KEGG   PATHWAY: mmu00230
Entry
mmu00230                    Pathway                                
Name
Purine metabolism - Mus musculus (house mouse)
Class
Metabolism; Nucleotide metabolism
Pathway map
mmu00230  Purine metabolism
mmu00230

Module
mmu_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mmu00230]
mmu_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mmu00230]
mmu_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mmu00230]
mmu_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mmu00230]
mmu_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mmu00230]
mmu_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mmu00230]
mmu_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:mmu00230]
Other DBs
GO: 0006163 0042278
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100862375  Entpd4b; ectonucleoside triphosphate diphosphohydrolase 4B [KO:K12305] [EC:3.6.1.6]
102216272  Ak6; adenylate kinase 6 [KO:K18532] [EC:2.7.4.3]
103850  Nt5m; 5',3'-nucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
104110  Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
104111  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
105446  Gmpr2; guanosine monophosphate reductase 2 [KO:K00364] [EC:1.7.1.7]
108147  Atic; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
109674  Ampd2; adenosine monophosphate deaminase 2 [KO:K01490] [EC:3.5.4.6]
110385  Pde4c; phosphodiesterase 4C, cAMP specific [KO:K13293] [EC:3.1.4.53]
110639  Prps2; phosphoribosyl pyrophosphate synthetase 2 [KO:K00948] [EC:2.7.6.1]
110855  Pde6c; phosphodiesterase 6C, cGMP specific, cone, alpha prime [KO:K13757] [EC:3.1.4.35]
11486  Ada; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
11512  Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
11513  Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
11514  Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
11515  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
11534  Adk; adenosine kinase [KO:K00856] [EC:2.7.1.20]
11564  Adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
11565  Adss1; adenylosuccinate synthase 1 [KO:K01939] [EC:6.3.4.4]
11566  Adss2; adenylosuccinate synthase 2 [KO:K01939] [EC:6.3.4.4]
11636  Ak1; adenylate kinase 1 [KO:K00939] [EC:2.7.4.3]
11637  Ak2; adenylate kinase 2 [KO:K00939] [EC:2.7.4.3]
11639  Ak4; adenylate kinase 4 [KO:K00939] [EC:2.7.4.3]
11717  Ampd3; adenosine monophosphate deaminase 3 [KO:K01490] [EC:3.5.4.6]
11821  Aprt; adenine phosphoribosyl transferase [KO:K00759] [EC:2.4.2.7]
12495  Entpd1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
12496  Entpd2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
12497  Entpd6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
12499  Entpd5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
13178  Dck; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
14198  Fhit; fragile histidine triad gene [KO:K01522] [EC:3.6.1.29]
14450  Gart; phosphoribosylglycinamide formyltransferase [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
14544  Gda; guanine deaminase [KO:K01487] [EC:3.5.4.3]
14917  Gucy2c; guanylate cyclase 2c [KO:K12320] [EC:4.6.1.2]
14918  Gucy2d; guanylate cyclase 2d [KO:K12321] [EC:4.6.1.2]
14919  Gucy2e; guanylate cyclase 2e [KO:K12321] [EC:4.6.1.2]
14923  Guk1; guanylate kinase 1 [KO:K00942] [EC:2.7.4.8]
15452  Hprt1; hypoxanthine phosphoribosyltransferase 1 [KO:K00760] [EC:2.4.2.8]
16434  Itpa; inosine triphosphatase (nucleoside triphosphate pyrophosphatase) [KO:K01519] [EC:3.6.1.66]
171567  Nme7; NME/NM23 family member 7 [KO:K00940] [EC:2.7.4.6]
18102  Nme1; NME/NM23 nucleoside diphosphate kinase 1 [KO:K00940] [EC:2.7.4.6]
18103  Nme2; NME/NM23 nucleoside diphosphate kinase 2 [KO:K00940] [EC:2.7.4.6]
