KEGG   PATHWAY: mbez04720
Entry
mbez04720                   Pathway                                
Name
Long-term potentiation - Moschus berezovskii (Chinese forest musk deer)
Description
Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippocampus induces glutamate release and activation of glutamate receptors in dendritic spines. A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kinase II (CaM KII) . Constitutively active CaM kinase II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors. Early-phase LTP (E-LTP) expression is due, in part, to this phosphorylation of the AMPA receptor. It is hypothesized that postsynaptic Ca2+ increases generated through NMDA receptors activate several signal transduction pathways including the Erk/MAP kinase and cAMP regulatory pathways. The convergence of these pathways at the level of the CREB/CRE transcriptional pathway may increase expression of a family of genes required for late-phase LTP (L-LTP).
Class
Organismal Systems; Nervous system
Pathway map
mbez04720  Long-term potentiation
mbez04720

Other DBs
GO: 0048169
Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129559020  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
129542260  GRIA2; glutamate receptor 2 [KO:K05198]
129552085  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
129560440  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129558401  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
129540637  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129536516  PPP1R1A; protein phosphatase 1 regulatory subunit 1A [KO:K08050]
129542802  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
129537845  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
129539892  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
129548700  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
129558512  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
129552563  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
129562150  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
129555700  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
129536287  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
129541434  ras-related protein Rap-1A-like [KO:K04353]
129541813  RAP1A; ras-related protein Rap-1A [KO:K04353]
129537257  RAP1B; ras-related protein Rap-1b [KO:K07836]
129556888  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129562133  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
129555711  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129539040  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
129539066  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
129545368  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
129536255  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
129538079  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
129546598  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
129535727  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129562982  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
129563274  calmodulin-1-like [KO:K02183]
129563997  calmodulin-like [KO:K02183]
129564337  calmodulin-1-like [KO:K02183]
129550549  calmodulin-1-like [KO:K02183]
129550970  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
129551800  calmodulin-1-like [KO:K02183]
129539293  CALM2; calmodulin-2 isoform X1 [KO:K02183]
129546635  CALM3; calmodulin-3 [KO:K02183]
129554732  uncharacterized protein LOC129554732 [KO:K02183]
129555444  calmodulin-like [KO:K02183]
129562351  calmodulin-1-like [KO:K02183]
129562550  CALM1; calmodulin-1 isoform X1 [KO:K02183]
129535642  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
129545322  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
129536687  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
129540547  LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
129559029  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
129548597  HRAS; GTPase HRas isoform X1 [KO:K02833]
129537164  KRAS; GTPase KRas isoform X1 [KO:K07827]
129541808  NRAS; GTPase NRas [KO:K07828]
129564326  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
129552712  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129547721  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129562372  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
129558523  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129542485  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129545501  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129564221  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
129538601  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
129561129  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
129561149  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
129535177  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
129548039  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
129536224  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
129543844  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
129544793  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
129545462  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129546400  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
129561218  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
129549079  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
129556766  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
129548814  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
129563187  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
129556526  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
129556560  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00305  Magnesium cation
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
Reference
PMID:15652868
  Authors
Blitzer RD, Iyengar R, Landau EM.
  Title
Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity.
  Journal
Biol Psychiatry 57:113-9 (2005)
DOI:10.1016/j.biopsych.2004.02.031
Reference
PMID:10652548
  Authors
Soderling TR, Derkach VA.
  Title
Postsynaptic protein phosphorylation and LTP.
  Journal
Trends Neurosci 23:75-80 (2000)
DOI:10.1016/S0166-2236(99)01490-3
Reference
PMID:11378299
  Authors
Poser S, Storm DR.
  Title
Role of Ca2+-stimulated adenylyl cyclases in LTP and memory formation.
  Journal
Int J Dev Neurosci 19:387-94 (2001)
DOI:10.1016/S0736-5748(00)00094-0
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
  Authors
Purves D, Augustine GJ (ed).
  Title
Neuroscience
  Journal
Sunderland, Mass.:Sinauer Associates (2004)
Reference
PMID:14715912
  Authors
Lynch MA.
  Title
Long-term potentiation and memory.
  Journal
Physiol Rev 84:87-136 (2004)
DOI:10.1152/physrev.00014.2003
Reference
PMID:15857686
  Authors
Kelly PT, Mackinnon RL 2nd, Dietz RV, Maher BJ, Wang J.
  Title
Postsynaptic IP3 receptor-mediated Ca2+ release modulates synaptic transmission in hippocampal neurons.
  Journal
Brain Res Mol Brain Res 135:232-48 (2005)
DOI:10.1016/j.molbrainres.2004.12.018
Reference
PMID:9697848
  Authors
Berridge MJ.
  Title
Neuronal calcium signaling.
  Journal
Neuron 21:13-26 (1998)
DOI:10.1016/S0896-6273(00)80510-3
Related
pathway
mbez04010  MAPK signaling pathway
mbez04020  Calcium signaling pathway
mbez04724  Glutamatergic synapse
KO pathway
ko04720   
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