KEGG   PATHWAY: onl00600
Entry
onl00600                    Pathway                                
Name
Sphingolipid metabolism - Oreochromis niloticus (Nile tilapia)
Class
Metabolism; Lipid metabolism
Pathway map
onl00600  Sphingolipid metabolism
onl00600

Module
onl_M00066  Lactosylceramide biosynthesis [PATH:onl00600]
onl_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:onl00600]
onl_M00094  Ceramide biosynthesis [PATH:onl00600]
onl_M00099  Sphingosine biosynthesis [PATH:onl00600]
onl_M00100  Sphingosine degradation [PATH:onl00600]
Other DBs
GO: 0006665
Organism
Oreochromis niloticus (Nile tilapia) [GN:onl]
Gene
100689757  [KO:K12357] [EC:3.2.1.18]
100689911  psap; prosaposin isoform X2 [KO:K12382]
100690027  [KO:K12357] [EC:3.2.1.18]
100690294  neu3e; sialidase-3-like [KO:K12357] [EC:3.2.1.18]
100690304  [KO:K01080] [EC:3.1.3.4]
100691706  ugcg; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
100692648  acer2; alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
100692991  [KO:K07553] [EC:2.4.1.274]
100693121  [KO:K24621]
100693585  [KO:K23727]
100693815  neu3b; sialidase-3 isoform X1 [KO:K12357] [EC:3.2.1.18]
100694219  [KO:K22697] [EC:2.7.8.48 3.1.4.62]
100694799  [KO:K01080] [EC:3.1.3.4]
100695336  [KO:K12352] [EC:3.1.4.12]
100695512  cers5; ceramide synthase 5 [KO:K23727]
100695919  acer1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
100696128  ugt8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase isoform X1 [KO:K04628] [EC:2.4.1.47]
100696270  neu1; sialidase-1 precursor [KO:K01186] [EC:3.2.1.18]
100696774  [KO:K09905] [EC:2.4.1.274 2.4.1.-]
100697094  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
100697320  [KO:K01080] [EC:3.1.3.4]
100697709  glb1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
100698150  asah2; neutral ceramidase isoform X1 [KO:K12349] [EC:3.5.1.23]
100698377  sgms1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
100698562  [KO:K01080] [EC:3.1.3.4]
100698709  sgpp2; sphingosine-1-phosphate phosphatase 2 isoform X1 [KO:K04717] [EC:3.1.3.-]
100698730  [KO:K01134] [EC:3.1.6.8]
100699392  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
100699400  [KO:K04715] [EC:2.7.1.138]
100699750  gm2a; ganglioside GM2 activator [KO:K12383]
100699901  [KO:K01134] [EC:3.1.6.8]
100700285  cers6; ceramide synthase 6 isoform X1 [KO:K23727]
100700490  sgpp1; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
100701171  samd8; sphingomyelin synthase-related protein 1 [KO:K22697] [EC:2.7.8.48 3.1.4.62]
100701263  b4galnt1; beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X2 [KO:K00725] [EC:2.4.1.92]
100701522  sptlc1; serine palmitoyltransferase 1 isoform X1 [KO:K00654] [EC:2.3.1.50]
100701733  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
100702158  [KO:K24621]
100702609  sgpl1; sphingosine-1-phosphate lyase 1 isoform X2 [KO:K01634] [EC:4.1.2.27]
100702623  [KO:K12382]
100702731  [KO:K04715] [EC:2.7.1.138]
100703068  [KO:K00654] [EC:2.3.1.50]
100703085  asah1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
100703192  degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
100703783  cers1; ceramide synthase 1 isoform X1 [KO:K04710] [EC:2.3.1.299]
100703793  [KO:K12354] [EC:3.1.4.12]
100703942  kdsr; 3-ketodihydrosphingosine reductase isoform X1 [KO:K04708] [EC:1.1.1.102]
100704001  [KO:K12382]
100704071  [KO:K04715] [EC:2.7.1.138]
100704489  smpd3; sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
100704528  gba2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
100704591  sptlc2; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
100705425  [KO:K00725] [EC:2.4.1.92]
100705738  hexa; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
100705853  [KO:K01080] [EC:3.1.3.4]
100706045  [KO:K24621]
100706239  neu4; sialidase-4 [KO:K12357] [EC:3.2.1.18]
100706581  smpd2; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
100706600  smpd4; sphingomyelin phosphodiesterase 4 isoform X3 [KO:K12353] [EC:3.1.4.12]
100706987  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
100707042  [KO:K01019] [EC:2.8.2.11]
100707102  gba; glucosylceramidase [KO:K01201] [EC:3.2.1.45]
100707150  [KO:K01202] [EC:3.2.1.46]
100707418  [KO:K01202] [EC:3.2.1.46]
100708450  [KO:K12354] [EC:3.1.4.12]
100708451  plpp1; phospholipid phosphatase 1 isoform X2 [KO:K01080] [EC:3.1.3.4]
100708657  [KO:K04718] [EC:2.7.1.91]
100708717  hexb; beta-hexosaminidase subunit beta isoform X2 [KO:K12373] [EC:3.2.1.52]
100708784  plpp2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
100710068  [KO:K24621]
100710861  acer3; alkaline ceramidase 3 [KO:K04711] [EC:3.5.1.-]
100710960  [KO:K24622]
100711452  [KO:K24622]
100711467  gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
100711669  [KO:K04716] [EC:3.1.3.-]
100711880  degs1; sphingolipid delta(4)-desaturase DES1 isoform X1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
100712177  sptlc3; serine palmitoyltransferase 3 isoform X2 [KO:K00654] [EC:2.3.1.50]
100712484  gal3st1; galactosylceramide sulfotransferase isoform X2 [KO:K01019] [EC:2.8.2.11]
100712548  neu3a; sialidase-4-like [KO:K12357] [EC:3.2.1.18]
102080228  sgms2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
106096428  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
106098442  [KO:K12357] [EC:3.2.1.18]
109202898  [KO:K01134] [EC:3.1.6.8]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
C23072  Oxidized ceramide
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
onl00260  Glycine, serine and threonine metabolism
onl00601  Glycosphingolipid biosynthesis - lacto and neolacto series
onl00603  Glycosphingolipid biosynthesis - globo and isoglobo series
onl00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   

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