KEGG   PATHWAY: hsp04070
Entry
hsp04070                    Pathway                                
Name
Phosphatidylinositol signaling system - Hippoglossus stenolepis (Pacific halibut)
Class
Environmental Information Processing; Signal transduction
Pathway map
hsp04070  Phosphatidylinositol signaling system
hsp04070

Organism
Hippoglossus stenolepis (Pacific halibut) [GN:hsp]
Gene
118114972  pi4kab; phosphatidylinositol 4-kinase, catalytic, alpha b isoform X1 [KO:K00888] [EC:2.7.1.67]
118125683  pi4kaa; phosphatidylinositol 4-kinase alpha isoform X1 [KO:K00888] [EC:2.7.1.67]
118124461  phosphatidylinositol 4-kinase beta [KO:K19801] [EC:2.7.1.67]
118113898  pi4kb; phosphatidylinositol 4-kinase beta isoform X1 [KO:K19801] [EC:2.7.1.67]
118116994  pi4k2b; phosphatidylinositol 4-kinase type 2-beta [KO:K13711] [EC:2.7.1.67]
118118490  pi4k2a; phosphatidylinositol 4-kinase type 2-alpha [KO:K13711] [EC:2.7.1.67]
118113814  phosphatidylinositol-3-phosphatase SAC1-B [KO:K21797] [EC:3.1.3.-]
118124427  sacm1la; phosphatidylinositol-3-phosphatase SAC1-A isoform X1 [KO:K21797] [EC:3.1.3.-]
118119217  inpp5f; phosphatidylinositide phosphatase SAC2 isoform X1 [KO:K21798] [EC:3.1.3.-]
118114825  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
118118006  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
118113453  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
118124780  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
118125653  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
124854802  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
118113648  inpp5b; type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X2 [KO:K01099] [EC:3.1.3.36]
118112513  ocrl; inositol polyphosphate 5-phosphatase OCRL isoform X1 [KO:K01099] [EC:3.1.3.36]
124852403  inpp5e; phosphatidylinositol polyphosphate 5-phosphatase type IV [KO:K20278] [EC:3.1.3.36]
118121956  synj1; synaptojanin-1 isoform X1 [KO:K20279] [EC:3.1.3.36]
118106261  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118117868  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118111369  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
118121033  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118102955  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118114686  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
118117905  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118117936  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118120979  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
118125392  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118120902  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118100343  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118118921  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118120964  inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
118105914  inppl1a; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A isoform X1 [KO:K15909] [EC:3.1.3.86]
118112055  inppl1b; inositol polyphosphate phosphatase-like 1b isoform X1 [KO:K15909] [EC:3.1.3.86]
118116682  inpp4b; type II inositol 3,4-bisphosphate 4-phosphatase isoform X1 [KO:K01109] [EC:3.1.3.66]
118120509  inpp4aa; inositol polyphosphate-4-phosphatase type I A isoform X1 [KO:K01109] [EC:3.1.3.66]
118103211  LOW QUALITY PROTEIN: inositol polyphosphate-4-phosphatase type I A [KO:K01109] [EC:3.1.3.66]
118120546  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
118102543  mtm1; myotubularin [KO:K01108] [EC:3.1.3.64 3.1.3.95]
118122147  mtmr2; myotubularin-related protein 2 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
118102542  mtmr1a; myotubularin-related protein 1a isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
118114797  mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
118121946  mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
118098765  mtmr6; myotubularin-related protein 6 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
118118204  LOW QUALITY PROTEIN: myotubularin-related protein 7-like [KO:K18083] [EC:3.1.3.64 3.1.3.95]
118112577  mtmr7a; myotubularin-related protein 7a [KO:K18083] [EC:3.1.3.64 3.1.3.95]
118103314  mtmr14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
118098407  pip4k2aa; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
118116561  phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
118110777  pip4k2ca; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
118104980  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
118118156  pip4p1a; type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-A [KO:K13084] [EC:3.1.3.78]
118102936  type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-B [KO:K13084] [EC:3.1.3.78]
118124848  pip4p2; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1 [KO:K13084] [EC:3.1.3.78]
118102367  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
118109288  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
118110261  pik3c2g; phosphatidylinositol 3-kinase C2 domain-containing subunit gamma [KO:K00923] [EC:2.7.1.154]
118104829  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X3 [KO:K00923] [EC:2.7.1.154]
118099588  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
118099902  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
118102520  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
118119037  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
118116696  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
118098570  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a isoform X1 [KO:K05857] [EC:3.1.4.11]
118122935  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A isoform X1 [KO:K05857] [EC:3.1.4.11]
118100891  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
118117665  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
118119924  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
118100595  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
118121605  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
118110564  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
118109207  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
118109886  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
118100386  ipmkb; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.140 2.7.1.151]
118106370  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
118099419  itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
118116569  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
118112799  si:ch73-22a13.3; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
118121888  itpkca; inositol-trisphosphate 3-kinase C isoform X1 [KO:K00911] [EC:2.7.1.127]
118119362  inositol polyphosphate-5-phosphatase A isoform X1 [KO:K01106] [EC:3.1.3.56]
118106234  inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
118116460  itpk1b; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
118104543  ippk; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
118104131  ip6k1; LOW QUALITY PROTEIN: inositol hexakisphosphate kinase 1 [KO:K07756] [EC:2.7.4.21]
118104731  ip6k2b; inositol hexakisphosphate kinase 2b [KO:K07756] [EC:2.7.4.21]
118104871  inositol hexakisphosphate kinase 2 [KO:K07756] [EC:2.7.4.21]
118109362  ppip5k1b; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X2 [KO:K13024] [EC:2.7.4.24]
118102880  ppip5k1a; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1 [KO:K13024] [EC:2.7.4.24]
118105357  inpp1; inositol polyphosphate 1-phosphatase [KO:K01107] [EC:3.1.3.57]
118098757  inositol monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
118098759  impa2; inositol monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
118117474  inositol monophosphatase 1-like [KO:K01092] [EC:3.1.3.25]
118117475  inositol monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
118117908  bpnt2; inositol monophosphatase 3 [KO:K15759] [EC:3.1.3.7]
118105981  diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
118101292  dgki; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
118110784  dgkaa; diacylglycerol kinase, alpha a [KO:K00901] [EC:2.7.1.107]
118102730  si:dkey-172j4.3; LOW QUALITY PROTEIN: diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
118103520  diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
118112603  diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
118119850  dgkh; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
118120059  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
118105428  dgkab; diacylglycerol kinase, alpha b [KO:K00901] [EC:2.7.1.107]
118110189  dgkzb; LOW QUALITY PROTEIN: diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
118114262  dgkb; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
118120229  diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
118114946  cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
118115522  cds1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
118123500  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
118104834  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118105042  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118109898  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118111281  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
118117698  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118123848  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118121712  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118123258  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118113177  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
118106082  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
118099217  calm1b; calmodulin-1b [KO:K02183]
118115889  calm1a; calmodulin-1a [KO:K02183]
118109799  calml4b; calmodulin-like protein 4 isoform X1 [KO:K02183]
118111614  calml4a; calmodulin-like protein 4a [KO:K02183]
118118820  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
118105150  calglandulin [KO:K02183]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
hsp04020  Calcium signaling pathway
hsp04144  Endocytosis
hsp04510  Focal adhesion
KO pathway
ko04070   
LinkDB

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