KEGG   PATHWAY: mamb04070
Entry
mamb04070                   Pathway                                
Name
Phosphatidylinositol signaling system - Megalobrama amblycephala (Wuchang bream)
Class
Environmental Information Processing; Signal transduction
Pathway map
mamb04070  Phosphatidylinositol signaling system
mamb04070

Organism
Megalobrama amblycephala (Wuchang bream) [GN:mamb]
Gene
125262492  pi4kaa; LOW QUALITY PROTEIN: phosphatidylinositol 4-kinase alpha [KO:K00888] [EC:2.7.1.67]
125279551  pi4kab; phosphatidylinositol 4-kinase, catalytic, alpha b isoform X1 [KO:K00888] [EC:2.7.1.67]
125280844  pi4kb; phosphatidylinositol 4-kinase beta isoform X1 [KO:K19801] [EC:2.7.1.67]
125271763  pi4k2a; phosphatidylinositol 4-kinase type 2-alpha [KO:K13711] [EC:2.7.1.67]
125272531  pi4k2b; phosphatidylinositol 4-kinase type 2-beta [KO:K13711] [EC:2.7.1.67]
125243612  sacm1lb; phosphatidylinositol-3-phosphatase SAC1-B isoform X1 [KO:K21797] [EC:3.1.3.-]
125274749  sacm1la; phosphatidylinositol-3-phosphatase SAC1-A [KO:K21797] [EC:3.1.3.-]
125276924  inpp5f; phosphatidylinositide phosphatase SAC2 isoform X1 [KO:K21798] [EC:3.1.3.-]
125258019  pip5k1ba; LOW QUALITY PROTEIN: phosphatidylinositol-4-phosphate 5-kinase, type I, beta a [KO:K00889] [EC:2.7.1.68]
125243512  pip5k1ab; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
125279671  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
125275470  pip5k1aa; LOW QUALITY PROTEIN: phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a [KO:K00889] [EC:2.7.1.68]
125250979  pip5k1cb; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b isoform X1 [KO:K00889] [EC:2.7.1.68]
125251970  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
125243087  inpp5b; type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [KO:K01099] [EC:3.1.3.36]
125258662  ocrl; inositol polyphosphate 5-phosphatase OCRL isoform X1 [KO:K01099] [EC:3.1.3.36]
125267552  inpp5e; phosphatidylinositol polyphosphate 5-phosphatase type IV [KO:K20278] [EC:3.1.3.36]
125260667  synj1; synaptojanin-1 isoform X1 [KO:K20279] [EC:3.1.3.36]
125248809  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125256148  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125259868  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125259888  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125273996  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
125267879  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125250735  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
125250270  pik3r3a; phosphoinositide-3-kinase, regulatory subunit 3a (gamma) [KO:K02649]
125255050  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125268753  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125273909  inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
125258696  inppl1b; inositol polyphosphate phosphatase-like 1b [KO:K15909] [EC:3.1.3.86]
125248110  inppl1a; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A [KO:K15909] [EC:3.1.3.86]
125271839  inpp4b; type II inositol 3,4-bisphosphate 4-phosphatase isoform X1 [KO:K01109] [EC:3.1.3.66]
125274286  inpp4ab; inositol polyphosphate-4-phosphatase type I Ab isoform X1 [KO:K01109] [EC:3.1.3.66]
125270008  inpp4aa; inositol polyphosphate-4-phosphatase type I A isoform X1 [KO:K01109] [EC:3.1.3.66]
125270362  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
125264583  mtm1; myotubularin isoform X1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
125264585  mtmr1a; myotubularin-related protein 1a isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
125252875  mtmr1b; myotubularin-related protein 1b isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
125266598  mtmr2; myotubularin-related protein 2 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
125280672  mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
125266223  myotubularin-related protein 4 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
125266290  mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
125258038  mtmr6; myotubularin-related protein 6 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
125259463  mtmr7a; myotubularin-related protein 7a [KO:K18083] [EC:3.1.3.64 3.1.3.95]
125272540  mtmr7b; myotubularin-related protein 7b isoform X1 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
125266479  mtmr8; myotubularin-related protein 8 isoform X1 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
125278116  mtmr14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
125250728  pip4k2ab; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
125260033  pip4k2ca; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
125257187  pip4k2cb; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
125257582  pip4k2aa; LOW QUALITY PROTEIN: phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
125272771  pip4p1b; type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-B [KO:K13084] [EC:3.1.3.78]
125274829  pip4p2; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1 [KO:K13084] [EC:3.1.3.78]
125251114  pip4p1a; type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-A [KO:K13084] [EC:3.1.3.78]
125264545  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
125253803  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923] [EC:2.7.1.154]
125254006  pik3c2g; phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
