KEGG   PATHWAY: acun04010
Entry
acun04010                   Pathway                                
Name
MAPK signaling pathway - Athene cunicularia (burrowing owl)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
acun04010  MAPK signaling pathway
acun04010

Other DBs
GO: 0000165
Organism
Athene cunicularia (burrowing owl) [GN:acun]
Gene
113486402  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
113475961  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
113484825  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
113482608  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
113486999  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
113485574  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
113491417  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
113488965  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
113487405  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
113484677  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
113484883  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
113491451  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
113476569  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
113481993  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
113486724  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
113487751  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
113485914  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
113486723  voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04869]
113482753  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
113486719  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
113485934  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
113485647  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
113482585  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
113481752  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113490863  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113479547  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
113478143  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
113483958  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
113490211  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
113480591  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
113478681  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
113479525  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
113487261  NF1; neurofibromin [KO:K08052]
113490284  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
113483517  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
113488776  RAP1A; ras-related protein Rap-1A [KO:K04353]
113487398  RAP1B; ras-related protein Rap-1b [KO:K07836]
113479739  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
113479569  EREG; proepiregulin [KO:K09784]
113479664  AREG; amphiregulin [KO:K09782]
113485315  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
113479640  FGF2; fibroblast growth factor 2 [KO:K18497]
113484022  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
113485186  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
113477989  FGF9; fibroblast growth factor 9 [KO:K04358]
113480233  FGF16; fibroblast growth factor 16 [KO:K04358]
113491459  FGF6; fibroblast growth factor 6 [KO:K04358]
113481251  FGF3; fibroblast growth factor 3 [KO:K04358]
113481677  FGF8; fibroblast growth factor 8 [KO:K04358]
113479601  FGF5; fibroblast growth factor 5 [KO:K04358]
113481250  FGF19; fibroblast growth factor 19 [KO:K22603]
113491200  FGF23; fibroblast growth factor 23 [KO:K22428]
113488901  NGF; beta-nerve growth factor [KO:K02582]
113481351  BDNF; brain-derived neurotrophic factor [KO:K04355]
113475888  NTF3; neurotrophin-3 [KO:K04356]
113481160  insulin isoform X1 [KO:K04526]
113491340  IGF1; insulin-like growth factor I [KO:K05459]
113481190  IGF2; insulin-like growth factor II [KO:K13769]
113485656  PDGFA; LOW QUALITY PROTEIN: platelet-derived growth factor subunit A [KO:K04359]
113488033  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
113479700  PDGFC; platelet-derived growth factor C [KO:K05450]
113484247  PDGFD; platelet-derived growth factor D [KO:K05450]
113489043  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
113491550  KITLG; kit ligand [KO:K05461]
113477922  VEGFA; vascular endothelial growth factor A [KO:K05448]
113485862  VEGFD; vascular endothelial growth factor D [KO:K05449]
113479244  VEGFC; vascular endothelial growth factor C [KO:K05449]
113491250  HGF; hepatocyte growth factor [KO:K05460]
113477367  ANGPT1; angiopoietin-1 [KO:K05465]
113478212  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
113489740  EFNA5; ephrin-A5 [KO:K05462]
113489893  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
113489496  NRTN; neurturin [KO:K25414]
113482700  ARTN; artemin [KO:K25415]
113477535  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
113482047  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
113481500  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
113485394  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
113489238  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
113490005  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
113483985  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
113479434  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
113485173  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
113485362  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
113479223  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
113486345  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
113479969  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
113485269  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
113485325  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
113479117  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
113491414  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
113490318  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
113483380  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
113486738  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
113477828  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
113480382  SOS2; son of sevenless homolog 2 [KO:K03099]
113481169  HRAS; GTPase HRas [KO:K02833]
113491163  KRAS; GTPase KRas isoform X1 [KO:K07827]
113488912  NRAS; GTPase NRas [KO:K07828]
113481185  RRAS2; ras-related protein R-Ras2 [KO:K07830]
113482327  MRAS; ras-related protein M-Ras [KO:K07831]
113475894  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
113484728  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113484193  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113489457  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113479797  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
113486052  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113482919  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
113478090  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
113478913  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
113479957  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
113488390  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
113491317  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
113488879  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
113476188  MYC; myc proto-oncogene protein [KO:K04377]
113478928  SRF; serum response factor isoform X1 [KO:K04378]
113480870  FOS; proto-oncogene c-Fos [KO:K04379]
113489247  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
113488221  STMN1; stathmin [KO:K04381]
113480509  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113480512  LOW QUALITY PROTEIN: cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113480746  cytosolic phospholipase A2 beta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
113480580  cytosolic phospholipase A2 epsilon-like isoform X1 [KO:K16342] [EC:3.1.1.4]
113480581  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113480582  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113480583  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113480584  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113488417  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
113480878  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
113483072  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
113488139  interleukin-1 beta-like [KO:K04519]
113478516  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
113480465  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
113480530  LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
113484904  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
113483509  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
113476683  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
113477102  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
113482298  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
113483045  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
113481795  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
113485871  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113490117  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
113486843  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
113487836  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
113484484  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
113479376  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
113486502  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
113476914  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
113475900  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
113481145  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
113490088  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
113487745  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
113478283  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
113478812  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
113479975  NRK; nik-related protein kinase [KO:K04407] [EC:2.7.11.1]
113489521  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
113482214  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
113483647  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
113487649  STK4; serine/threonine-protein kinase 4 [KO:K04411]
113476167  STK3; serine/threonine-protein kinase 3 [KO:K04412]
113476643  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
113489657  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
113482266  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
113477214  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
113489126  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
113480320  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
113478674  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
113483720  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
113482184  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
113488380  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
113478110  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
113478050  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
113477881  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
113486150  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
113487094  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
113486906  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
113485588  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
113486793  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
113480519  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
113485827  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
113486127  CRKL; crk-like protein [KO:K04438]
113487332  CRK; adapter molecule crk [KO:K04438]
113490908  beta-arrestin-1 [KO:K04439]
113485089  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113481395  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113479790  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113491236  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
113491286  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
113488967  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
113488974  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
113486113  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
113488889  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
113484830  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
113480392  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
113477100  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
113484543  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
113482645  JUN; transcription factor AP-1 [KO:K04448]
113482190  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
113490236  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
113477826  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113490822  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113480539  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113480290  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
113491124  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
113481142  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
113488993  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
113485411  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
113484908  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113480975  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113479692  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113481690  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113488261  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113489252  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
113478555  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
113489198  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
113478048  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
113488543  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
113483543  MECOM; MDS1 and EVI1 complex locus protein isoform X1 [KO:K04462] [EC:2.1.1.367]
113483913  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
113489146  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
113481883  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
113488090  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113487042  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
113479867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
113481738  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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