDN4; claudin-4 [KO:K06087]
101093785  MYH9; myosin-9 [KO:K10352]
101093797  CLDN18; claudin-18 [KO:K06087]
101093875  CLDN19; claudin-19 [KO:K06087]
101093978  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
101094051  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
101094369  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
101094501  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
101094530  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
101094619  CLDN1; claudin-1 [KO:K06087]
101094667  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101094684  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X2 [KO:K07200]
101094772  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101094805  VASP; vasodilator-stimulated phosphoprotein isoform X3 [KO:K06274]
101094942  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
101095096  [KO:K06087]
101095157  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101095277  TUBA4A; tubulin alpha-4A chain isoform X2 [KO:K07374]
101095353  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101095690  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
101095721  WAS; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
101095885  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X3 [KO:K07198] [EC:2.7.11.31]
101095991  MYL6B; myosin light chain 6B [KO:K12751]
101096000  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
101096019  CLDN7; claudin-7 [KO:K06087]
101096244  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
101096402  [KO:K07374]
101096533  CLDN10; claudin-10 isoform X2 [KO:K06087]
101096706  AMOT; angiomotin [KO:K16819]
101096902  TUBA1A; tubulin alpha-1A chain [KO:K07374]
101096909  CLDN8; claudin-8 [KO:K06087]
101097016  JAM3; junctional adhesion molecule C isoform X2 [KO:K06785]
101097261  JUN; transcription factor AP-1 [KO:K04448]
101097513  CLDN25; putative claudin-25 [KO:K06087]
101097648  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
101097693  MYH11; myosin-11 isoform X1 [KO:K10352]
101097753  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
101097784  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
101097882  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
101097903  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
101097912  DLG2; disks large homolog 2 isoform X18 [KO:K12075]
101097986  ACTN1; alpha-actinin-1 isoform X6 [KO:K05699]
101098036  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
101098507  ACTB; actin, cytoplasmic 1 [KO:K05692]
101098516  [KO:K06448]
101098659  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
101098731  PATJ; inaD-like protein isoform X2 [KO:K06092]
101098769  [KO:K06448]
101098780  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
101099268  [KO:K07374]
101099271  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
101099272  [KO:K06448]
101099546  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
101099674  MYH14; LOW QUALITY PROTEIN: myosin-14 [KO:K10352]
101099931  RAB13; ras-related protein Rab-13 isoform X1 [KO:K06109]
101100119  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
101100223  PARD3; partitioning defective 3 homolog isoform X8 [KO:K04237]
101100378  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101100433  CLDN6; claudin-6 isoform X3 [KO:K06087]
101100607  LLGL2; LLGL scribble cell polarity complex component 2 isoform X4 [KO:K06094]
101100784  CD1D; antigen-presenting glycoprotein CD1d [KO:K06448]
101100907  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
101100958  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
101100990  CGN; cingulin isoform X1 [KO:K06102]
101101169  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101101277  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101101392  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
101101463  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101101605  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
102899726  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
105259666  [KO:K06448]
105260178  [KO:K06448]
105260211  [KO:K06099]
105260214  [KO:K06099]
105260243  [KO:K06099]
105261071  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
105261291  CLDN3; claudin-3 [KO:K06087]
109493927  CRB3; protein crumbs homolog 3 [KO:K06090]
111559184  [KO:K06099]
111559185  [KO:K06099]
111560101  CLDN23; claudin-23 [KO:K06087]
123383365  [KO:K06099]
492308  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
653015  F11R; junctional adhesion molecule A precursor [KO:K06089]
751821  ITGB1; integrin beta-1 precursor [KO:K05719]
751824  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
fca04520  Adherens junction
fca04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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