KEGG   PATHWAY: amex03440
Entry
amex03440                   Pathway                                
Name
Homologous recombination - Astyanax mexicanus (Mexican tetra)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
amex03440  Homologous recombination
amex03440

Other DBs
GO: 0000724
Organism
Astyanax mexicanus (Mexican tetra) [GN:amex]
Gene
103023330  ssbp1; single-stranded DNA-binding protein, mitochondrial [KO:K03111]
103041254  rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
103034489  mre11a; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
103021427  nbn; nibrin [KO:K10867]
103045062  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
103023552  breast cancer type 1 susceptibility protein homolog isoform X1 [KO:K10605] [EC:2.3.2.27]
103032898  bard1; BRCA1-associated RING domain protein 1 [KO:K10683]
103026942  rbbp8; DNA endonuclease RBBP8 isoform X2 [KO:K20773] [EC:3.1.-.-]
103037555  brip1; Fanconi anemia group J protein isoform X1 [KO:K15362] [EC:5.6.2.3]
103036620  topbp1; DNA topoisomerase 2-binding protein 1 [KO:K10728]
103027064  abraxas1; BRCA1-A complex subunit Abraxas 1 [KO:K20774]
103029269  uimc1; BRCA1-A complex subunit RAP80 isoform X1 [KO:K20775]
103047050  babam1; BRISC and BRCA1-A complex member 1 isoform X2 [KO:K20776]
103039594  babam2; BRISC and BRCA1-A complex member 2 [KO:K12173]
103031186  brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
103033135  palb2; partner and localizer of BRCA2 isoform X1 [KO:K10897]
103047230  brca2; breast cancer type 2 susceptibility protein isoform X2 [KO:K08775]
103029240  sem1; 26S proteasome complex subunit SEM1 [KO:K10881]
103043462  sycp3; synaptonemal complex protein 3 isoform X1 [KO:K19528]
103035479  synaptonemal complex protein 3-like [KO:K19528]
103028131  rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
103021798  replication protein A 32 kDa subunit isoform X1 [KO:K10739]
103025594  rpa2; replication protein A 32 kDa subunit [KO:K10739]
103029225  rpa3; replication protein A 14 kDa subunit [KO:K10740]
103041530  rad51; DNA repair protein RAD51 homolog 1 [KO:K04482]
103036894  rad52; DNA repair protein RAD52 homolog isoform X1 [KO:K10873]
103041821  rad51c; DNA repair protein RAD51 homolog 3 [KO:K10870]
103022755  rad51d; DNA repair protein RAD51 homolog 4 isoform X1 [KO:K10871]
111197658  xrcc2; DNA repair protein XRCC2 [KO:K10879]
103027311  xrcc3; DNA repair protein XRCC3 isoform X1 [KO:K10880]
103036648  rad54l; DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
103046210  rad54b; DNA repair and recombination protein RAD54B [KO:K10877] [EC:5.6.2.-]
103023852  pold1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
103044605  pold2; DNA polymerase delta subunit 2 [KO:K02328]
103045251  pold3; DNA polymerase delta subunit 3 [KO:K03504]
103021994  LOW QUALITY PROTEIN: DNA polymerase delta subunit 4 [KO:K03505]
125802913  DNA polymerase delta subunit 4-like [KO:K03505]
103043866  blm; Bloom syndrome protein homolog isoform X1 [KO:K10901] [EC:5.6.2.4]
103043516  top3b; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
103033060  top3a; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
103038970  mus81; crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
103036719  probable crossover junction endonuclease EME2 [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
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