KEGG   PATHWAY: msam00260
Entry
msam00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Micropterus salmoides (largemouth bass)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
msam00260  Glycine, serine and threonine metabolism
msam00260

Module
msam_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:msam00260]
msam_M00047  Creatine pathway [PATH:msam00260]
msam_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:msam00260]
msam_M00555  Betaine biosynthesis, choline => betaine [PATH:msam00260]
msam_M00621  Glycine cleavage system [PATH:msam00260]
msam_M00974  Betaine metabolism, animals, betaine => glycine [PATH:msam00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Micropterus salmoides (largemouth bass) [GN:msam]
Gene
119882389  psph; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
119883059  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
119883613  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
119885366  shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
119885826  shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
119886305  alas1; LOW QUALITY PROTEIN: 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
119886442  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
119888793  grhpra; glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
119890539  gcshb; glycine cleavage system protein H (aminomethyl carrier), b isoform X1 [KO:K02437]
119890800  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
119891819  [KO:K00273] [EC:1.4.3.3]
119891844  [KO:K00544] [EC:2.1.1.5]
119891935  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
119892370  psat1; phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]
119892499  [KO:K17989] [EC:4.3.1.17 4.3.1.19]
119893128  [KO:K02437]
119893483  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
119893559  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
119899103  grhprb; glyoxylate reductase/hydroxypyruvate reductase b [KO:K00049] [EC:1.1.1.79 1.1.1.81]
119899517  pgam1b; phosphoglycerate mutase 1b [KO:K01834] [EC:5.4.2.11]
119900510  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
119900609  [KO:K01758] [EC:4.4.1.1]
119900615  [KO:K01758] [EC:4.4.1.1]
119900653  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
119901183  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
119902066  [KO:K15789] [EC:1.1.1.103]
119902108  agxtb; LOW QUALITY PROTEIN: alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
119902465  zgc:162816; D-threo-3-hydroxyaspartate dehydratase [KO:K20498] [EC:4.3.1.18]
119903488  cbsb; cystathionine beta-synthase b [KO:K01697] [EC:4.2.1.22]
119903997  [KO:K01697] [EC:4.2.1.22]
119904085  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
119904600  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
119905566  [KO:K00643] [EC:2.3.1.37]
119905685  [KO:K00600] [EC:2.1.2.1]
119905704  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
119905716  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
119905987  alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
119909345  tdh; LOW QUALITY PROTEIN: L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]
119910108  tdh2; L-threonine dehydrogenase 2 [KO:K15789] [EC:1.1.1.103]
119910871  gnmt; glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]
119910965  sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
119914033  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
119914232  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
119914563  pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
119914706  sardh; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]
119914971  bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
119915066  si:ch211-127i16.2; probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
119916358  tha1; threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
119917301  [KO:K01834] [EC:5.4.2.11]
119917734  [KO:K01754] [EC:4.3.1.19]
119918397  aoc2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
msam00010  Glycolysis / Gluconeogenesis
msam00020  Citrate cycle (TCA cycle)
msam00230  Purine metabolism
msam00250  Alanine, aspartate and glutamate metabolism
msam00270  Cysteine and methionine metabolism
msam00290  Valine, leucine and isoleucine biosynthesis
msam00330  Arginine and proline metabolism
msam00470  D-Amino acid metabolism
msam00564  Glycerophospholipid metabolism
msam00600  Sphingolipid metabolism
msam00620  Pyruvate metabolism
msam00630  Glyoxylate and dicarboxylate metabolism
msam00640  Propanoate metabolism
msam00860  Porphyrin metabolism
msam00920  Sulfur metabolism
KO pathway
ko00260   

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