KEGG   PATHWAY: ncc03013
Entry
ncc03013                    Pathway                                
Name
Nucleocytoplasmic transport - Notothenia coriiceps (black rockcod)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
ncc03013  Nucleocytoplasmic transport
ncc03013

Other DBs
GO: 0050658
Organism
Notothenia coriiceps (black rockcod) [GN:ncc]
Gene
104941779  [KO:K23940]
104942260  [KO:K14319]
104942422  thoc1; THO complex subunit 1 [KO:K12878]
104942583  aaas; aladin [KO:K14320]
104942742  [KO:K10577]
104942954  [KO:K18727]
104943102  [KO:K18723]
104943174  [KO:K14289]
104943187  [KO:K12875]
104943444  [KO:K15043]
104944001  [KO:K12877]
104944100  [KO:K12160]
104944846  upf1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
104945287  xpo6; exportin-6 [KO:K25204]
104945654  sumo1; small ubiquitin-related modifier 1 [KO:K12160]
104945821  nup37; nucleoporin Nup37 [KO:K14302]
104946064  sumo2; small ubiquitin-related modifier 2 [KO:K12160]
104946085  nup85; nuclear pore complex protein Nup85 [KO:K14304]
104946327  ube2i; SUMO-conjugating enzyme UBC9 [KO:K10577]
104946582  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
104947047  nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
104947810  thoc5; THO complex subunit 5 homolog [KO:K13174]
104947843  [KO:K23940]
104947988  [KO:K12160]
104948257  [KO:K14306]
104948528  alyref; THO complex subunit 4 [KO:K12881]
104948986  ipo5; importin-5 [KO:K20222]
104949277  [KO:K12875]
104949793  rbm8a; RNA-binding protein 8A isoform X1 [KO:K12876]
104950205  tnpo3; transportin-3 [KO:K15436]
104950499  nup205; nuclear pore complex protein Nup205 [KO:K14310]
104950926  cse1l; exportin-2 [KO:K18423]
104951659  nupl1; nucleoporin p58/p45 isoform X1 [KO:K14307]
104951738  [KO:K14310]
104951889  kpna3; importin subunit alpha-4 isoform X1 [KO:K23583]
104952204  [KO:K18752]
104952351  phax; phosphorylated adapter RNA export protein [KO:K14291]
104952685  [KO:K18727]
104952863  nupl2; nucleoporin-like protein 2 [KO:K14321]
104952985  [KO:K15043]
104953376  ran; GTP-binding nuclear protein Ran [KO:K07936]
104953711  nup93; nuclear pore complex protein Nup93 [KO:K14309]
104953851  [KO:K03231]
104953872  [KO:K03231]
104953922  ipo4; importin-4 [KO:K20221]
104954272  kpna4; importin subunit alpha-3 [KO:K23583]
104954276  nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
104954580  [KO:K03231]
104954894  ipo13; importin-13 [KO:K25202]
104954923  pnn; pinin [KO:K13114]
104955644  nup54; nucleoporin p54 [KO:K14308]
104955753  casc3; protein CASC3 [KO:K14323]
104956040  [KO:K12172] [EC:2.3.2.-]
104956261  [KO:K12881]
104956337  nxt2; NTF2-related export protein 2 [KO:K14285]
104956584  acin1; apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
104957169  tmem33; transmembrane protein 33 [KO:K20724]
104957266  wibg; partner of Y14 and mago [KO:K14294]
104957420  [KO:K23940]
104957447  nup88; nuclear pore complex protein Nup88 [KO:K14318]
104957838  [KO:K14311]
104958032  [KO:K18655] [EC:5.6.2.7]
104958147  [KO:K14326] [EC:5.6.2.5 5.6.2.3]
104958714  [KO:K12160]
104959322  nup155; nuclear pore complex protein Nup155 [KO:K14312]
104960163  rnps1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
104960295  [KO:K03231]
104960519  [KO:K14328]
104960715  srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
104960893  [KO:K18725]
104961253  [KO:K14315]
104961564  ipo9; importin-9 [KO:K20224]
104961670  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
104961694  xpo1; exportin-1 [KO:K14290]
104962089  [KO:K14313]
104962148  nup43; nucleoporin Nup43 [KO:K14305]
104962723  thoc3; THO complex subunit 3 [KO:K12880]
104962965  ipo7; importin-7 [KO:K20223]
104963117  [KO:K25201]
104964092  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
104964365  [KO:K15043]
104964974  xpo4; exportin-4 [KO:K25203]
104965903  upf3b; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
104965967  senp2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
104966757  nup210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
104967098  rae1; mRNA export factor isoform X1 [KO:K14298]
104968006  nxf1; nuclear RNA export factor 1 [KO:K14284]
104968105  tpr; nucleoprotein TPR isoform X1 [KO:K09291]
104968249  ahctf1; protein ELYS [KO:K25129]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
ncc03015  mRNA surveillance pathway
KO pathway
ko03013   

DBGET integrated database retrieval system