KEGG   PATHWAY: gfr04810
Entry
gfr04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Geospiza fortis (medium ground-finch)
Class
Cellular Processes; Cell motility
Pathway map
gfr04810  Regulation of actin cytoskeleton
gfr04810

Other DBs
GO: 0030036
Organism
Geospiza fortis (medium ground-finch) [GN:gfr]
Gene
102038748  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
102032612  lysophosphatidic acid receptor 1-like [KO:K04289]
102032251  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102036590  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102041046  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102033194  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
102040756  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
102034334  F2; coagulation factor II, thrombin [KO:K01313] [EC:3.4.21.5]
102045591  F2R; coagulation factor II thrombin receptor [KO:K03914]
102044590  INS; insulin [KO:K04526]
102034269  EGF; epidermal growth factor [KO:K04357]
102031991  FGF1; fibroblast growth factor 1 [KO:K18496]
102035880  FGF2; fibroblast growth factor 2 [KO:K18497]
102044043  FGF20; fibroblast growth factor 20 [KO:K04358]
102039340  FGF8; fibroblast growth factor 8 [KO:K04358]
102039970  FGF9; fibroblast growth factor 9 [KO:K04358]
102032503  FGF10; fibroblast growth factor 10 [KO:K04358]
102039574  FGF5; fibroblast growth factor 5 [KO:K04358]
102036865  FGF7; fibroblast growth factor 7 [KO:K04358]
102033173  FGF3; fibroblast growth factor 3 [KO:K04358]
102033341  FGF4; fibroblast growth factor 4 [KO:K04358]
102045202  FGF18; fibroblast growth factor 18 [KO:K04358]
102034856  FGF6; fibroblast growth factor 6 [KO:K04358]
102033508  FGF19; fibroblast growth factor 19 [KO:K22603]
102038755  FGF23; fibroblast growth factor 23 [KO:K22428]
102032936  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102036985  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102035549  PDGFC; platelet derived growth factor C [KO:K05450]
102044886  PDGFD; platelet derived growth factor D [KO:K05450]
102039559  INSRR; insulin receptor related receptor [KO:K05086] [EC:2.7.10.1]
102045482  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102033908  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102038840  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102044988  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102044508  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102044274  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102045343  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102039500  FN1; fibronectin 1 [KO:K05717]
102032334  ITGA1; integrin subunit alpha 1 [KO:K06480]
102038455  ITGA2; integrin subunit alpha 2 [KO:K06481]
102036678  ITGA3; integrin subunit alpha 3 [KO:K06482]
102045380  ITGA4; integrin subunit alpha 4 [KO:K06483]
102042715  ITGA6; integrin subunit alpha 6 [KO:K06485]
102032097  ITGA8; integrin subunit alpha 8 [KO:K06584]
102032026  ITGA9; integrin subunit alpha 9 [KO:K06585]
102033726  ITGA11; integrin subunit alpha 11 [KO:K06587]
102036333  ITGAV; integrin subunit alpha V [KO:K06487]
102039987  ITGB1; integrin subunit beta 1 [KO:K05719]
102035991  ITGB2; integrin subunit beta 2 [KO:K06464]
102043377  ITGB3; integrin subunit beta 3 [KO:K06493]
102031672  ITGB4; integrin subunit beta 4 [KO:K06525]
102045444  ITGB5; integrin subunit beta 5 [KO:K06588]
102038988  ITGB6; integrin subunit beta 6 [KO:K06589]
102035625  ITGB8; integrin subunit beta 8 [KO:K06591]
102032656  KNG1; kininogen 1 [KO:K03898]
102042552  BDKRB1; bradykinin receptor B1 [KO:K03915]
102042390  BDKRB2; bradykinin receptor B2 [KO:K03916]
102032522  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
102034461  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
102033258  CHRM4; cholinergic receptor muscarinic 4 [KO:K04132]
102040192  CHRM5; cholinergic receptor muscarinic 5 [KO:K04133]
102039071  C5; complement C5 [KO:K03994]
102039194  C6; complement C6 [KO:K03995]
102039022  C7; complement C7 [KO:K03996]
102038403  C8A; complement C8 alpha chain [KO:K03997]
102032114  C8B; complement C8 beta chain [KO:K03998]
102035983  C9; complement C9 [KO:K04000]
102044790  GNA12; G protein subunit alpha 12 [KO:K04346]
102040291  GNA13; G protein subunit alpha 13 [KO:K04639]
102042757  GNG12; G protein subunit gamma 12 [KO:K04347]
102042260  FGD3; FYVE, RhoGEF and PH domain containing 3 [KO:K05722]
102043366  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
102041223  BCAR1; BCAR1, Cas family scaffolding protein [KO:K05726]
102039553  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
102040219  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
102031457  DOCK1; dedicator of cytokinesis 1 [KO:K13708]
102044186  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
102038427  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102033314  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102044012  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102035876  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102039955  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102033064  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
102033145  MRAS; muscle RAS oncogene homolog [KO:K07831]
102032220  ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor 6 [KO:K05729]
102042284  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102040845  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102040853  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102039817  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102032353  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102035891  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102042626  VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
102040520  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
