KEGG   PATHWAY: gfr04150
Entry
gfr04150                    Pathway                                
Name
mTOR signaling pathway - Geospiza fortis (medium ground-finch)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
gfr04150  mTOR signaling pathway
gfr04150

Organism
Geospiza fortis (medium ground-finch) [GN:gfr]
Gene
102035013  SLC7A5; solute carrier family 7 member 5 [KO:K13780]
102045065  SLC38A9; solute carrier family 38 member 9 [KO:K14995]
102038391  ATP6V1A; ATPase H+ transporting V1 subunit A [KO:K02145] [EC:7.1.2.2]
102037079  ATP6V1B2; V-type proton ATPase subunit B [KO:K02147]
102038205  ATP6V1B1; ATPase H+ transporting V1 subunit B1 [KO:K02147]
102036816  ATP6V1C1; ATPase H+ transporting V1 subunit C1 [KO:K02148]
102033157  ATP6V1C2; ATPase H+ transporting V1 subunit C2 [KO:K02148]
102032589  ATP6V1D; ATPase H+ transporting V1 subunit D [KO:K02149]
102032230  ATP6V1E1; ATPase H+ transporting V1 subunit E1 [KO:K02150]
102035397  ATP6V1G3; ATPase H+ transporting V1 subunit G3 [KO:K02152]
102043965  ATP6V1G1; ATPase H+ transporting V1 subunit G1 [KO:K02152]
102031430  ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
102036612  LAMTOR2; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 [KO:K20398]
102037306  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
102031736  LAMTOR5; late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 [KO:K16344]
102041065  FLCN; folliculin [KO:K09594]
102037932  FNIP1; folliculin interacting protein 1 [KO:K20400]
102042273  FNIP2; folliculin interacting protein 2 [KO:K20401]
102031852  RRAGA; ras-related GTP-binding protein A [KO:K16185]
102038900  RRAGD; Ras related GTP binding D [KO:K16186]
102041314  RRAGC; Ras related GTP binding C [KO:K16186]
102037166  SESN2; sestrin-2 [KO:K20394]
102032956  GATSL2; GATS protein like 2 [KO:K23081]
102031823  MIOS; meiosis regulator for oocyte development [KO:K20407]
102033385  SEH1L; SEH1 like nucleoporin [KO:K14299]
102040278  WDR24; WD repeat domain 24 [KO:K20408]
102043470  WDR59; WD repeat domain 59 [KO:K20409]
102036100  SEC13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
102034888  DEPDC5; DEP domain containing 5 [KO:K20404]
102044397  NPRL2; NPR2-like, GATOR1 complex subunit [KO:K20405]
102034685  NPRL3; NPR3 like, GATOR1 complex subunit [KO:K20406]
102037500  SKP2; S-phase kinase associated protein 2 [KO:K03875]
102045189  RNF152; ring finger protein 152 [KO:K15705] [EC:2.3.2.27]
102035893  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
102034190  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102044854  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
102044896  DEPTOR; DEP domain containing MTOR interacting protein [KO:K20402]
102040566  MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
102035871  TELO2; telomere maintenance 2 [KO:K11137]
102040377  TTI1; TELO2 interacting protein 1 [KO:K20403]
102031726  CLIP1; CAP-Gly domain containing linker protein 1 [KO:K10421]
102033131  GRB10; growth factor receptor bound protein 10 [KO:K20064]
102039226  LPIN2; lipin 2 [KO:K15728] [EC:3.1.3.4]
102032547  LPIN3; lipin 3 [KO:K15728] [EC:3.1.3.4]
102032497  LPIN1; lipin 1 [KO:K15728] [EC:3.1.3.4]
102038562  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
102038744  ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
102038549  EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
102040652  EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
102045616  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
102036821  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102034545  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
102032769  RPS6; ribosomal protein S6 [KO:K02991]
102031857  STRADA; STE20-related kinase adaptor alpha [KO:K08271]
102044106  STRADB; STE20-related kinase adaptor beta [KO:K17532]
102045531  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
102043462  CAB39L; calcium binding protein 39 like [KO:K08272]
102041350  CAB39; calcium binding protein 39 [KO:K08272]
102044941  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
102038682  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
102031783  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
102040493  TSC1; tuberous sclerosis 1 [KO:K07206]
102039715  TSC2; tuberous sclerosis 2 [KO:K07207]
102036869  TBC1D7; TBC1 domain family member 7 [KO:K20396]
102045581  RHEB; Ras homolog enriched in brain [KO:K07208]
102033698  WNT1; Wnt family member 1 [KO:K03209]
102040836  WNT2; Wnt family member 2 [KO:K00182]
102039793  WNT2B; Wnt family member 2B [KO:K00182]