18160  Npr1; natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
18573  Pde1a; phosphodiesterase 1A, calmodulin-dependent [KO:K13755] [EC:3.1.4.17]
18574  Pde1b; phosphodiesterase 1B, Ca2+-calmodulin dependent [KO:K13755] [EC:3.1.4.17]
18575  Pde1c; phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
18576  Pde3b; phosphodiesterase 3B, cGMP-inhibited [KO:K13296] [EC:3.1.4.17]
18577  Pde4a; phosphodiesterase 4A, cAMP specific [KO:K13293] [EC:3.1.4.53]
18578  Pde4b; phosphodiesterase 4B, cAMP specific [KO:K13293] [EC:3.1.4.53]
18582  Pde6d; phosphodiesterase 6D, cGMP-specific, rod, delta [KO:K13758]
18583  Pde7a; phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
18584  Pde8a; phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
18585  Pde9a; phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
18587  Pde6b; phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide [KO:K13756] [EC:3.1.4.35]
18588  Pde6g; phosphodiesterase 6G, cGMP-specific, rod, gamma [KO:K13759]
18605  Enpp1; ectonucleotide pyrophosphatase/phosphodiesterase 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
18950  Pnp; purine-nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
19139  Prps1; phosphoribosyl pyrophosphate synthetase 1 [KO:K00948] [EC:2.7.6.1]
20133  Rrm1; ribonucleotide reductase M1 [KO:K10807] [EC:1.17.4.1]
20135  Rrm2; ribonucleotide reductase M2 [KO:K10808] [EC:1.17.4.1]
207728  Pde2a; phosphodiesterase 2A, cGMP-stimulated [KO:K18283] [EC:3.1.4.17]
209558  Enpp3; ectonucleotide pyrophosphatase/phosphodiesterase 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
210044  Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
210808  Lacc1; laccase domain containing 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
215446  Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
218461  Pde8b; phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
22262  Uox; urate oxidase [KO:K00365] [EC:1.7.3.3]
224129  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
22436  Xdh; xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
224794  Enpp4; ectonucleotide pyrophosphatase/phosphodiesterase 4 [KO:K18424] [EC:3.6.1.29]
225600  Pde6a; phosphodiesterase 6A, cGMP-specific, rod, alpha [KO:K08718] [EC:3.1.4.35]
229363  Gmps; guanine monophosphate synthetase [KO:K01951] [EC:6.3.5.2]
229589  Prune1; prune exopolyphosphatase [KO:K01514] [EC:3.6.1.11]
229665  Ampd1; adenosine monophosphate deaminase 1 [KO:K01490] [EC:3.5.4.6]
229949  Ak5; adenylate kinase 5 [KO:K00939] [EC:2.7.4.3]
230103  Npr2; natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
230718  Nt5c1a; 5'-nucleotidase, cytosolic IA [KO:K01081] [EC:3.1.3.5]
231327  Ppat; phosphoribosyl pyrophosphate amidotransferase [KO:K00764] [EC:2.4.2.14]
231903  Urad; ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5) decarboxylase [KO:K13485] [EC:4.1.1.97]
234889  Gucy1a2; guanylate cyclase 1, soluble, alpha 2 [KO:K12318] [EC:4.6.1.2]
237823  Pfas; phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) [KO:K01952] [EC:6.3.5.3]
238871  Pde4d; phosphodiesterase 4D, cAMP specific [KO:K13293] [EC:3.1.4.53]
239134  Gucy1b2; guanylate cyclase 1, soluble, beta 2 [KO:K12319] [EC:4.6.1.2]
23917  Impdh1; inosine monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
23918  Impdh2; inosine monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
23959  Nt5e; 5' nucleotidase, ecto [KO:K19970] [EC:3.1.3.5]
23971  Papss1; 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
23972  Papss2; 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
23984  Pde10a; phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
241489  Pde11a; phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
