KEGG   PATHWAY: mpah04142
Entry
mpah04142                   Pathway                                
Name
Lysosome - Mus pahari (shrew mouse)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
mpah04142  Lysosome
mpah04142

Other DBs
GO: 0005764
Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110312865  Ap1s1; AP-1 complex subunit sigma-1A [KO:K12394]
110312962  Abcb9; ATP-binding cassette sub-family B member 9 isoform X1 [KO:K05656]
110313377  Atp6ap1; V-type proton ATPase subunit S1 isoform X1 [KO:K03662]
110313383  Ap1s2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
110313478  Smpd1; sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
110313539  Lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
110313589  Gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
110313631  Ids; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
110315092  [KO:K01365] [EC:3.4.22.15]
110315964  Atp6v0a4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
110316334  Sumf1; sulfatase-modifying factor 1 [KO:K13444] [EC:1.8.3.7]
110316441  M6pr; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
110317111  [KO:K01197] [EC:3.2.1.35]
110317225  [KO:K01197] [EC:3.2.1.35]
110317269  [KO:K01197] [EC:3.2.1.35]
110317392  [KO:K01197] [EC:3.2.1.35]
110317595  Abca2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
110317842  Ctsa; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
110317861  Ctsw; cathepsin W [KO:K08569] [EC:3.4.22.-]
110318121  Tcirg1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
110318564  Ap4e1; AP-4 complex subunit epsilon-1 [KO:K12400]
110318622  Ctsz; cathepsin Z [KO:K08568] [EC:3.4.18.1]
110319059  Tpp1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
110319147  Ap3b2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
110319598  Acp2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
110319915  Ap4b1; AP-4 complex subunit beta-1 [KO:K12401]
110319949  Mfsd8; major facilitator superfamily domain-containing protein 8 [KO:K12307]
110320301  Ctsk; cathepsin K [KO:K01371] [EC:3.4.22.38]
110320359  Manba; beta-mannosidase [KO:K01192] [EC:3.2.1.25]
110320470  Ctss; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
110320532  Dnase2b; deoxyribonuclease-2-beta [KO:K01158] [EC:3.1.22.1]
110320632  [KO:K12399]
110320655  Ctso; cathepsin O [KO:K01374] [EC:3.4.22.42]
110320827  Gba; glucosylceramidase [KO:K01201] [EC:3.2.1.45]
110320859  Sort1; sortilin [KO:K12388]
110321712  Slc11a1; natural resistance-associated macrophage protein 1 [KO:K12347]
110322114  Ctse; cathepsin E [KO:K01382] [EC:3.4.23.34]
110322425  Ap1s3; AP-1 complex subunit sigma-3 [KO:K12395]
110322779  Ppt1; palmitoyl-protein thioesterase 1 isoform X1 [KO:K01074] [EC:3.1.2.22]
110323004  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
110323162  Fuca1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
110323197  Laptm5; lysosomal-associated transmembrane protein 5 [KO:K12387]
110324398  Laptm4a; lysosomal-associated transmembrane protein 4A [KO:K12387]
110324405  Galc; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
110324412  Npc2; epididymal secretory protein E1 [KO:K13443]
110324510  Lgmn; legumain [KO:K01369] [EC:3.4.22.34]
110324745  Ap4s1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
110325109  Entpd4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
110325177  Ctsb; cathepsin B [KO:K01363] [EC:3.4.22.1]
110325224  Ap1g2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
110325244  Ap3m1; AP-3 complex subunit mu-1 isoform X1 [KO:K12398]
110325287  Ctsf; cathepsin F [KO:K01373] [EC:3.4.22.41]
110325404  [KO:K01319] [EC:3.4.21.20]
110325480  Cln5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
110325566  Cln3; battenin isoform X1 [KO:K12389]
110325909  Gga2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
110326216  Psap; prosaposin isoform X1 [KO:K12382]
110326246  Ap3d1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
110326356  Cd164; sialomucin core protein 24 [KO:K06546]
110326364  Gnptab; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
110326509  Cd63; CD63 antigen [KO:K06497]
110326715  Lipa; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
110326827  Ctsc; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
110327096  Gns; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
110327190  Dmxl2; dmX-like protein 2 isoform X1 [KO:K24155]
110327367  Glb1; beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
110327584  Hyal1; hyaluronidase-1 isoform X1 [KO:K01197] [EC:3.2.1.35]
110327585  Hyal3; hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
110327670  Ap1m2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
110327739  Hexa; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
110327750  Hyal2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
