KEGG   PATHWAY: mpah04140
Entry
mpah04140                   Pathway                                
Name
Autophagy - animal - Mus pahari (shrew mouse)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
mpah04140  Autophagy - animal
mpah04140

Other DBs
GO: 0006914
Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110312812  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110312858  Vps33a; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
110313487  Atg4a; cysteine protease ATG4A [KO:K08342] [EC:3.4.22.-]
110313521  Rragb; ras-related GTP-binding protein B isoform X1 [KO:K16185]
110313539  Lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
110313569  Wdr45; WD repeat domain phosphoinositide-interacting protein 4 isoform X1 [KO:K22991]
110313591  Igbp1; immunoglobulin-binding protein 1 [KO:K17606]
110313910  [KO:K10802]
110313986  Irs4; insulin receptor substrate 4 [KO:K17446]
110314623  Mtmr14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
110314671  Rab39b; ras-related protein Rab-39B [KO:K07925]
110314893  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110315092  [KO:K01365] [EC:3.4.22.15]
110315128  Rab7a; ras-related protein Rab-7a [KO:K07897]
110315796  Calcoco2; LOW QUALITY PROTEIN: calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
110315992  Rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
110316031  Tax1bp1; tax1-binding protein 1 isoform X1 [KO:K21347]
110316221  Kras; GTPase KRas isoform X1 [KO:K07827]
110316298  Gabarapl1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
110316300  Rheb; GTP-binding protein Rheb [KO:K07208]
110316995  [KO:K08512]
110317027  Atg9b; autophagy-related protein 9B [KO:K17907]
110317210  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
110317242  Atg7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
110317258  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110317344  [KO:K17606]
110317486  Vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
110317516  Gorasp2; Golgi reassembly-stacking protein 2 isoform X1 [KO:K26797]
110317534  Ambra1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
110317587  Atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
110317807  Eif2ak4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
110317844  Vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
110318315  Tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
110318382  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
110318389  [KO:K02977]
110318483  [KO:K02977]
110318630  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
110318637  Tsc1; hamartin isoform X1 [KO:K07206]
110318683  Map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
110318851  Vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
110318954  Tp53inp2; tumor protein p53-inducible nuclear protein 2 [KO:K21247]
110318967  [KO:K02833]
110319567  Hras; GTPase HRas [KO:K02833]
110319750  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110319864  Supt20h; transcription factor SPT20 homolog [KO:K21245]
110320019  Sh3glb1; endophilin-B1 isoform X1 [KO:K11248]
110320020  Mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
110320340  Nras; GTPase NRas [KO:K07828]
110320581  Rab33b; ras-related protein Rab-33B [KO:K07920]
110320962  Uvrag; UV radiation resistance-associated gene protein [KO:K21249]
110320995  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110321222  Atg4b; cysteine protease ATG4B [KO:K08342] [EC:3.4.22.-]
110321239  Atg9a; autophagy-related protein 9A [KO:K17907]
110321270  Irs1; insulin receptor substrate 1 [KO:K16172]
110321591  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
110321732  Rras2; ras-related protein R-Ras2 [KO:K07830]
110321922  Cflar; CASP8 and FADD-like apoptosis regulator [KO:K04724]
110322284  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110322409  Atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
110322555  Rab7b; ras-related protein Rab-7b isoform X1 [KO:K07898]
110322831  [KO:K02927]
110322858  Rragc; ras-related GTP-binding protein C isoform X1 [KO:K16186]
110322865  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110323060  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
110323112  Rraga; ras-related GTP-binding protein A [KO:K16185]
110323225  [KO:K02927]
110323331  Atg4c; cysteine protease ATG4C [KO:K08342] [EC:3.4.22.-]
110323363  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
110323397  Stx17; syntaxin-17 [KO:K08491]
110323448  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110323979  Hif1a; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
110324091  Atg2b; autophagy-related protein 2 homolog B [KO:K17906]
110324214  Zfyve1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
110324292  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
110324386  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110324411  Akt1s1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
110324429  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
110325177  Ctsb; cathepsin B [KO:K01363] [EC:3.4.22.1]
110325448  Atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
110325466  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110326026  Prkcd; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
110326206  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
110326250  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110326255  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
110326321  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110326410  [KO:K04526]
110326479  Dapk3; death-associated protein kinase 3 isoform X1 [KO:K08803] [EC:2.7.11.1]
110326534  Atg5; autophagy protein 5 isoform X1 [KO:K08339]