125256873  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
125278656  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
125278657  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125265626  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
125269274  plcb2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
125269307  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
125269308  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125258060  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a isoform X1 [KO:K05857] [EC:3.1.4.11]
125270556  plcd4b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
125272299  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A isoform X1 [KO:K05857] [EC:3.1.4.11]
125254035  plcd4a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
125250934  plcd1b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b isoform X1 [KO:K05857] [EC:3.1.4.11]
125260938  plcd3b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A isoform X1 [KO:K05857] [EC:3.1.4.11]
125255862  plce1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
125260147  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
125253968  plcg2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
125254993  ipmkb; inositol polyphosphate multikinase isoform X1 [KO:K00915] [EC:2.7.1.140 2.7.1.151]
125277244  ipmka; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.140 2.7.1.151]
125278346  itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
125252865  itpkca; LOW QUALITY PROTEIN: inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
125253846  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
125268923  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
125276508  inositol polyphosphate-5-phosphatase A isoform X1 [KO:K01106] [EC:3.1.3.56]
125277922  itpk1a; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
125268972  itpk1b; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
125263622  ippk; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
125253099  ip6k1; inositol hexakisphosphate kinase 1 [KO:K07756] [EC:2.7.4.21]
125273436  ip6k2a; inositol hexakisphosphate kinase 2a [KO:K07756] [EC:2.7.4.21]
125273742  ip6k2b; inositol hexakisphosphate kinase 2b [KO:K07756] [EC:2.7.4.21]
125265090  ppip5k1a; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1 [KO:K13024] [EC:2.7.4.24]
125246915  ppip5k1b; LOW QUALITY PROTEIN: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 [KO:K13024] [EC:2.7.4.24]
125255889  ppip5k2; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1 [KO:K13024] [EC:2.7.4.24]
125256719  inpp1; inositol polyphosphate 1-phosphatase [KO:K01107] [EC:3.1.3.57]
125256990  inositol polyphosphate 1-phosphatase-like [KO:K01107] [EC:3.1.3.57]
125258162  impa2; inositol monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
125251288  impa1; inositol monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
125250917  bpnt2; inositol monophosphatase 3 [KO:K15759] [EC:3.1.3.7]
125258724  diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
125270478  diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
125264488  si:dkey-172j4.3; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
125244725  dgki; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
125259556  dgkaa; diacylglycerol kinase, alpha a isoform X1 [KO:K00901] [EC:2.7.1.107]
125265008  dgkza; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
125272926  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
125246794  dgkzb; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
125248143  diacylglycerol kinase delta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
125249375  dgkb; LOW QUALITY PROTEIN: diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
125256706  dgkab; diacylglycerol kinase, alpha b [KO:K00901] [EC:2.7.1.107]
125269914  dgkh; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
125266466  cds2; phosphatidate cytidylyltransferase 2 isoform X1 [KO:K00981] [EC:2.7.7.41]
125266999  cds1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
125249713  uncharacterized protein LOC125249713 [KO:K00981] [EC:2.7.7.41]
125278513  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
125273734  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
125256994  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
125254454  itpr2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
125279368  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
125274046  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
125268438  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
125271228  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125272719  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
125242974  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
125279053  calm1b; calmodulin-1b [KO:K02183]
125264806  calml4a; calmodulin-like protein 4a [KO:K02183]
125253545  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
125247787  calml4b; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
125248338  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
125255503  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
125268828  calm1a; calmodulin-1a [KO:K02183]
125277263  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
mamb04020  Calcium signaling pathway
mamb04144  Endocytosis
mamb04510  Focal adhesion
KO pathway
ko04070   
LinkDB

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