KEGG   PATHWAY: hgl00260
Entry
hgl00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Heterocephalus glaber (naked mole-rat)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
hgl00260  Glycine, serine and threonine metabolism
hgl00260

Module
hgl_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:hgl00260]
hgl_M00047  Creatine pathway [PATH:hgl00260]
hgl_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:hgl00260]
hgl_M00555  Betaine biosynthesis, choline => betaine [PATH:hgl00260]
hgl_M00621  Glycine cleavage system [PATH:hgl00260]
hgl_M00974  Betaine metabolism, animals, betaine => glycine [PATH:hgl00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
101703542  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
101721429  Shmt2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
101726020  Shmt1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
101709143  Agxt; alanine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
101701531  Grhpr; glyoxylate and hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
101705421  Glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
101725467  Pgam1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
101723534  Pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
101704135  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
101714576  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
101706859  Bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
101712402  Phgdh; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
101718076  Psat1; phosphoserine aminotransferase 1 [KO:K00831] [EC:2.6.1.52]
101703536  Psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
101716933  Gcat; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
101705643  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
101701151  Alas1; 5'-aminolevulinate synthase 1 [KO:K00643] [EC:2.3.1.37]
101699592  Alas2; 5'-aminolevulinate synthase 2 [KO:K00643] [EC:2.3.1.37]
101725537  Maoa; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
101724899  Maob; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
101709673  Aoc3; membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
101721663  membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
101725465  Gldc; glycine decarboxylase [KO:K00281] [EC:1.4.4.2]
101711434  Amt; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
101699518  Dld; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
101724619  Gcsh; glycine cleavage system protein H [KO:K02437]
101720613  glycine cleavage system H protein, mitochondrial [KO:K02437]
106009802  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
101707719  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
101715931  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
101711073  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
101715888  Dao; D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
101714498  Agxt2; alanine--glyoxylate aminotransferase 2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
101696418  Gatm; glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
101701700  Gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
101716121  Chdh; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
101711696  Aldh7a1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
101723121  Bhmt; betaine--homocysteine S-methyltransferase [KO:K00544] [EC:2.1.1.5]
101722315  Dmgdh; dimethylglycine dehydrogenase [KO:K00315] [EC:1.5.8.4]
101724480  Pipox; pipecolic acid and sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
101717296  Sardh; sarcosine dehydrogenase [KO:K00314] [EC:1.5.8.3]
101697457  Gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
101703797  Cbs; cystathionine-beta-synthase [KO:K01697] [EC:4.2.1.22]
101718068  Cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
101722640  Sds; serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
101723200  Sdsl; serine dehydratase like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
101701179  Srr; serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
hgl00010  Glycolysis / Gluconeogenesis
hgl00020  Citrate cycle (TCA cycle)
hgl00230  Purine metabolism
hgl00250  Alanine, aspartate and glutamate metabolism
hgl00270  Cysteine and methionine metabolism
hgl00290  Valine, leucine and isoleucine biosynthesis
hgl00330  Arginine and proline metabolism
hgl00470  D-Amino acid metabolism
hgl00564  Glycerophospholipid metabolism
hgl00600  Sphingolipid metabolism
hgl00620  Pyruvate metabolism
hgl00630  Glyoxylate and dicarboxylate metabolism
hgl00640  Propanoate metabolism
hgl00860  Porphyrin metabolism
hgl00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system