242202  Pde5a; phosphodiesterase 5A, cGMP-specific [KO:K13762] [EC:3.1.4.35]
245650  Gucy2f; guanylate cyclase 2f [KO:K12322] [EC:4.6.1.2]
271639  Adcy10; adenylate cyclase 10 [KO:K11265] [EC:4.6.1.1]
27369  Dguok; deoxyguanosine kinase [KO:K00904] [EC:2.7.1.113]
29863  Pde7b; phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
328099  Prps1l3; phosphoribosyl pyrophosphate synthetase 1-like 3 [KO:K00948] [EC:2.7.6.1]
382985  Rrm2b; ribonucleotide reductase M2 B (TP53 inducible) [KO:K10808] [EC:1.17.4.1]
432530  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
50773  Nt5c; 5',3'-nucleotidase, cytosolic [KO:K01081] [EC:3.1.3.5]
53893  Nudt5; nudix hydrolase 5 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
54195  Gucy1b1; guanylate cyclase 1, soluble, beta 1 [KO:K12319] [EC:4.6.1.2]
54369  Nme6; NME/NM23 nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
54611  Pde3a; phosphodiesterase 3A, cGMP inhibited [KO:K19021] [EC:3.1.4.17]
56248  Ak3; adenylate kinase 3 [KO:K00944] [EC:2.7.4.10]
56520  Nme4; NME/NM23 nucleoside diphosphate kinase 4 [KO:K00940] [EC:2.7.4.6]
60596  Gucy1a1; guanylate cyclase 1, soluble, alpha 1 [KO:K12318] [EC:4.6.1.2]
633979  Ak9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
66355  Gmpr; guanosine monophosphate reductase [KO:K00364] [EC:1.7.1.7]
66358  Adprm; ADP-ribose/CDP-alcohol diphosphatase, manganese dependent [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
66401  Nudt2; nudix hydrolase 2 [KO:K01518] [EC:3.6.1.17]
66566  Ntpcr; nucleoside-triphosphatase, cancer-related [KO:K06928] [EC:3.6.1.15]
66681  Pgm2; phosphoglucomutase 2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
667034  Pnp2; purine-nucleoside phosphorylase 2 [KO:K03783] [EC:2.4.2.1]
66763  Nt5el; 5' nucleotidase, ecto-like [KO:K01081] [EC:3.1.3.5]
67054  Paics; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase [KO:K01587] [EC:4.1.1.21 6.3.2.6]
67464  Entpd4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
68695  Hddc3; HD domain containing 3 [KO:K21138] [EC:3.1.7.2]
68870  Ak8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
69692  Hddc2; HD domain containing 2 [KO:K07023] [EC:3.1.3.89]
70881  Nt5c1b; 5'-nucleotidase, cytosolic IB [KO:K01081] [EC:3.1.3.5]
72090  Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
72157  Pgm1; phosphoglucomutase 1 [KO:K01835] [EC:5.4.2.2]
73532  Nudt16l2; nudix hydrolase 16 like 2 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
73707  Gucy2g; guanylate cyclase 2g [KO:K22600] [EC:4.6.1.2]
74167  Nudt9; nudix hydrolase 9 [KO:K13988] [EC:3.6.1.13]
75456  Prps1l1; phosphoribosyl pyrophosphate synthetase 1-like 1 [KO:K00948] [EC:2.7.6.1]
75686  Nudt16; nudix hydrolase 16 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
76025  Cant1; calcium activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
76952  Nt5c2; 5'-nucleotidase, cytosolic II [KO:K01081] [EC:3.1.3.5]
76974  Urah; urate (5-hydroxyiso-) hydrolase [KO:K07127] [EC:3.5.2.17]
78600  Pde6h; phosphodiesterase 6H, cGMP-specific, cone, gamma [KO:K13760]
78801  Ak7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
79059  Nme3; NME/NM23 nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
94041  Allc; allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mmu00030  Pentose phosphate pathway
mmu00220  Arginine biosynthesis
mmu00250  Alanine, aspartate and glutamate metabolism
mmu00260  Glycine, serine and threonine metabolism
mmu00340  Histidine metabolism
mmu00630  Glyoxylate and dicarboxylate metabolism
mmu00730  Thiamine metabolism
mmu00740  Riboflavin metabolism
mmu00790  Folate biosynthesis
KO pathway
ko00230   

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