KEGG   PATHWAY: mbez04010
Entry
mbez04010                   Pathway                                
Name
MAPK signaling pathway - Moschus berezovskii (Chinese forest musk deer)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mbez04010  MAPK signaling pathway
mbez04010

Other DBs
GO: 0000165
Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129559399  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
129539723  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
129535727  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129547932  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
129551056  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
129564275  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
129544256  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
129545215  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
129535899  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
129551192  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
129552334  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
129547871  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
129547938  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
129536148  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
129544343  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
129558402  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
129536036  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
129538305  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
129544794  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
129536884  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
129545111  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
129538179  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
129538172  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
129546398  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
129546399  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
129546162  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
129558401  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
129540637  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129544793  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
129545462  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129546400  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
129545783  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
129558470  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
129556888  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129562133  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
129555711  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129539040  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
129550347  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
129557989  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
129563041  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
129548806  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
129539227  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
129546863  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
129542549  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
129540445  NF1; neurofibromin isoform X1 [KO:K08052]
129558112  RASA1; ras GTPase-activating protein 1 [KO:K04352]
129547049  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
129541434  ras-related protein Rap-1A-like [KO:K04353]
129541813  RAP1A; ras-related protein Rap-1A [KO:K04353]
129537257  RAP1B; ras-related protein Rap-1b [KO:K07836]
129561712  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
129539010  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
129561639  EREG; proepiregulin [KO:K09784]
129562045  AREG; amphiregulin [KO:K09782]
129559536  FGF1; fibroblast growth factor 1 [KO:K18496]
129542296  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
129555960  FGF8; fibroblast growth factor 8 [KO:K04358]
129556389  FGF9; fibroblast growth factor 9 [KO:K04358]
129549223  FGF20; fibroblast growth factor 20 [KO:K04358]
129557346  FGF17; fibroblast growth factor 17 [KO:K04358]
129537016  FGF6; fibroblast growth factor 6 isoform X1 [KO:K04358]
129559049  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
129553142  FGF18; fibroblast growth factor 18 [KO:K04358]
129553277  FGF10; fibroblast growth factor 10 [KO:K04358]
129562082  FGF5; fibroblast growth factor 5 [KO:K04358]
129562501  FGF7; fibroblast growth factor 7 [KO:K04358]
129534906  FGF16; fibroblast growth factor 16 [KO:K04358]
129548662  FGF3; fibroblast growth factor 3 [KO:K04358]
129548663  FGF4; fibroblast growth factor 4 [KO:K04358]
129548328  FGF19; fibroblast growth factor 19 [KO:K22603]
129546182  FGF21; fibroblast growth factor 21 [KO:K22429]
129536537  FGF23; fibroblast growth factor 23 [KO:K22428]
129541318  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
129554712  BDNF; brain-derived neurotrophic factor [KO:K04355]
129536400  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
129546565  NTF4; neurotrophin-4 [KO:K12457]
129548407  INS; insulin [KO:K04526]
129535856  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
129548638  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
129545815  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
129536369  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
129542873  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
129554238  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
129541681  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
129535752  KITLG; kit ligand isoform X1 [KO:K05461]
129546548  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
129548822  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
129563157  PGF; placenta growth factor isoform X1 [KO:K16859]
129549287  VEGFC; vascular endothelial growth factor C [KO:K05449]
129564310  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
129552336  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
129559853  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
129549280  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
129561848  ANGPT4; angiopoietin-4 [KO:K05467]
129558723  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
129559061  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
129540424  EFNA4; ephrin-A4 [KO:K05462]
129540960  EFNA3; ephrin-A3 [KO:K05462]
129541056  EFNA1; ephrin-A1 [KO:K05462]
129553310  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
129559221  NRTN; neurturin [KO:K25414]
129540731  ARTN; artemin isoform X1 [KO:K25415]
129559238  PSPN; persephin [KO:K25416]
129548207  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
129544356  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
129535701  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
129538320  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
129549407  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
129555293  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
129561939  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
129559284  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
129544277  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
129540753  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
129556974  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
129558099  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
129550230  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
129562088  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
129558396  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
129559582  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
129561998  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
129556612  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
129556364  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
129559190  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
129561762  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
129552423  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
129557527  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
129537851  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
129555834  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
129544725  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
129539931  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
129562678  SOS2; son of sevenless homolog 2 [KO:K03099]
129548597  HRAS; GTPase HRas isoform X1 [KO:K02833]
129537164  KRAS; GTPase KRas isoform X1 [KO:K07827]
129541808  NRAS; GTPase NRas [KO:K07828]
129546539  RRAS; ras-related protein R-Ras [KO:K07829]
129554492  RRAS2; ras-related protein R-Ras2 [KO:K07830]
129547251  MRAS; ras-related protein M-Ras [KO:K07831]
129564326  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
129552712  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129547721  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129562372  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
129558523  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129561846  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
129542485  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129545501  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129558721  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
129540583  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
129564221  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
129538601  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
129561129  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
129561149  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
129535177  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
129536687  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