110326660  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
110326783  Nrbf2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
110327226  Vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
110327229  Atg4d; cysteine protease ATG4D [KO:K08342] [EC:3.4.22.-]
110327244  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110327251  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110327401  Mras; ras-related protein M-Ras [KO:K07831]
110327680  Pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
110327764  Atg16l2; autophagy-related protein 16-2 isoform X1 [KO:K20868]
110327965  Dapk2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
110328015  Gorasp1; Golgi reassembly-stacking protein 1 isoform X1 [KO:K26797]
110328299  [KO:K02927]
110328784  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
110328811  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110329059  Wdr41; WD repeat-containing protein 41 [KO:K23610]
110329169  Atg10; ubiquitin-like-conjugating enzyme ATG10 [KO:K17888]
110329343  Mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110329400  Rras; ras-related protein R-Ras [KO:K07829]
110329536  Snap29; synaptosomal-associated protein 29 isoform X1 [KO:K08509]
110329543  Atg3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
110329570  Rubcn; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330]
110330064  Atg2a; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
110330207  Rab1a; ras-related protein Rab-1A isoform X1 [KO:K07874]
110330336  Bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
110330351  Wdfy3; WD repeat and FYVE domain-containing protein 3 [KO:K22262]
110330391  Mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
110330411  Ctsd; cathepsin D isoform X1 [KO:K01379] [EC:3.4.23.5]
110330449  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110330503  Ykt6; synaptobrevin homolog YKT6 [KO:K08516]
110330576  Rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
110331121  Becn1; beclin-1 isoform X1 [KO:K08334]
110331200  Mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
110331327  Ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
110331346  Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
110331353  Nbr1; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
110331419  Vmp1; vacuole membrane protein 1 isoform X1 [KO:K21248]
110331422  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
110331448  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
110331504  Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
110331531  [KO:K02927]
110331543  Smcr8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
110331591  Wipi1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
110331598  Sqstm1; sequestosome-1 isoform X1 [KO:K14381]
110331608  Gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
110331651  [KO:K02927]
110331771  Plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
110331900  Wdr45b; WD repeat domain phosphoinositide-interacting protein 3 [KO:K22991]
110332652  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110332837  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
110332992  Epg5; ectopic P granules protein 5 homolog [KO:K23883]
110333306  Atg12; ubiquitin-like protein ATG12 [KO:K08336]
110333346  [KO:K02833]
110333420  [KO:K04526]
110333579  Vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
110333669  [KO:K01365] [EC:3.4.22.15]
110333780  Prkcq; protein kinase C theta type isoform X1 [KO:K18052] [EC:2.7.11.13]
110333923  [KO:K01365] [EC:3.4.22.15]
110333924  [KO:K01365] [EC:3.4.22.15]
110333975  [KO:K01365] [EC:3.4.22.15]
110334081  Optn; optineurin [KO:K19946]
110334143  Dapk1; death-associated protein kinase 1 isoform X1 [KO:K08803] [EC:2.7.11.1]
110334989  Atg101; autophagy-related protein 101 [KO:K19730]
110335033  Deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
110335497  Birc6; baculoviral IAP repeat-containing protein 6 [KO:K10586] [EC:2.3.2.23]
110336189  Lamp1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
110336304  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
110336420  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110336451  Rab8a; ras-related protein Rab-8A [KO:K07901]
110336729  Irs2; insulin receptor substrate 2 [KO:K07187]
110336738  Uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
110337220  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110337422  Gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
110337490  Map1lc3b; microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
110337886  Mlst8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
110337888  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
110338022  Stx7; syntaxin-7 [KO:K08488]
110338046  Prap1; proline-rich acidic protein 1 [KO:K21250]
110338315  Tsc2; tuberin isoform X1 [KO:K07207]
110338480  [KO:K02833]
110338656  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
110338658  Rb1cc1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
110338760  C22H9orf72; guanine nucleotide exchange C9orf72 homolog isoform X1 [KO:K23609]
110338828  Rragd; ras-related GTP-binding protein D isoform X1 [KO:K16186]
110339041  Wipi2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
110339044  Camkk2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
110339107  Ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
mpah04010  MAPK signaling pathway
mpah04141  Protein processing in endoplasmic reticulum
mpah04142  Lysosome
mpah04150  mTOR signaling pathway
mpah04152  AMPK signaling pathway
mpah04910  Insulin signaling pathway
KO pathway
ko04140   

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