KEGG   PATHWAY: mcc03320
Entry
mcc03320                    Pathway                                
Name
PPAR signaling pathway - Macaca mulatta (rhesus monkey)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
mcc03320  PPAR signaling pathway
mcc03320

Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100424331  SORBS1; sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
106995978  [KO:K08754]
574124  UCP1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
574190  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
574212  ADIPOQ; adiponectin precursor [KO:K07296]
574296  CD36; platelet glycoprotein 4 [KO:K06259]
613250  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
693610  PLIN4; perilipin-4 isoform X3 [KO:K20254]
693740  PLIN5; perilipin-5 isoform X2 [KO:K20255]
694079  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
694739  ME1; NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
694807  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
694871  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
695439  FABP6; gastrotropin [KO:K08755]
696207  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1 [KO:K01596] [EC:4.1.1.32]
696404  ACSL5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
696484  APOA5; apolipoprotein A-V [KO:K09025]
696635  GK2; glycerol kinase 2 [KO:K00864] [EC:2.7.1.30]
696726  APOC3; apolipoprotein C-III [KO:K08759]
696743  ACAA1; 3-ketoacyl-CoA thiolase, peroxisomal isoform X1 [KO:K07513] [EC:2.3.1.16]
696969  APOA1; apolipoprotein A-I [KO:K08757]
697523  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
698127  CYP7A1; cholesterol 7-alpha-monooxygenase [KO:K00489] [EC:1.14.14.23]
698652  DBI; acyl-CoA-binding protein isoform X1 [KO:K08762]
698717  ACSBG2; long-chain-fatty-acid--CoA ligase ACSBG2 isoform X2 [KO:K15013] [EC:6.2.1.3]
699776  FABP1; fatty acid-binding protein, liver [KO:K08750]
700192  CYP27A1; sterol 26-hydroxylase, mitochondrial [KO:K00488] [EC:1.14.15.15]
701009  FABP5; fatty acid-binding protein, epidermal [KO:K08754]
701193  EHHADH; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
701365  FABP4; fatty acid-binding protein, adipocyte [KO:K08753]
701565  ACOX2; peroxisomal acyl-coenzyme A oxidase 2 isoform X2 [KO:K10214] [EC:1.17.99.3]
702553  HMGCS1; hydroxymethylglutaryl-CoA synthase, cytoplasmic [KO:K01641] [EC:2.3.3.10]
702836  AQP7; aquaporin-7 isoform X4 [KO:K08771]
703653  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
704422  ME3; NADP-dependent malic enzyme, mitochondrial isoform X1 [KO:K00029] [EC:1.1.1.40]
704908  ACSL4; long-chain-fatty-acid--CoA ligase 4 [KO:K01897] [EC:6.2.1.3]
705001  [KO:K00864] [EC:2.7.1.30]
705005  SLC27A6; long-chain fatty acid transport protein 6 isoform X1 [KO:K08749]
705168  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00249] [EC:1.3.8.7]
705197  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
705475  FABP2; fatty acid-binding protein, intestinal [KO:K08751]
706050  ACSL3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
706465  PLIN1; perilipin-1 isoform X1 [KO:K08768]
706847  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
707531  GK; glycerol kinase isoform X1 [KO:K00864] [EC:2.7.1.30]
708711  PLTP; phospholipid transfer protein isoform X1 [KO:K08761]
709676  ACSBG1; long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1 [KO:K15013] [EC:6.2.1.3]
709837  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
709944  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
710155  SCD; acyl-CoA desaturase isoform X1 [KO:K00507] [EC:1.14.19.1]
711485  ACADL; long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X3 [KO:K00255] [EC:1.3.8.8]
711693  ANGPTL4; angiopoietin-related protein 4 isoform X2 [KO:K08767]
712661  [KO:K17284]
712887  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
712934  UBC; LOW QUALITY PROTEIN: polyubiquitin-C [KO:K08770]
713541  HMGCS2; hydroxymethylglutaryl-CoA synthase, mitochondrial [KO:K01641] [EC:2.3.3.10]
713679  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
713713  SLC27A5; bile acyl-CoA synthetase [KO:K08748] [EC:6.2.1.7]
713762  FABP7; fatty acid-binding protein, brain [KO:K08756]
714150  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
714922  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
715237  SLC27A2; very long-chain acyl-CoA synthetase [KO:K08746] [EC:6.2.1.- 6.2.1.3]
715765  SCP2; non-specific lipid-transfer protein isoform X1 [KO:K08764] [EC:2.3.1.176]
717237  FABP3; fatty acid-binding protein, heart [KO:K08752]
717247  [KO:K07431] [EC:1.14.14.139]
717368  RXRB; retinoic acid receptor RXR-beta isoform X2 [KO:K08525]
717596  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
718861  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
719037  FADS2; fatty acid desaturase 2 [KO:K10226] [EC:1.14.19.3]
719140  SLC27A1; long-chain fatty acid transport protein 1 isoform X1 [KO:K08745] [EC:6.2.1.-]
719429  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X2 [KO:K19524] [EC:2.3.1.21]
719946  APOA2; apolipoprotein A-II [KO:K08758]
720697  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
721152  [KO:K08762]
722068  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
722620  SLC27A4; long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-]
722634  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
mcc00071  Fatty acid degradation
mcc00120  Primary bile acid biosynthesis
mcc00564  Glycerophospholipid metabolism
mcc04920  Adipocytokine signaling pathway
KO pathway
ko03320   

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