KEGG   PATHWAY: acun04810
Entry
acun04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Athene cunicularia (burrowing owl)
Class
Cellular Processes; Cell motility
Pathway map
acun04810  Regulation of actin cytoskeleton
acun04810

Other DBs
GO: 0030036
Organism
Athene cunicularia (burrowing owl) [GN:acun]
Gene
113490290  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
113487191  lysophosphatidic acid receptor 1-like [KO:K04289]
113490929  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
113479996  LPAR4; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 4 [KO:K04275]
113486812  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
113481656  CXCL12; stromal cell-derived factor 1 [KO:K10031]
113482188  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
113480877  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
113489757  F2R; proteinase-activated receptor 1 [KO:K03914]
113481160  insulin isoform X1 [KO:K04526]
113479739  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
113485315  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
113479640  FGF2; fibroblast growth factor 2 [KO:K18497]
113484022  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
113485186  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
113477989  FGF9; fibroblast growth factor 9 [KO:K04358]
113480233  FGF16; fibroblast growth factor 16 [KO:K04358]
113491459  FGF6; fibroblast growth factor 6 [KO:K04358]
113481251  FGF3; fibroblast growth factor 3 [KO:K04358]
113481677  FGF8; fibroblast growth factor 8 [KO:K04358]
113479601  FGF5; fibroblast growth factor 5 [KO:K04358]
113481250  FGF19; fibroblast growth factor 19 [KO:K22603]
113491200  FGF23; fibroblast growth factor 23 [KO:K22428]
113485656  PDGFA; LOW QUALITY PROTEIN: platelet-derived growth factor subunit A [KO:K04359]
113488033  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
113479700  PDGFC; platelet-derived growth factor C [KO:K05450]
113484247  PDGFD; platelet-derived growth factor D [KO:K05450]
113477535  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
113481500  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
113485394  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
113479434  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
113485173  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
113482082  FN1; fibronectin [KO:K05717]
113489589  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
113489778  ITGA2; integrin alpha-2 [KO:K06481]
113482505  ITGA4; integrin alpha-4 [KO:K06483]
113482064  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
113476922  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
113477582  ITGA9; integrin alpha-9 [KO:K06585]
113483820  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
113482072  ITGAV; integrin alpha-V [KO:K06487]
113476425  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
113482437  ITGB2; integrin beta-2 [KO:K06464]
113489245  ITGB3; integrin beta-3 [KO:K06493]
113486765  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
113482052  ITGB5; integrin beta-5 [KO:K06588]
113482408  ITGB6; integrin beta-6 [KO:K06589]
113476365  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
113483395  KNG1; LOW QUALITY PROTEIN: kininogen-1 [KO:K03898]
113480856  BDKRB1; B1 bradykinin receptor [KO:K03915]
113480647  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
113491545  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
113478234  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
113480825  CHRM4; muscarinic acetylcholine receptor M4 isoform X1 [KO:K04132]
113480276  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
113486471  C5; complement C5 isoform X1 [KO:K03994]
113489704  C6; complement component C6 [KO:K03995]
113489848  C7; complement component C7 [KO:K03996]
113482677  C8A; complement component C8 alpha chain [KO:K03997]
113482673  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
113486366  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
113489796  C9; complement component C9 [KO:K04000]
113485647  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
113486831  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
113482585  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
113484995  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
113484549  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
113486127  CRKL; crk-like protein [KO:K04438]
113487332  CRK; adapter molecule crk [KO:K04438]
113481723  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
113487500  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
113477828  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
113480382  SOS2; son of sevenless homolog 2 [KO:K03099]
113481169  HRAS; GTPase HRas [KO:K02833]
113491163  KRAS; GTPase KRas isoform X1 [KO:K07827]
113488912  NRAS; GTPase NRas [KO:K07828]
113481185  RRAS2; ras-related protein R-Ras2 [KO:K07830]
113482327  MRAS; ras-related protein M-Ras [KO:K07831]
113479986  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
113487938  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113483286  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113483483  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
113483193  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
113489298  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
113489600  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113486455  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
113483019  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
113477782  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
113475894  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
113484728  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113476970  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
113484193  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113489457  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113486052  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113477826  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113490822  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113480539  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113480061  RGCC; regulator of cell cycle RGCC [KO:K26108]
113488517  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
113490701  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
113485019  RHOA; transforming protein RhoA [KO:K04513]
113485871  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113490117  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
113486843  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
113487836  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
113482214  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
113483647  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
113479919  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
113478339  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
113481012  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
113487748  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
113476436  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
113477643  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
113489147  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
113482370  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
113484301  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
113476670  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
113486130  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
113478943  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
113488441  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
113488963  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
113486078  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
113490665  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
113487097  MYL10; myosin regulatory light chain 10 [KO:K12756]
113476325  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
113476326  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
113485534  MYH11; myosin-11 isoform X1 [KO:K10352]
113486845  MYH10; myosin-10 isoform X1 [KO:K10352]
113488156  MYH9; myosin-9 isoform X1 [KO:K10352]
113480195  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
113488369  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
113489462  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
113490107  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
113490878  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
113489142  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
113476848  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
113482503  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
113486061  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
113481856  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
113486970  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
113478078  ENAH; protein enabled homolog [KO:K05746]
113491197  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
113488382  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
113476269  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
113485074  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
113482076  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
113482552  ABI2; abl interactor 2 isoform X1 [KO:K05751]
113478707  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
113478064  ACTR2; actin-related protein 2 [KO:K17260]
113477058  ACTR3B; actin-related protein 3B [KO:K18584]
113482250  ACTR3; actin-related protein 3 [KO:K18584]
113485601  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
113485470  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
113482136  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
113486169  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
113482921  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
113483859  actin, cytoplasmic type 5 [KO:K05692]
113485595  ACTB; actin, cytoplasmic 1 [KO:K05692]
113477950  PFN3; LOW QUALITY PROTEIN: profilin-3 [KO:K05759]
113483406  PFN2; profilin-2 [KO:K05759]
113486282  PXN; paxillin [KO:K05760]
113478014  EZR; ezrin isoform X1 [KO:K08007]
113476034  RDX; radixin isoform X1 [KO:K05762]
113479947  MSN; moesin [KO:K05763]
113485195  TMSB4X; thymosin beta-4 [KO:K05764]
113480353  CFL2; cofilin-2 [KO:K05765]
113486037  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
113487308  SSH2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
113481644  VCL; vinculin [KO:K05700]
113483871  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
113490526  ras GTPase-activating-like protein IQGAP3 [KO:K05767]
113489569  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
113476793  SCIN; LOW QUALITY PROTEIN: adseverin [KO:K05768]
113486416  GSN; gelsolin isoform X1 [KO:K05768]
113480355  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
113489551  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
113478138  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
113483474  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
acun04010  MAPK signaling pathway
acun04510  Focal adhesion
acun04520  Adherens junction
KO pathway
ko04810   
LinkDB

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