129540547  LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
129564305  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
129551756  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
129560340  MYC; myc proto-oncogene protein [KO:K04377]
129543104  SRF; serum response factor [KO:K04378]
129563123  FOS; protein c-Fos [KO:K04379]
129544523  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
129563204  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
129563217  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
129563236  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
129551278  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
129562601  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
129562711  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
129543262  TNF; tumor necrosis factor isoform X1 [KO:K03156]
129539790  IL1A; interleukin-1 alpha [KO:K04383]
129539906  IL1B; interleukin-1 beta [KO:K04519]
129546785  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
129551685  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
129562431  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
129535684  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
129539363  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
129544437  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
129556858  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
129548192  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
129551094  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129555563  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
129559352  CD14; monocyte differentiation antigen CD14 isoform X1 [KO:K04391]
129545763  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129539810  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
129554914  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
129536787  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
129544591  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
129544365  CDC42; cell division control protein 42 homolog [KO:K04393]
129547027  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
129549305  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
129539173  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
129543652  DAXX; death domain-associated protein 6 [KO:K02308]
129548144  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
129564634  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
129536594  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
129554762  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
129558359  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
129541549  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
129535825  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
129560692  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
129558603  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
129539074  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
129539792  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
129546862  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
129549029  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
129542500  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
129564068  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
129560363  STK3; serine/threonine-protein kinase 3 [KO:K04412]
129548802  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
129558685  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
129553244  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
129548770  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
129538502  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
129544535  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
129562798  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
129546816  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
129555870  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
129536213  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
129544903  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
129538284  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
129538000  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
129560696  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
129560795  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
129561294  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
129542844  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
129545508  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
129540939  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
129544045  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
129558655  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
129544242  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
129544772  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
129554787  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
129537024  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
129545232  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
129564230  FLNA; filamin-A isoform X1 [KO:K04437]
129542494  CRKL; crk-like protein [KO:K04438]
129541258  CRK; adapter molecule crk isoform X1 [KO:K04438]
129542477  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
129554677  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
129559467  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129561625  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
129555633  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129537071  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
129537073  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
129543604  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
129543888  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
129545108  mitogen-activated protein kinase 14-like [KO:K04441] [EC:2.7.11.24]
129542764  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
129551733  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
129547876  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
129563546  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
129548808  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
129560206  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
129549652  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
129546977  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
129540610  JUN; transcription factor Jun [KO:K04448]
129559160  JUND; transcription factor JunD [KO:K04449]
129537505  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
129543141  TP53; cellular tumor antigen p53 [KO:K04451]
129537221  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
129562905  MAX; protein max isoform X1 [KO:K04453]
129558183  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
129545641  HSPB1; heat shock protein beta-1 [KO:K04455]
129550706  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129551602  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129546814  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129562793  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
129536522  PTPRR; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
129549013  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
129551171  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
129553152  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
129549368  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129536461  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129539279  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129547897  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129555359  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129548624  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129536699  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
129534800  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
129551669  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
129544469  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
129546641  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
129539204  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
129543099  heat shock 70 kDa protein 1-like [KO:K03283]
129543100  heat shock 70 kDa protein 1B [KO:K03283]
129556947  heat shock cognate 71 kDa protein-like [KO:K03283]
129540977  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
129554454  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
129545711  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
129563537  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
129544202  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
129535747  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
129544511  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
129555451  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
129549430  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
129564146  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
129540576  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
129562101  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129555404  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
129548767  RELA; transcription factor p65 [KO:K04735]
129546687  RELB; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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Reference
PMID:14597384
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
PMID:22296764
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Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mbez04070  Phosphatidylinositol signaling system
mbez04110  Cell cycle
mbez04115  p53 signaling pathway
mbez04210  Apoptosis
mbez04310  Wnt signaling pathway
mbez04668  TNF signaling pathway
KO pathway
ko04010   
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