KEGG PATHWAY: mcep00260

PATHWAY: mcep00260

Entry

mcep00260                   Pathway

Name

Glycine, serine and threonine metabolism - Mugil cephalus (flathead mullet)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

mcep00260

Glycine, serine and threonine metabolism

Module

mcep_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:mcep00260]

mcep_M00047

Creatine pathway [PATH:mcep00260]

mcep_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mcep00260]

mcep_M00555

Betaine biosynthesis, choline => betaine [PATH:mcep00260]

mcep_M00621

Glycine cleavage system [PATH:mcep00260]

mcep_M00974

Betaine metabolism, animals, betaine => glycine [PATH:mcep00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Mugil cephalus (flathead mullet) [GN:mcep]

Gene

124996355

[KO:K00827] [EC:2.6.1.44 2.6.1.40]

124996489

[KO:K00274] [EC:1.4.3.4]

124996590

[KO:K00827] [EC:2.6.1.44 2.6.1.40]

124996692

sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

124996948

bhmT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

124997064

dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]

124997083

pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]

124997698

[KO:K00276] [EC:1.4.3.21]

124997699

[KO:K00276] [EC:1.4.3.21]

124998185

shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]

124998386

gcaT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

124998884

[KO:K00600] [EC:2.1.2.1]

124998920

amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

124998995

chdH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

124999114

tdh; L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]

125001270

[KO:K01697] [EC:4.2.1.22]

125004424

pgam1b; phosphoglycerate mutase 1b [KO:K01834] [EC:5.4.2.11]

125004563

grhprb; glyoxylate reductase/hydroxypyruvate reductase B [KO:K00049] [EC:1.1.1.79 1.1.1.81]

125005354

gcshb; glycine cleavage system protein H (aminomethyl carrier), B [KO:K02437]

125005677

gatM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

125006398

glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]

125006803

shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]

125007156

alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]

125008630

grhpra; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

125008814

agxta; alanine--glyoxylate and serine--pyruvate aminotransferase A [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

125008990

aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

125009426

[KO:K01758] [EC:4.4.1.1]

125010011

gamT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

125010498

zgc:162816; D-threo-3-hydroxyaspartate dehydratase [KO:K20498] [EC:4.3.1.18]

125010566

agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase B [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

125011578

psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

125012174

[KO:K00273] [EC:1.4.3.3]

125012339

[KO:K17989] [EC:4.3.1.17 4.3.1.19]

125012487

[KO:K00544] [EC:2.1.1.5]

125012488

[KO:K00544] [EC:2.1.1.5]

125012755

[KO:K00544] [EC:2.1.1.5]

125012756

[KO:K00544] [EC:2.1.1.5]

125012855

gldC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

125013360

pspH; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]

125014097

pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

125014469

[KO:K02437]

125014961

dldH; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

125015235

bpgM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

125017596

mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]

125017613

alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]

125017722

cbsB; cystathionine beta-synthase B [KO:K01697] [EC:4.2.1.22]

125018211

phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

125018219

[KO:K00643] [EC:2.3.1.37]

125018868

[KO:K01754] [EC:4.3.1.19]

125018892

[KO:K01834] [EC:5.4.2.11]

125022438

tha1; threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]

125023378

sdsL; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]

125023788

tdh2; L-threonine dehydrogenase 2 [KO:K15789] [EC:1.1.1.103]

125023941

gnmT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721