KEGG   PATHWAY: mun03320
Entry
mun03320                    Pathway                                
Name
PPAR signaling pathway - Meriones unguiculatus (Mongolian gerbil)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
mun03320  PPAR signaling pathway
mun03320

Organism
Meriones unguiculatus (Mongolian gerbil) [GN:mun]
Gene
110564451  Cd36; platelet glycoprotein 4 [KO:K06259]
110549193  Slc27a1; long-chain fatty acid transport protein 1 isoform X3 [KO:K08745] [EC:6.2.1.-]
110552453  Slc27a4; long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-]
110551944  Slc27a2; long-chain fatty acid transport protein 2 isoform X1 [KO:K08746] [EC:6.2.1.- 6.2.1.3]
110562939  Slc27a5; long-chain fatty acid transport protein 5 isoform X2 [KO:K08748] [EC:6.2.1.7]
110546922  Slc27a6; long-chain fatty acid transport protein 6 isoform X1 [KO:K08749]
110562255  Fabp1; fatty acid-binding protein, liver isoform X2 [KO:K08750]
110563855  Fabp2; fatty acid-binding protein, intestinal [KO:K08751]
110548355  Fabp3; fatty acid-binding protein, heart [KO:K08752]
110553628  Fabp4; fatty acid-binding protein, adipocyte isoform X1 [KO:K08753]
110553639  Fabp5; fatty acid-binding protein 5 isoform X1 [KO:K08754]
110555448  Fabp6; gastrotropin [KO:K08755]
110565561  Fabp7; fatty acid-binding protein, brain isoform X1 [KO:K08756]
110545043  Ppara; peroxisome proliferator-activated receptor alpha isoform X2 [KO:K07294]
110549176  Rxra; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
110543383  Rxrb; retinoic acid receptor RXR-beta isoform X2 [KO:K08525]
110551800  Rxrg; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
110543981  Ppard; peroxisome proliferator-activated receptor delta [KO:K04504]
110550822  Pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
110556392  Hmgcs1; hydroxymethylglutaryl-CoA synthase, cytoplasmic [KO:K01641] [EC:2.3.3.10]
110545910  Hmgcs2; hydroxymethylglutaryl-CoA synthase, mitochondrial [KO:K01641] [EC:2.3.3.10]
110550120  Apoa1; apolipoprotein A-I [KO:K08757]
110554450  Apoa2; apolipoprotein A-II isoform X2 [KO:K08758]
110550117  Apoc3; apolipoprotein C-III [KO:K08759]
110550108  Apoa5; apolipoprotein A-V [KO:K09025]
110549341  Pltp; phospholipid transfer protein [KO:K08761]
110550066  Me1; NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
110552598  Me3; NADP-dependent malic enzyme, mitochondrial isoform X1 [KO:K00029] [EC:1.1.1.40]
110548092  Fads2; acyl-CoA 6-desaturase [KO:K10226] [EC:1.14.19.3]
110552970  stearoyl-CoA desaturase 4-like [KO:K00507] [EC:1.14.19.1]
110552975  acyl-CoA desaturase 3 [KO:K00507] [EC:1.14.19.1]
110552976  stearoyl-CoA desaturase 2 [KO:K00507] [EC:1.14.19.1]
110553880  Scd5; LOW QUALITY PROTEIN: stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
110556028  acyl-CoA desaturase 1 [KO:K00507] [EC:1.14.19.1]
132646031  acyl-CoA desaturase 1-like [KO:K00507] [EC:1.14.19.1]
110541406  cytochrome P450 7A1 isoform X1 [KO:K00489] [EC:1.14.14.23]
110554660  7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [KO:K07431] [EC:1.14.14.139]
110550752  Nr1h3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
110566769  sterol 26-hydroxylase, mitochondrial isoform X1 [KO:K00488] [EC:1.14.15.15]
110558774  Dbi; acyl-CoA-binding protein isoform X1 [KO:K08762]
110548135  diazepam-binding inhibitor-like 5 [KO:K08762]
110541256  Lpl; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
110556811  Acsl1; long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
110549413  Acsl3; fatty acid CoA ligase Acsl3 [KO:K01897] [EC:6.2.1.3]
110561715  Acsl6; long-chain-fatty-acid--CoA ligase 6 isoform X2 [KO:K01897] [EC:6.2.1.3]
110565186  Acsl4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
110560936  Acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
110552053  Acsbg1; long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1 [KO:K15013] [EC:6.2.1.3]
110546289  long-chain-fatty-acid--CoA ligase ACSBG2-like [KO:K15013] [EC:6.2.1.3]
110546211  Acsbg2; long-chain-fatty-acid--CoA ligase ACSBG2 [KO:K15013] [EC:6.2.1.3]
110559713  Olr1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
110561900  Ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
110550763  cytochrome P450 4A11-like isoform X1 [KO:K07425] [EC:1.14.14.80]
110539795  cytochrome P450 4A14-like [KO:K07425] [EC:1.14.14.80]
110539797  cytochrome P450 4A10 isoform X1 [KO:K07425] [EC:1.14.14.80]
110541278  cytochrome P450 4A12B [KO:K07425] [EC:1.14.14.80]
110555052  3-ketoacyl-CoA thiolase B, peroxisomal [KO:K07513] [EC:2.3.1.16]
110555058  3-ketoacyl-CoA thiolase B, peroxisomal-like isoform X1 [KO:K07513] [EC:2.3.1.16]
110563883  Scp2; sterol carrier protein 2 [KO:K08764] [EC:2.3.1.176]
110548021  Acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
110559473  Acox3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
110554615  Acox2; peroxisomal acyl-coenzyme A oxidase 2 isoform X1 [KO:K10214] [EC:1.17.99.3]
110546982  Cpt1a; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
110549670  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
110546839  Cpt1c; LOW QUALITY PROTEIN: carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
110563903  Cpt2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
110560007  Acadl; long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00255] [EC:1.3.8.8]
110552859  Acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
110558111  Angptl4; angiopoietin-related protein 4 [KO:K08767]
110546303  Sorbs1; sorbin and SH3 domain-containing protein 1 isoform X5 [KO:K06086]
110562228  Plin1; perilipin-1 [KO:K08768]
110556143  Plin2; perilipin-2 [KO:K17284]
110546238  Plin5; perilipin-5 [KO:K20255]
110548131  Adipoq; adiponectin isoform X1 [KO:K07296]
110542735  interstitial collagenase A-like [KO:K01388] [EC:3.4.24.7]
110545856  Ucp1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
110559582  Ilk; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
110553013  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
110556525  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
110560872  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
110564389  Gk2; glycerol kinase 2 [KO:K00864] [EC:2.7.1.30]
110540958  Gk; glycerol kinase isoform X1 [KO:K00864] [EC:2.7.1.30]
110561995  glycerol kinase-like [KO:K00864] [EC:2.7.1.30]
110547100  Aqp7; aquaporin-7 [KO:K08771]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
mun00071  Fatty acid degradation
mun00120  Primary bile acid biosynthesis
mun00564  Glycerophospholipid metabolism
mun04920  Adipocytokine signaling pathway
KO pathway
ko03320   
LinkDB

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