KEGG   PATHWAY: mcf00260
Entry
mcf00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Macaca fascicularis (crab-eating macaque)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mcf00260  Glycine, serine and threonine metabolism
mcf00260

Module
mcf_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mcf00260]
mcf_M00047  Creatine pathway [PATH:mcf00260]
mcf_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mcf00260]
mcf_M00555  Betaine biosynthesis, choline => betaine [PATH:mcf00260]
mcf_M00621  Glycine cleavage system [PATH:mcf00260]
mcf_M00974  Betaine metabolism, animals, betaine => glycine [PATH:mcf00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101865191  SRR; serine racemase isoform X2 [KO:K12235] [EC:5.1.1.18]
101865903  SHMT2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
101866609  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
101867177  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
101925100  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
101925598  BPGM; bisphosphoglycerate mutase isoform X1 [KO:K01837] [EC:5.4.2.4 5.4.2.11]
101925819  PSAT1; phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]
101926862  ALAS1; 5-aminolevulinate synthase, non-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
102115084  CBS; cystathionine beta-synthase isoform X3 [KO:K01697] [EC:4.2.1.22]
102115358  GCSH; glycine cleavage system H protein, mitochondrial isoform X2 [KO:K02437]
102117049  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
102117297  PIPOX; peroxisomal sarcosine oxidase isoform X2 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
102117863  CTH; cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
102117996  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X4 [KO:K00315] [EC:1.5.8.4]
102120326  GAMT; guanidinoacetate N-methyltransferase isoform X2 [KO:K00542] [EC:2.1.1.2]
102120771  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
102122367  SHMT1; serine hydroxymethyltransferase, cytosolic isoform X2 [KO:K00600] [EC:2.1.2.1]
102123026  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
102125836  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
102128351  PHGDH; D-3-phosphoglycerate dehydrogenase isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
102130773  [KO:K02437]
102131932  [KO:K01834] [EC:5.4.2.11]
102132786  AGXT; alanine--glyoxylate aminotransferase isoform X2 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
102133929  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
102134461  [KO:K01834] [EC:5.4.2.11]
102136126  [KO:K15789] [EC:1.1.1.103]
102138299  GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
102139165  SARDH; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]
102139171  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
102139627  SDS; L-serine dehydratase/L-threonine deaminase isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
102140074  CHDH; choline dehydrogenase, mitochondrial isoform X1 [KO:K00108] [EC:1.1.99.1]
102140240  SDSL; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
102140322  AOC3; amine oxidase [copper-containing] 3 isoform X1 [KO:K00276] [EC:1.4.3.21]
102140507  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X2 [KO:K00643] [EC:2.3.1.37]
102140666  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
102141512  AOC2; amine oxidase [copper-containing] 2 isoform X1 [KO:K00276] [EC:1.4.3.21]
102143082  AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
102144581  GRHPR; glyoxylate reductase/hydroxypyruvate reductase isoform X2 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
102146162  DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
102146667  MAOA; amine oxidase [flavin-containing] A isoform X1 [KO:K00274] [EC:1.4.3.4]
102146745  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
123572191  PSPH; phosphoserine phosphatase isoform X4 [KO:K01079] [EC:3.1.3.3]
135964338  [KO:K00276] [EC:1.4.3.21]
135970133  [KO:K01079] [EC:3.1.3.3]
141409705  [KO:K01834] [EC:5.4.2.11]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mcf00010  Glycolysis / Gluconeogenesis
mcf00020  Citrate cycle (TCA cycle)
mcf00230  Purine metabolism
mcf00250  Alanine, aspartate and glutamate metabolism
mcf00270  Cysteine and methionine metabolism
mcf00290  Valine, leucine and isoleucine biosynthesis
mcf00330  Arginine and proline metabolism
mcf00470  D-Amino acid metabolism
mcf00564  Glycerophospholipid metabolism
mcf00600  Sphingolipid metabolism
mcf00620  Pyruvate metabolism
mcf00630  Glyoxylate and dicarboxylate metabolism
mcf00640  Propanoate metabolism
mcf00860  Porphyrin metabolism
mcf00920  Sulfur metabolism
KO pathway
ko00260   

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