KEGG   PATHWAY: fch04010
Entry
fch04010                    Pathway                                
Name
MAPK signaling pathway - Falco cherrug (Saker falcon)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
fch04010  MAPK signaling pathway
fch04010

Other DBs
GO: 0000165
Organism
Falco cherrug (Saker falcon) [GN:fch]
Gene
102045852  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
102045898  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102046056  KITLG; kit ligand [KO:K05461]
102046128  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102046148  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
102046190  RASA1; ras GTPase-activating protein 1 [KO:K04352]
102046230  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102046341  [KO:K04853]
102046374  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
102046471  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
102046627  [KO:K09253]
102046644  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
102046664  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
102046752  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102046809  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
102046818  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102046877  FGF20; fibroblast growth factor 20 [KO:K04358]
102046942  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
102046964  SRF; serum response factor isoform X2 [KO:K04378]
102047148  MRAS; ras-related protein M-Ras [KO:K07831]
102047196  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
102047271  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102047307  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X3 [KO:K04430] [EC:2.7.12.2]
102047370  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102047380  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102047392  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
102047513  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
102047564  EFNA3; ephrin-A3 [KO:K05462]
102047711  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
102047715  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
102047778  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
102047801  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
102047898  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X2 [KO:K04444] [EC:2.7.11.1]
102047995  RAP1B; ras-related protein Rap-1b [KO:K07836]
102048020  PDGFC; platelet-derived growth factor C [KO:K05450]
102048037  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
102048069  [KO:K04431] [EC:2.7.12.2]
102048122  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102048150  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
102048177  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
102048221  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102048432  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
102048492  CRK; adapter molecule crk [KO:K04438]
102048502  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102048544  NF1; neurofibromin isoform X2 [KO:K08052]
102048630  MAP3K14; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102048632  [KO:K04388] [EC:2.7.11.30]
102048640  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
102048724  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
102048986  STMN1; stathmin [KO:K04381]
102049097  GDNF; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
102049265  EGF; pro-epidermal growth factor [KO:K04357]
102049292  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
102049324  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102049336  [KO:K04873]
102049350  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102049415  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
102049462  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102049511  [KO:K19663] [EC:2.7.11.13]
102049695  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102049706  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
102049917  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
102049937  [KO:K04870]
102049997  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
102049998  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
102050007  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102050090  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
102050094  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102050112  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
102050179  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
102050180  MEF2C; myocyte-specific enhancer factor 2C isoform X3 [KO:K04454]
102050206  RPS6KA1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
102050349  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
102050351  [KO:K04421] [EC:2.7.11.25]
102050406  JUN; transcription factor AP-1 [KO:K04448]
102050412  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
102050449  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102050648  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
102050700  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
102050734  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
102050745  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
102050770  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
102050776  [KO:K04519]
102050830  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X3 [KO:K04443] [EC:2.7.11.1]
102051164  CRKL; crk-like protein [KO:K04438]
102051166  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102051197  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102051326  MAP3K20; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
102051357  [KO:K04465]
102051492  [KO:K05096] [EC:2.7.10.1]
102051498  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
102051503  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102051874  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102051939  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102052010  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
102052019  KRAS; GTPase KRas isoform X1 [KO:K07827]
102052038  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102052148  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
102052167  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102052175  STK3; serine/threonine-protein kinase 3 [KO:K04412]
102052181  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X7 [KO:K04863]
102052225  ANGPT4; angiopoietin-4 [KO:K05467]
102052231  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102052235  ANGPT1; angiopoietin-1 [KO:K05465]
102052236  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
102052252  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
102052290  PDGFD; platelet-derived growth factor D [KO:K05450]
102052421  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
102052422  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102052668  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X3 [KO:K04420] [EC:2.7.11.25]
102052683  NTF3; neurotrophin-3 [KO:K04356]
102052703  MAP2K3; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102052718  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102052727  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102052736  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102052801  RAP1A; ras-related protein Rap-1A [KO:K04353]
102052861  FGF3; fibroblast growth factor 3 [KO:K04358]
102052893  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102052999  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
102053069  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102053077  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102053088  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102053134  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102053161  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
102053337  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
102053397  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102053489  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