110327865  Ctsh; pro-cathepsin H isoform X1 [KO:K01366] [EC:3.4.22.16]
110328150  Slc17a5; sialin isoform X1 [KO:K12301]
110328235  Acp5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
110328763  Hexb; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
110328807  Ap3b1; AP-3 complex subunit beta-1 [KO:K12397]
110328948  Arsb; arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
110329082  [KO:K12399]
110329313  [KO:K19363]
110329675  Litaf; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
110329742  Nagpa; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
110329944  [KO:K12399]
110330131  Lamp3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
110330210  Ap1b1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
110330387  Scarb2; lysosome membrane protein 2 isoform X1 [KO:K12384]
110330411  Ctsd; cathepsin D isoform X1 [KO:K01379] [EC:3.4.23.5]
110330435  Napsa; napsin-A [KO:K08565] [EC:3.4.23.-]
110330547  Psapl1; proactivator polypeptide-like 1 [KO:K12382]
110330560  Idua; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
110331498  Gga3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
110331633  Gaa; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
110331768  Naglu; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
110331789  Ctns; cystinosin isoform X1 [KO:K12386]
110332091  Cltc; clathrin heavy chain 1 isoform X1 [KO:K04646]
110332247  Atp6v0a1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
110332332  Gm2a; ganglioside GM2 activator [KO:K12383]
110332344  Sgsh; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
110332398  Arsg; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
110332436  Cd68; macrosialin [KO:K06501]
110332857  Dmxl1; dmX-like protein 1 [KO:K24155]
110333039  Ap3s1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
110333442  Npc1; Niemann-Pick C1 protein [KO:K12385]
110333543  Wdr7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
110333669  [KO:K01365] [EC:3.4.22.15]
110333789  Cltb; clathrin light chain B isoform X1 [KO:K04645]
110333875  [KO:K09600] [EC:3.4.22.-]
110333923  [KO:K01365] [EC:3.4.22.15]
110333924  [KO:K01365] [EC:3.4.22.15]
110333975  [KO:K01365] [EC:3.4.22.15]
110334460  Gga1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
110334498  Slc11a2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
110334716  Laptm4b; lysosomal-associated transmembrane protein 4B [KO:K12387]
110334811  Arsa; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
110334850  Naga; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
110335365  Ppt2; lysosomal thioesterase PPT2 [KO:K01074] [EC:3.1.2.22]
110335722  Neu1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
110336189  Lamp1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
110336343  Ap1m1; AP-1 complex subunit mu-1 isoform X1 [KO:K12393]
110336346  Asah1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
110336493  Ap3m2; AP-3 complex subunit mu-2 [KO:K12398]
110336556  Hgsnat; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
110336805  Aga; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1 [KO:K01444] [EC:3.5.1.26]
110336924  Mcoln1; mucolipin-1 [KO:K04992]
110337216  Dnase2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
110337384  Pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
110337411  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
110337426  Man2b1; lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
110337430  Galns; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
110337593  Tldc1; TLD domain-containing protein 1 [KO:K27947]
110337746  Ap1g1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
110337908  Ncoa7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
110338063  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
110338077  Gnptg; N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X1 [KO:K10087]
110338103  Igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
110338194  Fuca2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
110338621  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
110338632  Clta; clathrin light chain A isoform X1 [KO:K04644]
110338819  Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146]
110339027  Atp6v0a2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
110339056  Gusb; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
110339123  Ap4m1; AP-4 complex subunit mu-1 isoform X1 [KO:K12402]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 22:339-352 (2022)
DOI:10.1038/s41577-021-00626-8
Related
pathway
mpah00511  Other glycan degradation
mpah00531  Glycosaminoglycan degradation
mpah04130  SNARE interactions in vesicular transport
mpah04140  Autophagy - animal
mpah04144  Endocytosis
KO pathway
ko04142   

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