102042820  WNT3A; Wnt family member 3A [KO:K00312]
102040466  WNT3; Wnt family member 3 [KO:K00312]
106631805  protein Wnt-4-like [KO:K00408]
102040060  WNT4; Wnt family member 4 [KO:K00408]
102037267  WNT5A; Wnt family member 5A [KO:K00444]
102035335  WNT5B; Wnt family member 5B [KO:K00444]
102035490  WNT6; Wnt family member 6 [KO:K00445]
102044794  WNT7B; Wnt family member 7B [KO:K00572]
102043987  WNT7A; Wnt family member 7A [KO:K00572]
102039167  WNT8B; Wnt family member 8B [KO:K00714]
102042115  WNT8A; Wnt family member 8A [KO:K00714]
102036952  WNT9A; Wnt family member 9A [KO:K01064]
102040292  WNT9B; Wnt family member 9B [KO:K01064]
102035663  WNT10A; Wnt family member 10A [KO:K01357]
102037571  protein Wnt-11b-like [KO:K01384]
102036206  WNT11; Wnt family member 11 [KO:K01384]
102041852  WNT16; Wnt family member 16 [KO:K01558]
102033704  FZD7; frizzled class receptor 7 [KO:K02432]
102044783  FZD1; frizzled class receptor 1 [KO:K02432]
102043157  frizzled-2 [KO:K02235]
102043328  frizzled-2-like [KO:K02235]
102041877  FZD3; frizzled class receptor 3 [KO:K02329]
102036074  FZD4; frizzled class receptor 4 [KO:K02354]
102033033  FZD5; frizzled class receptor 5 [KO:K02375]
102036992  FZD6; frizzled class receptor 6 [KO:K02376]
102040561  FZD10; frizzled class receptor 10 [KO:K02842]
102034797  FZD9; frizzled class receptor 9 [KO:K02842]
102045063  LRP6; LDL receptor related protein 6 [KO:K03068]
102043682  LRP5; LDL receptor related protein 5 [KO:K03068]
102039062  DVL3; dishevelled segment polarity protein 3 [KO:K02353]
102042753  DVL1; dishevelled segment polarity protein 1 [KO:K02353]
102034944  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102036131  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102035648  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102044590  INS; insulin [KO:K04526]
102032215  IGF1; insulin like growth factor 1 [KO:K05459]
102036061  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102036037  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102038068  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102038427  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102033314  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102044012  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102035876  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102039955  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102032961  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102034977  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102031727  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102041148  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102043401  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102044170  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
102035007  RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
102034354  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
102038515  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
102044407  IRS1; insulin receptor substrate 1 [KO:K16172]
102039817  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102032353  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102035891  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102042284  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102040845  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102040853  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102039901  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102032960  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102036745  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102036791  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102042264  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102033267  MAPKAP1; mitogen-activated protein kinase associated protein 1 [KO:K20410]
102035806  RICTOR; RPTOR independent companion of MTOR complex 2 [KO:K08267]
102036495  PRR5; proline rich 5 [KO:K20411]
102040366  PRR5L; proline rich 5 like [KO:K20411]
102034459  RHOA; ras homolog family member A [KO:K04513]
102043485  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102041922  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102040754  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
102037330  SGK1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
gfr00561  Glycerolipid metabolism
gfr04010  MAPK signaling pathway
gfr04140  Autophagy - animal
gfr04810  Regulation of actin cytoskeleton
gfr04910  Insulin signaling pathway
KO pathway
ko04150   
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