102053491  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2 [KO:K04467] [EC:2.7.11.10]
102053577  VEGFA; vascular endothelial growth factor A [KO:K05448]
102053583  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102053617  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
102053620  CDC25B; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
102053727  FGF23; fibroblast growth factor 23 [KO:K22428]
102053756  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102053809  [KO:K16342] [EC:3.1.1.4]
102053816  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102053857  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
102053900  FGF6; fibroblast growth factor 6 [KO:K04358]
102053905  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
102053931  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
102053945  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102053985  [KO:K16342] [EC:3.1.1.4]
102053987  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102054020  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
102054155  [KO:K16342] [EC:3.1.1.4]
102054176  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102054190  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
102054191  CACNB4; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
102054310  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102054322  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102054359  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102054509  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
102054561  FGF2; fibroblast growth factor 2 [KO:K18497]
102054590  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
102054682  [KO:K16342] [EC:3.1.1.4]
102054748  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
102054833  EFNA2; ephrin-A2 [KO:K05462]
102054933  MAP4K4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
102054942  NRAS; GTPase NRas [KO:K07828]
102054961  INS; LOW QUALITY PROTEIN: insulin [KO:K04526]
102055038  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
102055141  MECOM; MDS1 and EVI1 complex locus protein isoform X1 [KO:K04462] [EC:2.1.1.367]
102055369  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102055419  FGF8; fibroblast growth factor 8 [KO:K04358]
102055424  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102055425  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102055434  STK4; serine/threonine-protein kinase 4 [KO:K04411]
102055449  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
102055453  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102055464  FGF19; fibroblast growth factor 19 [KO:K22603]
102055493  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
102055506  HRAS; GTPase HRas [KO:K02833]
102055621  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
102055637  NGF; beta-nerve growth factor [KO:K02582]
102055660  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
102055682  FGF9; fibroblast growth factor 9 [KO:K04358]
102055757  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
102055811  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102055826  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
102055830  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
102055848  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
102056102  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102056125  ARRB1; beta-arrestin-1 [KO:K04439]
102056167  FGF10; fibroblast growth factor 10 [KO:K04358]
102056178  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102056291  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102056397  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102056424  SOS2; son of sevenless homolog 2 [KO:K03099]
102056440  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
102056519  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
102056537  [KO:K05084] [EC:2.7.10.1]
102056607  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X2 [KO:K18018] [EC:3.1.3.48]
102056832  MYC; myc proto-oncogene protein [KO:K04377]
102056938  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
102056981  CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453]
102057038  MAP3K5; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102057058  TGFA; protransforming growth factor alpha [KO:K08774]
102057094  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
102057209  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102057224  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102057239  HSPB1; heat shock protein beta-1 [KO:K04455]
102057301  [KO:K16342] [EC:3.1.1.4]
102057320  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102057404  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
102057421  FGF18; fibroblast growth factor 18 [KO:K04358]
102057449  FGF16; fibroblast growth factor 16 [KO:K04358]
102057470  [KO:K16342] [EC:3.1.1.4]
102057575  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102057621  EREG; proepiregulin [KO:K09784]
102057637  [KO:K16342] [EC:3.1.1.4]
102057742  IGF2; insulin-like growth factor II [KO:K13769]
102057791  AREG; amphiregulin [KO:K09782]
102057797  EFNA5; ephrin-A5 [KO:K05462]
102057894  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102057901  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102057922  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
102057932  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102058044  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
102058109  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
102058143  DUSP4; LOW QUALITY PROTEIN: dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102058184  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X11 [KO:K04857]
102058219  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
102058267  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
102058334  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
102058347  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
102058428  PPM1A; protein phosphatase 1A isoform X5 [KO:K04457] [EC:3.1.3.16]
102058475  FGF5; fibroblast growth factor 5 [KO:K04358]
102058683  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102058694  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X2 [KO:K18019] [EC:3.1.3.48]
102058816  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102058825  NRTN; neurturin [KO:K25414]
102058892  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102058936  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
102059010  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
102059103  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
102059179  MAX; protein max isoform X2 [KO:K04453]
102059263  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102059307  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X9 [KO:K04858]
102059377  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102059520  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102059866  [KO:K04373] [EC:2.7.11.1]
102059920  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
102059926  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
102059957  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
102059983  PGF; placenta growth factor [KO:K16859]
102060018  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102060062  IGF1; insulin-like growth factor I [KO:K05459]
102060113  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
102060155  [KO:K04386]
102060194  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X9 [KO:K08018]
102060232  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102060261  VEGFD; vascular endothelial growth factor D [KO:K05449]
106631501  FGF22; fibroblast growth factor 22 [KO:K04358]
114017812  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
fch04070  Phosphatidylinositol signaling system
fch04110  Cell cycle
fch04115  p53 signaling pathway
fch04210  Apoptosis
fch04310  Wnt signaling pathway
KO pathway
ko04010   

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