102032961  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102034977  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102032653  MOS; MOS proto-oncogene, serine/threonine kinase [KO:K04367] [EC:2.7.11.1]
102031727  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102041148  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102043401  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102036745  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102036791  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102044369  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
102031981  ARHGAP35; Rho GTPase activating protein 35 [KO:K05732]
102034459  RHOA; ras homolog family member A [KO:K04513]
102035279  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102031835  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102043334  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102036055  CDC42; cell division cycle 42 [KO:K04393]
102033628  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102034742  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
102042620  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
102033882  serine/threonine-protein kinase PAK 1-like [KO:K05733] [EC:2.7.11.1]
102045516  PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
102033561  PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
102035218  ARHGEF7; Rho guanine nucleotide exchange factor 7 [KO:K13710]
102040220  GIT1; GIT ArfGAP 1 [KO:K05737]
102040824  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
102032829  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102037734  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
102037824  MYLK2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18]
102038683  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
102044716  MYLK; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
102032151  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
102042078  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
102039437  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102037308  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
102044251  protein phosphatase 1 regulatory subunit 12B-like [KO:K12329]
102032391  MYL2; myosin light chain 2 [KO:K10351]
102045323  MYL9; myosin light chain 9 [KO:K12755]
102034903  MYL10; myosin light chain 10 [KO:K12756]
102038378  MYL12B; myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
102037536  MYH11; myosin heavy chain 11 [KO:K10352]
102040737  MYH10; myosin heavy chain 10 [KO:K10352]
102044062  MYH9; myosin heavy chain 9 [KO:K10352]
102039602  DIAPH2; diaphanous related formin 2 [KO:K05741]
102032850  SLC9A1; solute carrier family 9 member A1 [KO:K05742]
102041792  PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
102040285  PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
102038093  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
102040087  PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149]
102044998  PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149]
102039163  PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
102036824  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
102032107  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
102042315  DIAPH3; diaphanous related formin 3 [KO:K05745]
102036334  BAIAP2; BAI1 associated protein 2 [KO:K05627]
102044360  ENAH; enabled homolog (Drosophila) [KO:K05746]
102042679  WASL; Wiskott-Aldrich syndrome like [KO:K23612]
102032350  WASF2; WAS protein family member 2 [KO:K05748]
102036924  CYFIP2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
102035859  CYFIP1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
102038198  NCKAP1; NCK associated protein 1 [KO:K05750]
102040017  ABI2; abl interactor 2 [KO:K05751]
102036578  WASF1; WAS protein family member 1 [KO:K05753]
102033338  ACTR2; ARP2 actin related protein 2 homolog [KO:K17260]
102042606  ACTR3; ARP3 actin related protein 3 homolog [KO:K18584]
102043245  ACTR3B; ARP3 actin related protein 3 homolog B [KO:K18584]
102040769  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
102043621  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
102035099  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
102044025  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
102038793  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
102043209  actin, cytoplasmic type 5 [KO:K05692]
102041442  ACTB; actin beta [KO:K05692]
102036125  PFN2; profilin 2 [KO:K05759]
102044963  PXN; paxillin [KO:K05760]
102044183  EZR; ezrin [KO:K08007]
102042609  RDX; radixin [KO:K05762]
102034534  MSN; moesin [KO:K05763]
102043761  TMSB4X; thymosin beta 4, X-linked [KO:K05764]
102041951  thymosin beta-12-like [KO:K05764]
102035905  CFL2; cofilin 2 [KO:K05765]
102034120  SSH1; slingshot protein phosphatase 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102040565  SSH2; slingshot protein phosphatase 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102037591  VCL; vinculin [KO:K05700]
102042572  IQGAP1; IQ motif containing GTPase activating protein 1 [KO:K16848]
102031406  IQGAP2; IQ motif containing GTPase activating protein 2 [KO:K05767]
102035941  IQGAP3; IQ motif containing GTPase activating protein 3 [KO:K05767]
102035914  GSN; gelsolin [KO:K05768]
102041266  SCIN; scinderin [KO:K05768]
102042336  ACTN1; actinin alpha 1 [KO:K05699]
102033981  alpha-actinin-4-like [KO:K05699]
102038857  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
102041365  APC; APC, WNT signaling pathway regulator [KO:K02085]
102043587  ARHGEF4; Rho guanine nucleotide exchange factor 4 [KO:K05769]
102039118  SPATA13; spermatogenesis associated 13 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
gfr04010  MAPK signaling pathway
gfr04510  Focal adhesion
gfr04520  Adherens junction
KO pathway
ko04810   
LinkDB

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