KEGG   PATHWAY: mcf00230
Entry
mcf00230                    Pathway                                
Name
Purine metabolism - Macaca fascicularis (crab-eating macaque)
Class
Metabolism; Nucleotide metabolism
Pathway map
mcf00230  Purine metabolism
mcf00230

Module
mcf_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mcf00230]
mcf_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mcf00230]
mcf_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mcf00230]
mcf_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mcf00230]
mcf_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mcf00230]
mcf_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mcf00230]
mcf_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:mcf00230]
Other DBs
GO: 0006163 0042278
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101864843  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
101864846  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X3 [KO:K13988] [EC:3.6.1.13]
101864855  PAICS; bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
101865103  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
101865579  RRM2B; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
101865654  [KO:K16855] [EC:3.6.1.62 3.6.1.64]
101865977  ADSS2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
101866366  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
101866457  AMPD2; AMP deaminase 2 isoform X4 [KO:K01490] [EC:3.5.4.6]
101866473  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
101866512  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
101866559  NME7; nucleoside diphosphate kinase homolog 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
101866588  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
101866782  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
101867079  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
101867090  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
101867160  AK8; adenylate kinase 8 isoform X3 [KO:K00939] [EC:2.7.4.3]
101867187  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
101867414  PRPS1; ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
101925128  GART; trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
101925390  NT5C1B; cytosolic 5'-nucleotidase 1B isoform X3 [KO:K01081] [EC:3.1.3.5]
101925611  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
101925738  ADCY10; adenylate cyclase type 10 isoform X2 [KO:K11265] [EC:4.6.1.1]
101925741  ADCY3; adenylate cyclase type 3 isoform X3 [KO:K08043] [EC:4.6.1.1]
101925770  [KO:K00940] [EC:2.7.4.6]
101925921  PGM1; phosphoglucomutase-1 isoform X4 [KO:K01835] [EC:5.4.2.2]
101926015  PDE7A; high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X2 [KO:K18436] [EC:3.1.4.53]
101926266  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
101926321  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
101926720  NT5C2; cytosolic purine 5'-nucleotidase isoform X2 [KO:K01081] [EC:3.1.3.5]
101926792  ALLC; probable inactive allantoicase isoform X1 [KO:K01477] [EC:3.5.3.4]
102114954  ADA2; adenosine deaminase 2 isoform X1 [KO:K19572] [EC:3.5.4.4]
102114976  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
102115262  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
102115606  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
102115881  APRT; adenine phosphoribosyltransferase isoform X1 [KO:K00759] [EC:2.4.2.7]
102116122  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
102116145  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1 [KO:K21138] [EC:3.1.7.2]
102116275  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
102116300  GMPR2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
102116523  NT5DC4; LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
102116995  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X2 [KO:K13755] [EC:3.1.4.17]
102117077  [KO:K00365] [EC:1.7.3.3]
102117571  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
102118162  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
102118172  FHIT; bis(5'-adenosyl)-triphosphatase isoform X3 [KO:K01522] [EC:3.6.1.29]
102118370  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
102118533  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
102118635  ENTPD5; nucleoside diphosphate phosphatase ENTPD5 isoform X3 [KO:K01511] [EC:3.6.1.6]
102118853  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
102119518  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
102120165  AK5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
102120283  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
102120329  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
102120445  [KO:K12319] [EC:4.6.1.2]
102121045  AK4; adenylate kinase 4, mitochondrial isoform X2 [KO:K00939] [EC:2.7.4.3]
102121111  HDDC2; 5'-deoxynucleotidase HDDC2 isoform X1 [KO:K07023] [EC:3.1.3.89]
102121394  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
102122152  PPAT; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
102122705  PFAS; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
102122757  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
102123837  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
102124428  PRPS1L1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
102125363  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
102125550  [KO:K00940] [EC:2.7.4.6]
102125718  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
102127299  GUCY1A2; guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
102127579  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
102129950  GUCY2F; retinal guanylyl cyclase 2 isoform X1 [KO:K12322] [EC:4.6.1.2]
102130114  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102130213  [KO:K03783] [EC:2.4.2.1]
102130472  PDE7B; 3',5'-cyclic-AMP phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
102130622  PGM2; phosphopentomutase isoform X1 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
102130702  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
102130850  GUCY2C; guanylyl cyclase C isoform X2 [KO:K12320] [EC:4.6.1.2]
102131278  RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
102131728  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102132529  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X6 [KO:K13755] [EC:3.1.4.17]
102132556  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
102132753  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
102132755  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102132860  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X3 [KO:K01510] [EC:3.6.1.5]
102132970  NT5C1A; cytosolic 5'-nucleotidase 1A isoform X1 [KO:K01081] [EC:3.1.3.5]
102133345  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X7 [KO:K01081] [EC:3.1.3.5]
102133506  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
102133707  GUK1; guanylate kinase isoform X2 [KO:K00942] [EC:2.7.4.8]
102133778  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102134008  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
102134382  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
102134704  [KO:K11265] [EC:4.6.1.1]
102134800  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
102135065  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
102135142  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
102135193  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102135923  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
102136166  [KO:K22600] [EC:4.6.1.2]
102136908  NPR2; atrial natriuretic peptide receptor 2 isoform X2 [KO:K12324] [EC:4.6.1.2]
102137434  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X3 [KO:K13757] [EC:3.1.4.35]
102137458  ADA; adenosine deaminase isoform X2 [KO:K01488] [EC:3.5.4.4]
102137521  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
102137767  PDE4D; 3',5'-cyclic-AMP phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
102138604  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
102138645  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
102138702  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
102138917  GDA; guanine deaminase isoform X2 [KO:K01487] [EC:3.5.4.3]
102139183  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
102139239  [KO:K07127] [EC:3.5.2.17]
102139399  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1 [KO:K13296] [EC:3.1.4.17]
102139503  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
102139844  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
102140422  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
102140569  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
102141108  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase isoform X2 [KO:K13485] [EC:4.1.1.97]
102141246  [KO:K16855] [EC:3.6.1.62 3.6.1.64]
102141681  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
102143137  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X2 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
102143202  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
102143449  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
102143846  LACC1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
102144582  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X2 [KO:K01518] [EC:3.6.1.17]
102144607  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type isoform X1 [KO:K01081] [EC:3.1.3.5]
102144854  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
102145152  NME4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
102145527  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
102145619  PDE4C; 3',5'-cyclic-AMP phosphodiesterase 4C isoform X2 [KO:K13293] [EC:3.1.4.53]
102146353  GUCY2D; retinal guanylyl cyclase 1 isoform X1 [KO:K12321] [EC:4.6.1.2]
102146459  PNP; purine nucleoside phosphorylase isoform X1 [KO:K03783] [EC:2.4.2.1]
102146467  PDE4B; 3',5'-cyclic-AMP phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
102146715  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
102147015  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
102147121  PDE4A; 3',5'-cyclic-AMP phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
102147209  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
102314700  AK6; adenylate kinase isoenzyme 6 isoform X1 [KO:K18532] [EC:2.7.4.3]
135967522  [KO:K00088] [EC:1.1.1.205]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mcf00030  Pentose phosphate pathway
mcf00220  Arginine biosynthesis
mcf00250  Alanine, aspartate and glutamate metabolism
mcf00260  Glycine, serine and threonine metabolism
mcf00340  Histidine metabolism
mcf00630  Glyoxylate and dicarboxylate metabolism
mcf00730  Thiamine metabolism
mcf00740  Riboflavin metabolism
mcf00790  Folate biosynthesis
KO pathway
ko00230   

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