KEGG   PATHWAY: fch04350
Entry
fch04350                    Pathway                                
Name
TGF-beta signaling pathway - Falco cherrug (Saker falcon)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
fch04350  TGF-beta signaling pathway
fch04350

Other DBs
GO: 0007179
Organism
Falco cherrug (Saker falcon) [GN:fch]
Gene
102045725  FMOD; fibromodulin [KO:K08121]
102045802  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
102045945  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
102045996  BMP7; bone morphogenetic protein 7 [KO:K16621]
102046018  ACVR1B; LOW QUALITY PROTEIN: activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
102046372  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
102046415  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
102046473  SP1; transcription factor Sp1 isoform X3 [KO:K04684]
102046476  NRROS; transforming growth factor beta activator LRRC33 [KO:K26317]
102047171  BMP4; bone morphogenetic protein 4 isoform X2 [KO:K04662]
102047345  NODAL; nodal homolog [KO:K04666]
102047515  [KO:K14736]
102047526  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
102047584  LEFTY1; left-right determination factor 1 [KO:K04668]
102047602  SMAD9; mothers against decapentaplegic homolog 9 isoform X1 [KO:K16791]
102047640  [KO:K26316]
102047662  IFNG; interferon gamma [KO:K04687]
102047778  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
102047809  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
102048221  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102048236  [KO:K04501]
102048415  GREM2; gremlin-2 [KO:K23318]
102048434  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
102048541  TFDP1; transcription factor Dp-1 isoform X2 [KO:K04683]
102048632  [KO:K04388] [EC:2.7.11.30]
102048793  BMP2; bone morphogenetic protein 2 [KO:K21283]
102048917  PITX2; pituitary homeobox 2 [KO:K04686]
102049025  TFRC; transferrin receptor protein 1 isoform X2 [KO:K06503]
102049106  GDF5; growth/differentiation factor 5 [KO:K04664]
102049116  TMEM53; transmembrane protein 53 [KO:K28359]
102049121  LTBP1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
102049129  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
102049160  RHOA; transforming protein RhoA [KO:K04513]
102050265  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
102050359  [KO:K19558]
102050634  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
102050671  [KO:K21283]
102050853  CHRD; chordin [KO:K04657]
102050985  GDF7; LOW QUALITY PROTEIN: growth/differentiation factor 7 [KO:K20013]
102051174  INHBB; LOW QUALITY PROTEIN: inhibin beta B chain [KO:K22687]
102051205  HJV; hemojuvelin [KO:K23100]
102051298  TGIF2; homeobox protein TGIF2 [KO:K19553]
102051402  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
102051422  TGIF1; homeobox protein TGIF1 isoform X1 [KO:K19383]
102052198  NEO1; neogenin isoform X1 [KO:K06766]
102052286  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
102052550  ZFYVE9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
102052578  [KO:K16622]
102052607  LRRC32; transforming growth factor beta activator LRRC32 isoform X2 [KO:K26316]
102052673  LEMD3; inner nuclear membrane protein Man1 [KO:K19410]
102052691  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
102052757  [KO:K22688]
102052925  AMH; muellerian-inhibiting factor [KO:K04665]
102052930  [KO:K22688]
102052989  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102053092  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
102053325  ACVR2A; activin receptor type-2A isoform X2 [KO:K04670] [EC:2.7.11.30]
102053489  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
102053568  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
102053572  THSD4; thrombospondin type-1 domain-containing protein 4 [KO:K23377]
102053703  SKIL; ski-like protein [KO:K18499]
102053724  GDF6; growth/differentiation factor 6 [KO:K20012]
102054291  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
102054641  FST; follistatin isoform X1 [KO:K04661]
102054866  THBS1; thrombospondin-1 [KO:K16857]
102054930  GREM1; gremlin-1 [KO:K23318]
102055038  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
102055307  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
102055405  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
102055453  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102055666  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
102056187  CUL1; cullin-1 [KO:K03347]
102056197  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102056653  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
102056711  [KO:K06825]
102056819  BMP6; bone morphogenetic protein 6 [KO:K16620]
102056832  MYC; myc proto-oncogene protein [KO:K04377]
102057067  E2F4; LOW QUALITY PROTEIN: transcription factor E2F4 [KO:K04682]
102057203  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
102057325  E2F5; transcription factor E2F5 [KO:K04682]
102057525  NOG; noggin [KO:K04658]
102057732  SKI; ski oncogene [KO:K26503]
102057734  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
102057852  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
102057965  SMAD6; mothers against decapentaplegic homolog 6 [KO:K04677]
102057985  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
102058012  RGMB; RGM domain family member B [KO:K06847]
102058179  INHBA; inhibin beta A chain [KO:K04667]
102058345  DCN; decorin [KO:K04660]
102058381  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102058528  ID3; DNA-binding protein inhibitor ID-3 [KO:K17694]
102058768  SMAD7; mothers against decapentaplegic homolog 7 isoform X2 [KO:K19631]
102058899  SMAD5; mothers against decapentaplegic homolog 5 [KO:K16790]
102059397  RGMA; repulsive guidance molecule A [KO:K23096]
102059402  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
102059410  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
102060271  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
106630822  [KO:K04677]
106631726  [KO:K21283]
114017027  [KO:K28359]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
fch04010  MAPK signaling pathway
fch04110  Cell cycle
fch04120  Ubiquitin mediated proteolysis
fch04210  Apoptosis
KO pathway
ko04350   

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