KEGG   PATHWAY: hgl00564
Entry
hgl00564                    Pathway                                
Name
Glycerophospholipid metabolism - Heterocephalus glaber (naked mole-rat)
Class
Metabolism; Lipid metabolism
Pathway map
hgl00564  Glycerophospholipid metabolism
hgl00564

Module
hgl_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:hgl00564]
hgl_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:hgl00564]
hgl_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:hgl00564]
Other DBs
GO: 0006650
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
101707148  Gpd1l; glycerol-3-phosphate dehydrogenase 1-like [KO:K00006] [EC:1.1.1.8]
101702723  Gpd1; glycerol-3-phosphate dehydrogenase 1 [KO:K00006] [EC:1.1.1.8]
101715967  Gpd2; glycerol-3-phosphate dehydrogenase 2 [KO:K00111] [EC:1.1.5.3]
101701339  Gpat2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
101722717  Gpam; glycerol-3-phosphate acyltransferase, mitochondrial [KO:K00629] [EC:2.3.1.15]
101723615  Gpat3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
101717224  Gpat4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
101706478  Agpat2; 1-acylglycerol-3-phosphate O-acyltransferase 2 [KO:K13509] [EC:2.3.1.51]
101712016  Agpat1; 1-acylglycerol-3-phosphate O-acyltransferase 1 [KO:K13509] [EC:2.3.1.51]
101697430  Agpat3; 1-acylglycerol-3-phosphate O-acyltransferase 3 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101701125  Agpat4; 1-acylglycerol-3-phosphate O-acyltransferase 4 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101712496  Agpat5; 1-acylglycerol-3-phosphate O-acyltransferase 5 [KO:K19007] [EC:2.3.1.51]
101705833  Lclat1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
101699551  Mboat1; membrane bound O-acyltransferase domain containing 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
101705898  Mboat2; membrane bound O-acyltransferase domain containing 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
101712069  Gnpat; glyceronephosphate O-acyltransferase [KO:K00649] [EC:2.3.1.42]
101700336  Adprm; ADP-ribose/CDP-alcohol diphosphatase, manganese dependent [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
101724889  Plpp1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
101725640  Plpp2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
101699454  Plpp3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
101714530  Lpin2; lipin 2 [KO:K15728] [EC:3.1.3.4]
101722006  Lpin3; lipin 3 [KO:K15728] [EC:3.1.3.4]
101721483  Lpin1; lipin 1 [KO:K15728] [EC:3.1.3.4]
101704950  Plpp5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
101712912  Plpp4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
101698068  Dgkh; diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
101726548  Dgkg; diacylglycerol kinase gamma [KO:K00901] [EC:2.7.1.107]
101713287  Dgkb; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
101726134  Dgkq; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
101706860  Dgki; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
101696881  Dgkz; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
101726645  Dgkk; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
101696575  Dgka; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
101708262  Dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
101718894  Dgkd; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
101711138  Chpt1; choline phosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
101721378  Cept1; choline/ethanolamine phosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
101700438  Pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
101713528  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
101698668  Pld4; phospholipase D family member 4 [KO:K16860] [EC:3.1.4.4]
101722231  Pld3; phospholipase D family member 3 [KO:K16860] [EC:3.1.4.4]
101700977  Lcat; lecithin-cholesterol acyltransferase [KO:K00650] [EC:2.3.1.43]
101708051  Pla2g3; phospholipase A2 group III [KO:K01047] [EC:3.1.1.4]
101699902  Pla2g1b; phospholipase A2 group IB [KO:K01047] [EC:3.1.1.4]
101696546  Pla2g10; phospholipase A2 group X [KO:K01047] [EC:3.1.1.4]
101702299  Pla2g12b; phospholipase A2 group XIIB [KO:K01047] [EC:3.1.1.4]
101711308  Pla2g5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
101725417  Pla2g2e; phospholipase A2 group IIE [KO:K01047] [EC:3.1.1.4]
