KEGG   PATHWAY: acun04150
Entry
acun04150                   Pathway                                
Name
mTOR signaling pathway - Athene cunicularia (burrowing owl)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
acun04150  mTOR signaling pathway
acun04150

Organism
Athene cunicularia (burrowing owl) [GN:acun]
Gene
113484625  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
113489680  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
113477758  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
113488041  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
113476511  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
113477626  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
113480814  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
113488370  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
113486542  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
113482982  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
113476637  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
113476027  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
113479797  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
113485705  FLCN; folliculin [KO:K09594]
113485265  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
113479534  FNIP2; folliculin-interacting protein 2 [KO:K20401]
113479974  ras-related GTP-binding protein A [KO:K16185]
113478152  RRAGD; ras-related GTP-binding protein D [KO:K16186]
113488240  RRAGC; ras-related GTP-binding protein C isoform X1 [KO:K16186]
113488406  SESN2; sestrin-2 [KO:K20394]
113486177  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
113487350  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
113476506  MIOS; GATOR complex protein MIOS [KO:K20407]
113476099  SEH1L; nucleoporin SEH1 [KO:K14299]
113485515  WDR24; GATOR complex protein WDR24 [KO:K20408]
113484306  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
113484846  SEC13; protein SEC13 homolog [KO:K14004]
113486206  DEPDC5; GATOR complex protein DEPDC5 [KO:K20404]
113484678  NPRL2; GATOR complex protein NPRL2 [KO:K20405]
113485474  NPRL3; GATOR complex protein NPRL3 [KO:K20406]
113489833  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
113476744  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
113486697  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
113487804  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
113476181  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
113487613  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
113485896  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
113485560  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
113487674  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
113485988  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
113476494  GRB10; growth factor receptor-bound protein 10 [KO:K20064]
113476836  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
113478323  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
113487586  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
113486041  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
113487303  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
113485172  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
113483416  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
113479543  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
113487063  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
113490514  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
113490001  RPS6; 40S ribosomal protein S6 [KO:K02991]
113489232  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
113482493  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
113489386  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
113479980  CAB39L; calcium-binding protein 39-like [KO:K08272]
113483526  CAB39; calcium-binding protein 39 [KO:K08272]
113482676  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
113489671  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
113486658  TSC1; hamartin isoform X1 [KO:K07206]
113485670  TSC2; tuberin isoform X1 [KO:K07207]
113476367  TBC1 domain family member 7-like [KO:K20396]
113477285  RHEB; GTP-binding protein Rheb [KO:K07208]
113481824  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
113491227  WNT2; protein Wnt-2 [KO:K00182]
113488894  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
113489202  WNT3; proto-oncogene Wnt-3 [KO:K00312]
113476678  WNT3A; protein Wnt-3a [KO:K00312]
113486790  protein Wnt-4-like [KO:K00408]
113487831  WNT4; protein Wnt-4 [KO:K00408]
113491596  WNT5B; protein Wnt-5b [KO:K00444]
113484834  WNT5A; protein Wnt-5a [KO:K00444]
113482396  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
113484979  WNT7A; protein Wnt-7a [KO:K00572]
113475861  WNT7B; protein Wnt-7b [KO:K00572]
113481529  WNT8B; protein Wnt-8b [KO:K00714]
113485446  WNT8A; protein Wnt-8a [KO:K00714]
113489203  WNT9B; protein Wnt-9b [KO:K01064]
113476677  WNT9A; protein Wnt-9a [KO:K01064]
113482131  WNT10A; protein Wnt-10a [KO:K01357]
113480098  protein Wnt-11b-like [KO:K01384]
113486194  WNT11; protein Wnt-11 [KO:K01384]
113491231  WNT16; protein Wnt-16 [KO:K01558]
113482562  FZD7; frizzled-7 [KO:K02432]
113478486  FZD3; frizzled-3 [KO:K02329]
113483252  FZD4; frizzled-4 [KO:K02354]
113482522  FZD5; frizzled-5 [KO:K02375]
113477222  FZD8; frizzled-8 [KO:K02375]
113476659  FZD6; frizzled-6 [KO:K02376]
113486304  FZD10; frizzled-10 [KO:K02842]
113487130  FZD9; frizzled-9 [KO:K02842]
113481166  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
113491157  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
113487790  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
113483491  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
113479281  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
113480530  LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
113488090  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113481160  insulin isoform X1 [KO:K04526]
113491340  IGF1; insulin-like growth factor I [KO:K05459]
113483985  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
113486738  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
113477828  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
113480382  SOS2; son of sevenless homolog 2 [KO:K03099]
113481169  HRAS; GTPase HRas [KO:K02833]
113491163  KRAS; GTPase KRas isoform X1 [KO:K07827]
113488912  NRAS; GTPase NRas [KO:K07828]
113475894  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
113484728  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113484193  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113489457  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113486052  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113478090  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
113478913  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
113479957  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
113488390  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
113483461  IRS1; insulin receptor substrate 1 [KO:K16172]
113483193  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
113489298  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
113489600  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113487938  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113483286  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113483483  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
113481870  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
113485931  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
113477826  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113490822  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113480539  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113481883  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
113486514  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
113489567  RICTOR; rapamycin-insensitive companion of mTOR [KO:K08267]
113491105  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
113481188  PRR5L; proline-rich protein 5-like [KO:K20411]
113485019  RHOA; transforming protein RhoA [KO:K04513]
113486719  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
113485934  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
113478259  SGK1; serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
acun00561  Glycerolipid metabolism
acun04010  MAPK signaling pathway
acun04140  Autophagy - animal
acun04810  Regulation of actin cytoskeleton
acun04910  Insulin signaling pathway
KO pathway
ko04150   
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