101725805  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
101726523  Pla2g2f; phospholipase A2 group IIF [KO:K01047] [EC:3.1.1.4]
101696389  Pla2g2c; phospholipase A2 group IIC [KO:K01047] [EC:3.1.1.4]
101710939  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
101711672  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
101706727  Pla2g12a; phospholipase A2 group XIIA [KO:K01047] [EC:3.1.1.4]
101705849  Pla2g4e; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
101706202  Pla2g4f; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
101703792  Pla2g4b; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
101717491  Pla2g4d; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
101713091  Pla2g4c; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
101704061  Pla2g4a; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
101710669  Pla2g6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
101699397  Plb1; phospholipase B1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
101712273  Pla2g16; HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101713128  HRAS-like suppressor 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101709594  Lpcat1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
101696607  Lpcat2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
101703809  Lpcat4; lysophosphatidylcholine acyltransferase 4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
101696621  Lpcat3; lysophosphatidylcholine acyltransferase 3 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
101709662  Lypla1; lysophospholipase I [KO:K06128] [EC:3.1.1.5]
101721832  acyl-protein thioesterase 1-like [KO:K06128] [EC:3.1.1.5]
101698711  Pla2g15; phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
101714284  Lypla2; lysophospholipase II [KO:K06130] [EC:3.1.1.5]
101702884  Pnpla7; patatin like phospholipase domain containing 7 [KO:K14676] [EC:3.1.1.5]
101724286  Pnpla6; patatin like phospholipase domain containing 6 [KO:K14676] [EC:3.1.1.5]
101716686  Gpcpd1; glycerophosphocholine phosphodiesterase 1 [KO:K18695] [EC:3.1.4.2]
101711939  Chat; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
101705724  Ache; acetylcholinesterase (Cartwright blood group) [KO:K01049] [EC:3.1.1.7]
101723925  Chkb; choline kinase beta [KO:K14156] [EC:2.7.1.32 2.7.1.82]
101720091  Chka; choline kinase alpha [KO:K14156] [EC:2.7.1.32 2.7.1.82]
101721548  Phospho1; phosphoethanolamine/phosphocholine phosphatase [KO:K06124] [EC:3.1.3.75]
101699942  Pcyt1b; phosphate cytidylyltransferase 1, choline, beta [KO:K00968] [EC:2.7.7.15]
101705565  Pcyt1a; phosphate cytidylyltransferase 1, choline, alpha [KO:K00968] [EC:2.7.7.15]
101696807  Selenoi; selenoprotein I [KO:K00993] [EC:2.7.8.1]
101723803  Etnk1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
101697056  Etnk2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
101715163  Pcyt2; phosphate cytidylyltransferase 2, ethanolamine [KO:K00967] [EC:2.7.7.14]
101708633  Etnppl; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
101706125  Pemt; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
101714337  Cds2; CDP-diacylglycerol synthase 2 [KO:K00981] [EC:2.7.7.41]
101726280  Cds1; CDP-diacylglycerol synthase 1 [KO:K00981] [EC:2.7.7.41]
101703405  Pla1a; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
101708774  Ptdss1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
101716975  Ptdss2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
101703801  Pisd; phosphatidylserine decarboxylase [KO:K01613] [EC:4.1.1.65]
101704870  Pgs1; phosphatidylglycerophosphate synthase 1 [KO:K00995] [EC:2.7.8.5]
101720146  Crls1; cardiolipin synthase 1 [KO:K08744] [EC:2.7.8.41]
101704009  Taz; tafazzin [KO:K13511] [EC:2.3.1.-]
101707603  Lpgat1; lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
101714318  Cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
101723338  Mboat7; membrane bound O-acyltransferase domain containing 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
hgl00010  Glycolysis / Gluconeogenesis
hgl00260  Glycine, serine and threonine metabolism
hgl00561  Glycerolipid metabolism
hgl00562  Inositol phosphate metabolism
hgl00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
hgl00565  Ether lipid metabolism
hgl00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

DBGET integrated database retrieval system